Gene/Proteome Database (LMPD)

LMPD ID
LMP006330
Gene ID
17850
Species
Mus musculus (Mouse)
Gene Name
methylmalonyl-Coenzyme A mutase
Gene Symbol
Mut
Synonyms
D230010K02Rik; Mcm
Alternate Names
methylmalonyl-CoA mutase, mitochondrial; methylmalonyl-CoA isomerase
Chromosome
17
Map Location
17 C-D|17 19.55 cM
EC Number
5.4.99.2

Proteins

methylmalonyl-CoA mutase, mitochondrial precursor
Refseq ID NP_032676
Protein GI 148540106
UniProt ID P16332
mRNA ID NM_008650
Length 748
RefSeq Status VALIDATED
MLRAKNQLFLLSPHYLKQLNIPSASRWKRLLHQQQPLHPEWAVLAKKQLKGKNPEDLIWHTPEGISIKPLYSRADTLDLPEELPGVKPFTRGPYPTMYTYRPWTIRQYAGFSTVEESNKFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRGDVGMAGVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPVLATFIVTGEEQGVPKEKLTGTIQNDILKEFMVRNTYIFPPEPSMKIIADIFQYTAQHMPKFNSISISGYHMQEAGADAILELAYTIADGLEYCRTGLQAGLTIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFQPKNSKSLLLRAHCQTSGWSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGLPTVKSARIARNTQIIIQEESGIPKVADPWGGSYMMESLTNDVYEAALKLIYEVEEMGGMAKAVAEGIPKLRIEECAARRQARIDSGSEVIVGVNKYQLEKEDSVEVLAIDNTSVRKKQIEKLKKIKSSRDQALAEQCLSALTQCAASGDGNILALAVDAARARCTVGEITDALKKVFGEHKANDRMVSGAYRQEFGESKEITSAIKRVNKFMEREGRRPRLLVAKMGQDGHDRGAKVIATGFADLGFDVDIGPLFQTPREVAQQAVDADVHAVGVSTLAAGHKTLVPELIKELTALGRPDILVMCGGVIPPQDYEFLYEVGVSNVFGPGTRIPRAAVQVLDDIEKCLAEKQQSV
transit_peptide: 1..30 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (P16332.2) calculated_mol_wt: 3623 peptide sequence: MLRAKNQLFLLSPHYLKQLNIPSASRWKRL mat_peptide: 31..748 product: Methylmalonyl-CoA mutase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P16332.2) calculated_mol_wt: 79239 peptide sequence: LHQQQPLHPEWAVLAKKQLKGKNPEDLIWHTPEGISIKPLYSRADTLDLPEELPGVKPFTRGPYPTMYTYRPWTIRQYAGFSTVEESNKFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRGDVGMAGVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPVLATFIVTGEEQGVPKEKLTGTIQNDILKEFMVRNTYIFPPEPSMKIIADIFQYTAQHMPKFNSISISGYHMQEAGADAILELAYTIADGLEYCRTGLQAGLTIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFQPKNSKSLLLRAHCQTSGWSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGLPTVKSARIARNTQIIIQEESGIPKVADPWGGSYMMESLTNDVYEAALKLIYEVEEMGGMAKAVAEGIPKLRIEECAARRQARIDSGSEVIVGVNKYQLEKEDSVEVLAIDNTSVRKKQIEKLKKIKSSRDQALAEQCLSALTQCAASGDGNILALAVDAARARCTVGEITDALKKVFGEHKANDRMVSGAYRQEFGESKEITSAIKRVNKFMEREGRRPRLLVAKMGQDGHDRGAKVIATGFADLGFDVDIGPLFQTPREVAQQAVDADVHAVGVSTLAAGHKTLVPELIKELTALGRPDILVMCGGVIPPQDYEFLYEVGVSNVFGPGTRIPRAAVQVLDDIEKCLAEKQQSV

Gene Information

Entrez Gene ID
17850
Gene Name
methylmalonyl-Coenzyme A mutase
Gene Symbol
Mut
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:MGI C mitochondrion
GO:0031419 IEA:UniProtKB-KW F cobalamin binding
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004494 IDA:MGI F methylmalonyl-CoA mutase activity
GO:0072341 IEA:Ensembl F modified amino acid binding
GO:0050667 IEA:Ensembl P homocysteine metabolic process
GO:0009791 IMP:MGI P post-embryonic development

KEGG Pathway Links

KEGG Pathway ID Description
mmu01200 Carbon metabolism
mmu00630 Glyoxylate and dicarboxylate metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-0 isoleucine degradation

Domain Information

InterPro Annotations

Accession Description
IPR006158 Cobalamin (vitamin B12)-binding domain
IPR016176 Cobalamin (vitamin B12)-dependent enzyme, catalytic
IPR014348 Cobalamin (vitamin B12)-dependent enzyme, catalytic subdomain
IPR006159 Methylmalonyl-CoA mutase, C-terminal
IPR006098 Methylmalonyl-CoA mutase, alpha chain, catalytic
IPR006099 Methylmalonyl-CoA mutase, alpha/beta chain, catalytic

UniProt Annotations

Entry Information

Gene Name
methylmalonyl-Coenzyme A mutase
Protein Entry
MUTA_MOUSE
UniProt ID
P16332
Species
Mouse

Comments

Comment Type Description
Catalytic Activity (R)-methylmalonyl-CoA = succinyl-CoA.
Cofactor Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
Function Involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. {ECO:0000250}.
Similarity Belongs to the methylmalonyl-CoA mutase family. {ECO:0000305}.
Similarity Contains 1 B12-binding domain. {ECO:0000255|PROSITE- ProRule:PRU00666}.
Subcellular Location Mitochondrion matrix.
Subunit Homodimer.

Identical and Related Proteins

Unique RefSeq proteins for LMP006330 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
148540106 RefSeq NP_032676 748 methylmalonyl-CoA mutase, mitochondrial precursor

Identical Sequences to LMP006330 proteins

Reference Database Accession Length Protein Name
GI:148540106 DBBJ BAE27064.1 748 unnamed protein product [Mus musculus]
GI:148540106 GenBank EDL23389.1 748 methylmalonyl-Coenzyme A mutase [Mus musculus]
GI:148540106 SwissProt P16332.2 748 RecName: Full=Methylmalonyl-CoA mutase, mitochondrial; Short=MCM; AltName: Full=Methylmalonyl-CoA isomerase; Flags: Precursor [Mus musculus]

Related Sequences to LMP006330 proteins

Reference Database Accession Length Protein Name
GI:148540106 GenBank AAH19175.1 748 Mut protein [Mus musculus]
GI:148540106 GenBank EDM18677.1 748 rCG43751 [Rattus norvegicus]
GI:148540106 RefSeq XP_005072350.1 748 PREDICTED: methylmalonyl-CoA mutase, mitochondrial [Mesocricetus auratus]
GI:148540106 RefSeq XP_005359842.1 748 PREDICTED: methylmalonyl-CoA mutase, mitochondrial [Microtus ochrogaster]
GI:148540106 RefSeq XP_003754543.2 833 PREDICTED: methylmalonyl-CoA mutase, mitochondrial [Rattus norvegicus]
GI:148540106 RefSeq XP_001067239.3 833 PREDICTED: methylmalonyl-CoA mutase, mitochondrial [Rattus norvegicus]