Gene/Proteome Database (LMPD)

LMPD ID
LMP006032
Gene ID
8202
Species
Homo sapiens (Human)
Gene Name
nuclear receptor coactivator 3
Gene Symbol
NCOA3
Synonyms
ACTR; AIB-1; AIB1; CAGH16; CTG26; KAT13B; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1; bHLHe42; pCIP
Chromosome
20
Map Location
20q12
Summary
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]
Orthologs
View orthologs and multiple alignments for NCOA3

Proteins

nuclear receptor coactivator 3 isoform a
Refseq ID NP_858045
Protein GI 32307126
UniProt ID Q9Y6Q9
mRNA ID NM_181659
Length 1424
RefSeq Status REVIEWED
MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSLSALQAISEGVGTSLLSTLSSPGPKLDNSPNMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGNVVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSHLGTKQQVFQGTNSLGLKSSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSMGGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSIPTLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSMEQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMNQMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTAGGAAVMRPMMQPQVSSQQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQPDPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLARNSSFSQQQFAHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC
nuclear receptor coactivator 3 isoform b
Refseq ID NP_006525
Protein GI 32307124
UniProt ID Q9Y6Q9
mRNA ID NM_006534
Length 1420
RefSeq Status REVIEWED
MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSLSALQAISEGVGTSLLSTLSSPGPKLDNSPNMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGNVVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSHLGTKQQVFQGTNSLGLKSSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSMGGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSIPTLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSMEQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMNQMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTAGGAAVMRPMMQPQQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQPDPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLARNSSFSQQQFAHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC
nuclear receptor coactivator 3 isoform c
Refseq ID NP_001167558
Protein GI 291490683
UniProt ID Q59EE8
mRNA ID NM_001174087
Length 1423
RefSeq Status REVIEWED
MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSLSALQAISEGVGTSLLSTLSSPGPKLDNSPNMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGNVVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSHLGTKQQVFQGTNSLGLKSSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSMGGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSIPTLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSMEQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMNQMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTAGGAAVMRPMMQPQVSSQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQPDPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLARNSSFSQQQFAHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC
nuclear receptor coactivator 3 isoform d
Refseq ID NP_001167559
Protein GI 291490685
UniProt ID Q9Y6Q9
mRNA ID NM_001174088
Length 1415
RefSeq Status REVIEWED
MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEVTSDGIFSPTAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSLSALQAISEGVGTSLLSTLSSPGPKLDNSPNMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGNVVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSHLGTKQQVFQGTNSLGLKSSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSMGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSIPTLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSMEQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMNQMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTAGGAAVMRPMMQPQQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQPDPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLARNSSFSQQQFAHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC

Gene Information

Entrez Gene ID
8202
Gene Name
nuclear receptor coactivator 3
Gene Symbol
NCOA3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0004402 IEA:InterPro F histone acetyltransferase activity
GO:0030374 IEA:InterPro F ligand-dependent nuclear receptor transcription coactivator activity
GO:0004871 IEA:InterPro F signal transducer activity
GO:0006355 IEA:UniProtKB-KW P regulation of transcription, DNA-templated
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
hsa04919 Thyroid hormone signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_116145 PPARA activates gene expression
REACT_27161 Transcriptional regulation of white adipocyte differentiation

Domain Information

InterPro Annotations

Accession Description
IPR010011 Domain of unknown function DUF1518
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR017426 Nuclear receptor coactivator
IPR028818 Nuclear receptor coactivator 3
IPR008955 Nuclear receptor coactivator Src-1
IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
IPR009110 Nuclear receptor coactivator, interlocking
IPR000014 PAS domain
IPR013767 PAS_fold
IPR014935 Steroid receptor coactivator

UniProt Annotations

Entry Information

Gene Name
nuclear receptor coactivator 3
Protein Entry
NCOA3_HUMAN
UniProt ID
Q9Y6Q9
Species
Human

Comments

Comment Type Description
Similarity Contains 1 basic helix-loop-helix (bHLH) domain.
Similarity Contains bHLH (basic helix-loop-helix) domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP006032 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
32307126 RefSeq NP_858045 1424 nuclear receptor coactivator 3 isoform a
32307124 RefSeq NP_006525 1420 nuclear receptor coactivator 3 isoform b
291490683 RefSeq NP_001167558 1423 nuclear receptor coactivator 3 isoform c
291490685 RefSeq NP_001167559 1415 nuclear receptor coactivator 3 isoform d

