Gene/Proteome Database (LMPD)

LMPD ID
LMP005214
Gene ID
19221
Species
Mus musculus (Mouse)
Gene Name
prostaglandin F2 receptor negative regulator
Gene Symbol
Ptgfrn
Synonyms
4833445A08Rik; AU042434; CD9P-1; FPRP; Trim45
Alternate Names
prostaglandin F2 receptor negative regulator; prostaglandin F2-alpha receptor regulatory protein; prostaglandin F2-alpha receptor-associated protein
Chromosome
3
Map Location
3|3 F3

Proteins

prostaglandin F2 receptor negative regulator precursor
Refseq ID NP_035327
Protein GI 50845420
UniProt ID Q9WV91
mRNA ID NM_011197
Length 879
RefSeq Status VALIDATED
MGRPAPRPLLLALLSLAVCRGRVVRVPAGTLVRVVGTELVIPCNVSDYDGPSEQNFDWSFSSSGSSFVELASTWEVGFPAQLYRERLQRGDILLRRTANDAVELHIKNVQPSDQGHYKCSTPSTDATVQGNYEDTVQVKVLADALVVGPSSRPPPGLSLREGEPFELRCIASTTSPLHTHLALRWELHRGPVHRSILALSHEGRFHPGPGYEQRYHSGDVRLDTVGSDAYRLSVARALSADQGSYRCVVSEWITEQGSWQEIQEKAVEVATVVIQPTALQLAVPRTVSVTEGKDLDLSCNITTDRVDDVRPEVTWYFKKTPDTSLLASHMLARLDRDSLVHSSPHVALSHVDTRSYHLLVRDVSKENSGYYLCLVALWAPGHNRSWHKVAEAMSAPSGVSVTWLEPEYQVYLNASKVPGFSDDPTELQCRVIDTKRLEAGVRLTVSWYYRMTRRNDDVVASELLAVMDGDWTLRYGERSKQRAQDGEFIFSKEHTDTFNFRIQRTTEEDRGNYYCVVSAWTRQRNNSWVKSKDVFSKPVNIFWASEDSVLVVKARQPKPFFAAGNTFEMTCKVSSKNIKSPRYSVLITAEKPVGDLSSPNETKYIISLDQDSVVKLENWTDASRVDGVVLEKVQEDEFRYRMYQTQVSDAGLYRCMVTAWSPIGGSLWREAATSLSNPIEIDFQTSGPTFNASVHSDTPSVTRGDLIKLFCIVTVEGAVLDPDDMAFDVSWFAVHSFGLDKAPVLLSSLDRKGVVTTGQRDWKSTVSLERVSVLEFLLQVHGSEDQDFGNYYCSVTPWVRSPTGSWQREAEIHSRPIFITVKMDVLNAFKYPLLIGVGLSTVIGLLSCLIGYCSSHWCCKKEVRETRRERRRLMSMEMD
sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2205 peptide sequence: MGRPAPRPLLLALLSLAVCRG mat_peptide: 22..879 product: Prostaglandin F2 receptor negative regulator experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9WV91.2) calculated_mol_wt: 96535 peptide sequence: RVVRVPAGTLVRVVGTELVIPCNVSDYDGPSEQNFDWSFSSSGSSFVELASTWEVGFPAQLYRERLQRGDILLRRTANDAVELHIKNVQPSDQGHYKCSTPSTDATVQGNYEDTVQVKVLADALVVGPSSRPPPGLSLREGEPFELRCIASTTSPLHTHLALRWELHRGPVHRSILALSHEGRFHPGPGYEQRYHSGDVRLDTVGSDAYRLSVARALSADQGSYRCVVSEWITEQGSWQEIQEKAVEVATVVIQPTALQLAVPRTVSVTEGKDLDLSCNITTDRVDDVRPEVTWYFKKTPDTSLLASHMLARLDRDSLVHSSPHVALSHVDTRSYHLLVRDVSKENSGYYLCLVALWAPGHNRSWHKVAEAMSAPSGVSVTWLEPEYQVYLNASKVPGFSDDPTELQCRVIDTKRLEAGVRLTVSWYYRMTRRNDDVVASELLAVMDGDWTLRYGERSKQRAQDGEFIFSKEHTDTFNFRIQRTTEEDRGNYYCVVSAWTRQRNNSWVKSKDVFSKPVNIFWASEDSVLVVKARQPKPFFAAGNTFEMTCKVSSKNIKSPRYSVLITAEKPVGDLSSPNETKYIISLDQDSVVKLENWTDASRVDGVVLEKVQEDEFRYRMYQTQVSDAGLYRCMVTAWSPIGGSLWREAATSLSNPIEIDFQTSGPTFNASVHSDTPSVTRGDLIKLFCIVTVEGAVLDPDDMAFDVSWFAVHSFGLDKAPVLLSSLDRKGVVTTGQRDWKSTVSLERVSVLEFLLQVHGSEDQDFGNYYCSVTPWVRSPTGSWQREAEIHSRPIFITVKMDVLNAFKYPLLIGVGLSTVIGLLSCLIGYCSSHWCCKKEVRETRRERRRLMSMEMD

Gene Information

Entrez Gene ID
19221
Gene Name
prostaglandin F2 receptor negative regulator
Gene Symbol
Ptgfrn
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0034389 IMP:MGI P lipid particle organization

Domain Information

InterPro Annotations

Accession Description
IPR013106 Immunoglobulin V-set domain
IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013783 Immunoglobulin-like fold

UniProt Annotations

Entry Information

Gene Name
prostaglandin F2 receptor negative regulator
Protein Entry
FPRP_MOUSE
UniProt ID
Q9WV91
Species
Mouse

Comments

Comment Type Description
Function Inhibits the binding of prostaglandin F2-alpha (PGF2- alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). {ECO:0000250}.
Similarity Contains 6 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Subunit Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151 (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP005214 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
50845420 RefSeq NP_035327 879 prostaglandin F2 receptor negative regulator precursor

Identical Sequences to LMP005214 proteins

Reference Database Accession Length Protein Name
GI:50845420 GenBank AAI45714.1 879 Ptgfrn protein [Mus musculus]
GI:50845420 GenBank AAI45716.1 879 Ptgfrn protein [Mus musculus]
GI:50845420 SwissProt Q9WV91.2 879 RecName: Full=Prostaglandin F2 receptor negative regulator; AltName: Full=Prostaglandin F2-alpha receptor regulatory protein; AltName: Full=Prostaglandin F2-alpha receptor-associated protein; AltName: CD_antigen=CD315; Flags: Precursor [Mus musculus]

Related Sequences to LMP005214 proteins

Reference Database Accession Length Protein Name
GI:50845420 GenBank AAC18426.1 879 prostaglandin F2a receptor regulatory protein precursor [Rattus norvegicus]
GI:50845420 GenBank AAD38383.1 879 F2 alpha prostoglandin regulatory protein [Mus musculus]
GI:50845420 GenBank EDL07630.1 872 prostaglandin F2 receptor negative regulator, partial [Mus musculus]
GI:50845420 pat US 879 Sequence 1 from patent US 5747660
GI:50845420 RefSeq NP_062116.1 879 prostaglandin F2 receptor negative regulator precursor [Rattus norvegicus]
GI:50845420 SwissProt Q62786.1 879 RecName: Full=Prostaglandin F2 receptor negative regulator; AltName: Full=Prostaglandin F2-alpha receptor regulatory protein; AltName: Full=Prostaglandin F2-alpha receptor-associated protein; AltName: CD_antigen=CD315; Flags: Precursor [Rattus norvegicus]