Gene/Proteome Database (LMPD)

LMPD ID
LMP005523
Gene ID
114799
Species
Homo sapiens (Human)
Gene Name
establishment of sister chromatid cohesion N-acetyltransferase 1
Gene Symbol
ESCO1
Synonyms
A930014I12Rik; CTF; ECO1; EFO1; ESO1
Alternate Names
N-acetyltransferase ESCO1; EFO1p; hEFO1; CTF7 homolog 1; ECO1 homolog 1; ESO1 homolog 1; establishment factor-like protein 1; establishment of cohesion 1 homolog 1
Chromosome
18
Map Location
18q11.2
EC Number
2.3.1.-
Summary
ESCO1 belongs to a conserved family of acetyltransferases involved in sister chromatid cohesion (Hou and Zou, 2005 [PubMed 15958495]).[supplied by OMIM, Mar 2008]
Orthologs
View orthologs and multiple alignments for ESCO1

Proteins

N-acetyltransferase ESCO1
Refseq ID NP_443143
Protein GI 116235478
UniProt ID Q5FWF5
mRNA ID NM_052911
Length 840
RefSeq Status VALIDATED
MMSIQEKSKENSSKVTKKSDDKNSETEIQDSQKNLAKKSGPKETIKSQAKSSSESKINQPELETRMSTRSSKAASNDKATKSINKNTVTVRGYSQESTKKKLSQKKLVHENPKANEQLNRRSQRLQQLTEVSRRSLRSREIQGQVQAVKQSLPPTKKEQCSSTQSKSNKTSQKHVKRKVLEVKSDSKEDENLVINEVINSPKGKKRKVEHQTACACSSQCTQGSEKCPQKTTRRDETKPVPVTSEVKRSKMATSVVPKKNEMKKSVHTQVNTNTTLPKSPQPSVPEQSDNELEQAGKSKRGSILQLCEEIAGEIESDNVEVKKESSQMESVKEEKPTEIKLEETSVERQILHQKETNQDVQCNRFFPSRKTKPVKCILNGINSSAKKNSNWTKIKLSKFNSVQHNKLDSQVSPKLGLLRTSFSPPALEMHHPVTQSTFLGTKLHDRNITCQQEKMKEINSEEVKINDITVEINKTTERAPENCHLANEIKPSDPPLDNQMKHSFDSASNKNFSQCLESKLENSPVENVTAASTLLSQAKIDTGENKFPGSAPQQHSILSNQTSKSSDNRETPRNHSLPKCNSHLEITIPKDLKLKEAEKTDEKQLIIDAGQKRFGAVSCNVCGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPEDPKYALKKVDEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNST

Gene Information

Entrez Gene ID
114799
Gene Name
establishment of sister chromatid cohesion N-acetyltransferase 1
Gene Symbol
ESCO1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000785 IDA:UniProtKB C chromatin
GO:0005654 TAS:Reactome C nucleoplasm
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0016746 IEA:UniProtKB-KW F transferase activity, transferring acyl groups
GO:0000278 TAS:Reactome P mitotic cell cycle
GO:0034421 IMP:UniProtKB P post-translational protein acetylation
GO:0006275 IMP:UniProtKB P regulation of DNA replication
GO:0007062 IEA:InterPro P sister chromatid cohesion

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_115566 Cell Cycle
REACT_152 Cell Cycle, Mitotic
REACT_150266 Establishment of Sister Chromatid Cohesion
REACT_899 S Phase

Domain Information

InterPro Annotations

Accession Description
IPR028009 N-acetyltransferase ESCO, acetyl-transferase domain
IPR028005 N-acetyltransferase ESCO, zinc-finger
IPR026656 N-acetyltransferase ESCO1

UniProt Annotations

Entry Information

Gene Name
establishment of sister chromatid cohesion N-acetyltransferase 1
Protein Entry
ESCO1_HUMAN
UniProt ID
Q5FWF5
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5FWF5-1; Sequence=Displayed; Name=2; IsoId=Q5FWF5-2; Sequence=VSP_014029, VSP_014030; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.;
Caution It is uncertain whether Met-1 or Met-2 is the initiator.
Domain The N-terminal region seems to be responsible for the association with chromosomes, thus excluding any involvement of the Zn finger in this process.
Function Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3. {ECO
Ptm Phosphorylated during mitosis. {ECO
Sequence Caution Sequence=AAH36943.1; Type=Miscellaneous discrepancy; Note=Wrong choice of frame.; Evidence= ; Sequence=BAB67804.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=BAC03483.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Similarity Belongs to the acetyltransferase family. ECO subfamily.
Subcellular Location Nucleus. Chromosome. Note=Nuclear at interphase, associated with chromosomes during mitosis.
Tissue Specificity Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle.

Identical and Related Proteins

Unique RefSeq proteins for LMP005523 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
116235478 RefSeq NP_443143 840 N-acetyltransferase ESCO1

Identical Sequences to LMP005523 proteins

Reference Database Accession Length Protein Name
GI:116235478 GenBank EAX01128.1 840 establishment of cohesion 1 homolog 1 (S. cerevisiae), isoform CRA_b [Homo sapiens]
GI:116235478 GenBank EAX01129.1 840 establishment of cohesion 1 homolog 1 (S. cerevisiae), isoform CRA_b [Homo sapiens]
GI:116235478 GenBank ACA05989.1 840 N-acetyltransferase ESCO1 variant 1 [Homo sapiens]
GI:116235478 SwissProt Q5FWF5.3 840 RecName: Full=N-acetyltransferase ESCO1; AltName: Full=CTF7 homolog 1; AltName: Full=Establishment factor-like protein 1; Short=EFO1p; Short=hEFO1; AltName: Full=Establishment of cohesion 1 homolog 1; Short=ECO1 homolog 1; Short=ESO1 homolog 1 [Homo sapiens]

Related Sequences to LMP005523 proteins

Reference Database Accession Length Protein Name
GI:116235478 DBBJ BAB67804.1 864 KIAA1911 protein, partial [Homo sapiens]
GI:116235478 DBBJ BAG10178.1 840 N-acetyltransferase ESCO1, partial [synthetic construct]
GI:116235478 GenBank AAH89426.1 840 Establishment of cohesion 1 homolog 1 (S. cerevisiae) [Homo sapiens]
GI:116235478 GenBank AHD70811.1 840 Sequence 4279 from patent US 8586006
GI:116235478 GenBank AIC57548.1 840 ESCO1, partial [synthetic construct]
GI:116235478 Third Party Genbank DAA02068.1 840 TPA_exp: establishment factor-like protein [Homo sapiens]