Gene/Proteome Database (LMPD)

LMPD ID
LMP006077
Gene ID
56209
Species
Mus musculus (Mouse)
Gene Name
glycerophosphodiester phosphodiesterase 1
Gene Symbol
Gde1
Synonyms
1200003M13Rik; Mir16; RGS16
Alternate Names
glycerophosphodiester phosphodiesterase 1; membrane interacting protein of RGS16; membrane-interacting protein of RGS16
Chromosome
7
Map Location
7|7 F3
EC Number
3.1.4.44

Proteins

glycerophosphodiester phosphodiesterase 1
Refseq ID NP_062526
Protein GI 9625018
UniProt ID Q9JL56
mRNA ID NM_019580
Length 331
RefSeq Status PROVISIONAL
MWLWEDQGGLLGPFSFVLVLLLVVTRSPFNACVLTGSLYILLRFFSFEPVPSRRALQVLKPRDRVSAIAHRGGSHDAPENTLAAIRQAAKNGATGVELDIEFTSDGVPVLMHDNTVDRTTDGSGRLCDLTFEQVRKLNPAANHRLRNEFPDERIPTLKEAVTECLRHNLTIFFDVKGHADMASAALKNIYTEFPQLYNNSMVCSFLPEVIYKMRQTDQKVITALTHRPWSLSHTGDGKPRYSVFWKQSVFVVLDILLDWSMHNVLWYLCGISAFLMQKDFVSPDYLKKWSAKGIQVVSWTVNTFDEKNYYESHLGSSYITDSMLEDCAPHF

Gene Information

Entrez Gene ID
56209
Gene Name
glycerophosphodiester phosphodiesterase 1
Gene Symbol
Gde1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005887 ISS:MGI C integral component of plasma membrane
GO:0008889 ISS:MGI F glycerophosphodiester phosphodiesterase activity
GO:0047395 IEA:UniProtKB-EC F glycerophosphoinositol glycerophosphodiesterase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0007186 ISO:MGI P G-protein coupled receptor signaling pathway
GO:0006071 IEA:InterPro P glycerol metabolic process
GO:0006629 IEA:InterPro P lipid metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR004129 Glycerophosphoryl diester phosphodiesterase
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

UniProt Annotations

Entry Information

Gene Name
glycerophosphodiester phosphodiesterase 1
Protein Entry
GDE1_MOUSE
UniProt ID
Q9JL56
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = myo-inositol + sn-glycerol 3-phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Function Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity). {ECO:0000250}.
Ptm N-glycosylated. {ECO:0000250}.
Similarity Belongs to the glycerophosphoryl diester phosphodiesterase family. {ECO:0000305}.
Similarity Contains 1 GP-PDE domain. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Perinuclear vesicles and cell membrane. {ECO:0000250}.
Subunit Interacts with PRAF2 and RGS16. {ECO:0000250}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:10760272}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006077 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9625018 RefSeq NP_062526 331 glycerophosphodiester phosphodiesterase 1

Identical Sequences to LMP006077 proteins

Reference Database Accession Length Protein Name
GI:9625018 DBBJ BAB23975.1 331 unnamed protein product [Mus musculus]
GI:9625018 GenBank AAF65232.1 331 membrane interacting protein of RGS16 [Mus musculus]
GI:9625018 GenBank AAH03902.1 331 Glycerophosphodiester phosphodiesterase 1 [Mus musculus]
GI:9625018 GenBank EDL17137.1 331 membrane interacting protein of RGS16, isoform CRA_c [Mus musculus]
GI:9625018 SwissProt Q9JL56.1 331 RecName: Full=Glycerophosphodiester phosphodiesterase 1; AltName: Full=Membrane-interacting protein of RGS16 [Mus musculus]

Related Sequences to LMP006077 proteins

Reference Database Accession Length Protein Name
GI:9625018 DBBJ BAE29870.1 331 unnamed protein product [Mus musculus]
GI:9625018 GenBank AAF65233.1 331 membrane interacting protein of RGS16 [Rattus norvegicus]
GI:9625018 GenBank AAH70897.1 331 Glycerophosphodiester phosphodiesterase 1 [Rattus norvegicus]
GI:9625018 GenBank EDM17698.1 331 membrane interacting protein of RGS16, isoform CRA_b [Rattus norvegicus]
GI:9625018 RefSeq NP_116004.2 331 glycerophosphodiester phosphodiesterase 1 [Rattus norvegicus]
GI:9625018 SwissProt Q9JL55.2 331 RecName: Full=Glycerophosphodiester phosphodiesterase 1; AltName: Full=Membrane-interacting protein of RGS16 [Rattus norvegicus]