Identical Sequences to LMP006032 proteins

Reference Database Accession Length Protein Name
GI:291490683 DBBJ BAG10971.1 1423 nuclear receptor coactivator 3, partial [synthetic construct]
GI:32307126 GenBank AAC51849.1 1424 thyroid hormone receptor activator molecule [Homo sapiens]
GI:32307124 GenBank AAQ25082.1 1420 Sequence 4 from patent US 6562589
GI:32307124 GenBank AAI19002.1 1420 Nuclear receptor coactivator 3 [Homo sapiens]
GI:32307126 GenBank EAW75698.1 1424 nuclear receptor coactivator 3, isoform CRA_c [Homo sapiens]
GI:291490685 GenBank EAW75701.1 1415 nuclear receptor coactivator 3, isoform CRA_f [Homo sapiens]
GI:32307124 GenBank EAW75702.1 1420 nuclear receptor coactivator 3, isoform CRA_g [Homo sapiens]
GI:32307126 GenBank ABO43042.1 1424 nuclear receptor coactivator 3 [Homo sapiens]
GI:32307124 GenBank ABU31014.1 1420 Sequence 4 from patent US 7232890
GI:32307124 GenBank AHD77671.1 1420 Sequence 23800 from patent US 8586006
GI:32307126 GenBank AHD77672.1 1424 Sequence 23801 from patent US 8586006
GI:32307124 GenBank AIC50060.1 1420 NCOA3, partial [synthetic construct]
GI:32307126 SwissProt Q9Y6Q9.1 1424 RecName: Full=Nuclear receptor coactivator 3; Short=NCoA-3; AltName: Full=ACTR; AltName: Full=Amplified in breast cancer 1 protein; Short=AIB-1; AltName: Full=CBP-interacting protein; Short=pCIP; AltName: Full=Class E basic helix-loop-helix protein 42; Short=bHLHe42; AltName: Full=Receptor-associated coactivator 3; Short=RAC-3; AltName: Full=Steroid receptor coactivator protein 3; Short=SRC-3; AltName: Full=Thyroid hormone receptor activator molecule 1; Short=TRAM-1 [Homo sapiens]

Related Sequences to LMP006032 proteins

Reference Database Accession Length Protein Name
GI:32307124 DBBJ BAD93100.1 1427 nuclear receptor coactivator 3 isoform a variant, partial [Homo sapiens]
GI:291490683 DBBJ BAD93100.1 1427 nuclear receptor coactivator 3 isoform a variant, partial [Homo sapiens]
GI:32307126 DBBJ BAD93100.1 1427 nuclear receptor coactivator 3 isoform a variant, partial [Homo sapiens]
GI:32307126 DBBJ BAF82372.1 1424 unnamed protein product [Homo sapiens]
GI:32307124 DBBJ BAG10971.1 1423 nuclear receptor coactivator 3, partial [synthetic construct]
GI:32307126 DBBJ BAG10971.1 1423 nuclear receptor coactivator 3, partial [synthetic construct]
GI:291490685 GenBank AAC51677.1 1420 Amplified in Breast Cancer [Homo sapiens]
GI:32307124 GenBank AAC51849.1 1424 thyroid hormone receptor activator molecule [Homo sapiens]
GI:291490683 GenBank AAC51849.1 1424 thyroid hormone receptor activator molecule [Homo sapiens]
GI:291490685 GenBank AAB92368.1 1412 nuclear receptor coactivator [Homo sapiens]
GI:291490685 GenBank AAI19002.1 1420 Nuclear receptor coactivator 3 [Homo sapiens]
GI:32307124 GenBank EAW75698.1 1424 nuclear receptor coactivator 3, isoform CRA_c [Homo sapiens]
GI:291490683 GenBank EAW75698.1 1424 nuclear receptor coactivator 3, isoform CRA_c [Homo sapiens]
GI:291490685 GenBank EAW75702.1 1420 nuclear receptor coactivator 3, isoform CRA_g [Homo sapiens]
GI:291490683 GenBank ABO43042.1 1424 nuclear receptor coactivator 3 [Homo sapiens]
GI:32307126 GenBank ABU31014.1 1420 Sequence 4 from patent US 7232890
GI:291490685 GenBank ABU31014.1 1420 Sequence 4 from patent US 7232890
GI:291490683 GenBank AHD77672.1 1424 Sequence 23801 from patent US 8586006
GI:291490685 GenBank AIC50060.1 1420 NCOA3, partial [synthetic construct]
GI:32307126 GenBank AIC50060.1 1420 NCOA3, partial [synthetic construct]
GI:32307124 RefSeq NP_858045.1 1424 nuclear receptor coactivator 3 isoform a [Homo sapiens]
GI:291490683 RefSeq NP_858045.1 1424 nuclear receptor coactivator 3 isoform a [Homo sapiens]
GI:32307126 RefSeq NP_001167558.1 1423 nuclear receptor coactivator 3 isoform c [Homo sapiens]
GI:32307124 RefSeq NP_001167558.1 1423 nuclear receptor coactivator 3 isoform c [Homo sapiens]