Gene/Proteome Database (LMPD)

LMPD ID
LMP006459
Gene ID
23678
Species
Homo sapiens (Human)
Gene Name
serum/glucocorticoid regulated kinase family, member 3
Gene Symbol
SGK3
Synonyms
CISK; SGK2; SGKL
Chromosome
8
Map Location
8q12
Summary
This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for SGK3

Proteins

serine/threonine-protein kinase Sgk3 isoform 1
Refseq ID NP_037389
Protein GI 31563382
UniProt ID Q53EW6
mRNA ID NM_013257
Length 496
RefSeq Status REVIEWED
MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNTLKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL
serine/threonine-protein kinase Sgk3 isoform 1
Refseq ID NP_001028750
Protein GI 75813626
UniProt ID Q5H9Q5
mRNA ID NM_001033578
Length 496
RefSeq Status REVIEWED
Protein sequence is identical to GI:31563382 (mRNA isoform)
serine/threonine-protein kinase Sgk3 isoform 2
Refseq ID NP_733827
Protein GI 31563383
UniProt ID Q53EW6
mRNA ID NM_170709
Length 464
RefSeq Status REVIEWED
MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNTLKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL

Gene Information

Entrez Gene ID
23678
Gene Name
serum/glucocorticoid regulated kinase family, member 3
Gene Symbol
SGK3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0035091 IEA:InterPro F phosphatidylinositol binding
GO:0004674 IEA:UniProtKB-KW F protein serine/threonine kinase activity

KEGG Pathway Links

KEGG Pathway ID Description
hsa04068 FoxO signaling pathway
hsa04151 PI3K-Akt signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_160189 Stimuli-sensing channels

Domain Information

InterPro Annotations

Accession Description
IPR000961 AGC-kinase, C-terminal
IPR001683 Phox homologous domain
IPR017441 Protein kinase, ATP binding site
IPR017892 Protein kinase, C-terminal
IPR000719 Protein kinase domain
IPR011009 Protein kinase-like domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008271 Serine/threonine-protein kinase, active site

UniProt Annotations

Entry Information

Gene Name
serum/glucocorticoid regulated kinase family, member 3
Protein Entry
SGK3_HUMAN
UniProt ID
Q5H9Q5
Species
Human

Comments

Comment Type Description
Catalytic Activity ATP + a protein = ADP + a phosphoprotein.
Similarity Contains AGC-kinase C-terminal domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP006459 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31563382 RefSeq NP_037389 496 serine/threonine-protein kinase Sgk3 isoform 1
31563383 RefSeq NP_733827 464 serine/threonine-protein kinase Sgk3 isoform 2

Identical Sequences to LMP006459 proteins

Reference Database Accession Length Protein Name
GI:31563383 DBBJ BAG51984.1 464 unnamed protein product [Homo sapiens]
GI:31563383 EMBL CAF86721.1 464 unnamed protein product [Homo sapiens]
GI:31563382 GenBank AHD73908.1 496 Sequence 12366 from patent US 8586006
GI:31563382 GenBank AHD73909.1 496 Sequence 12367 from patent US 8586006
GI:31563383 GenBank AHD73910.1 464 Sequence 12368 from patent US 8586006
GI:31563382 GenBank AIC51022.1 496 SGK3, partial [synthetic construct]
GI:31563382 GenBank AIC62717.1 496 SGK3, partial [synthetic construct]
GI:31563383 RefSeq XP_003274840.1 464 PREDICTED: serine/threonine-protein kinase Sgk3 isoform 2 [Nomascus leucogenys]
GI:31563382 RefSeq XP_003831405.1 496 PREDICTED: serine/threonine-protein kinase Sgk3 isoform X1 [Pan paniscus]
GI:31563382 RefSeq XP_008954969.1 496 PREDICTED: serine/threonine-protein kinase Sgk3 isoform X1 [Pan paniscus]

Related Sequences to LMP006459 proteins

Reference Database Accession Length Protein Name
GI:31563382 EMBL CAI45969.1 496 hypothetical protein [Homo sapiens]
GI:31563383 GenBank AAH15326.1 496 Serum/glucocorticoid regulated kinase family, member 3 [Homo sapiens]
GI:31563382 GenBank AAQ02420.1 497 serum/glucocorticoid regulated kinase-like, partial [synthetic construct]
GI:31563383 RefSeq NP_037389.4 496 serine/threonine-protein kinase Sgk3 isoform 1 [Homo sapiens]
GI:31563383 RefSeq NP_001028750.1 496 serine/threonine-protein kinase Sgk3 isoform 1 [Homo sapiens]
GI:31563383 RefSeq NP_001127544.1 496 serine/threonine-protein kinase Sgk3 [Pongo abelii]
GI:31563382 RefSeq XP_003902874.1 496 PREDICTED: serine/threonine-protein kinase Sgk3 isoform X1 [Papio anubis]
GI:31563383 RefSeq XP_004588084.1 464 PREDICTED: serine/threonine-protein kinase Sgk3 isoform X3 [Ochotona princeps]
GI:31563382 RefSeq XP_007998977.1 496 PREDICTED: serine/threonine-protein kinase Sgk3 isoform X1 [Chlorocebus sabaeus]
GI:31563382 RefSeq XP_007998978.1 496 PREDICTED: serine/threonine-protein kinase Sgk3 isoform X1 [Chlorocebus sabaeus]
GI:31563382 RefSeq XP_007998979.1 496 PREDICTED: serine/threonine-protein kinase Sgk3 isoform X1 [Chlorocebus sabaeus]
GI:31563383 SwissProt Q5R7A7.1 496 RecName: Full=Serine/threonine-protein kinase Sgk3; AltName: Full=Serum/glucocorticoid-regulated kinase 3 [Pongo abelii]