Gene/Proteome Database (LMPD)
LMPD ID
LMP006568
Gene ID
Species
Mus musculus (Mouse)
Gene Name
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
Gene Symbol
Synonyms
6332404G05Rik; DLTA; PDC-E2
Alternate Names
dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; PDCE2; pyruvate dehydrogenase complex component E2; dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
Chromosome
9
Map Location
9 A5.3|9
EC Number
2.3.1.12
Proteins
| dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial | |
|---|---|
| Refseq ID | NP_663589 |
| Protein GI | 257796245 |
| UniProt ID | Q8BMF4 |
| mRNA ID | NM_145614 |
| Length | 642 |
| RefSeq Status | VALIDATED |
| MWRVCARRARSAVPRDGFRARWAALKEGPGAPCGSPRIGPAAVRCGSGIPRYGVRSLCGWSSGSGTVPRNRLLRQLLGSPSRRSYSLPPHQKVPLPSLSPTMQAGTIARWEKKEGEKISEGDLIAEVETDKATVGFESLEECYMAKILVPEGTRDVPVGSIICITVEKPQDIEAFKNYTLDLAAAAAPQAAPAAAPAPAAAPAAPSASAPGSSYPTHMQIVLPALSPTMTMGTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGAPLCIIVEKQEDIAAFADYRPTEVTSLKPQAAPPAPPPVAAVPPTPQPVAPTPSAAPAGPKGRVFVSPLAKKLAAEKGIDLTQVKGTGPEGRIIKKDIDSFVPSKAAPAAAAAMAPPGPRVAPAPAGVFTDIPISNIRRVIAQRLMQSKQTIPHYYLSVDVNMGEVLLVRKELNKMLEGKGKISVNDFIIKASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGLETIASDVVSLASKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAIINPPQACILAIGASEDKLIPADNEKGFDVASVMSVTLSCDHRVVDGAVGAQWLAEFKKYLEKPITMLL | |
| transit_peptide: 1..85 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q8BMF4.2) calculated_mol_wt: 9182 peptide sequence: MWRVCARRARSAVPRDGFRARWAALKEGPGAPCGSPRIGPAAVRCGSGIPRYGVRSLCGWSSGSGTVPRNRLLRQLLGSPSRRSY mat_peptide: 86..642 product: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8BMF4.2) calculated_mol_wt: 58778 peptide sequence: SLPPHQKVPLPSLSPTMQAGTIARWEKKEGEKISEGDLIAEVETDKATVGFESLEECYMAKILVPEGTRDVPVGSIICITVEKPQDIEAFKNYTLDLAAAAAPQAAPAAAPAPAAAPAAPSASAPGSSYPTHMQIVLPALSPTMTMGTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGAPLCIIVEKQEDIAAFADYRPTEVTSLKPQAAPPAPPPVAAVPPTPQPVAPTPSAAPAGPKGRVFVSPLAKKLAAEKGIDLTQVKGTGPEGRIIKKDIDSFVPSKAAPAAAAAMAPPGPRVAPAPAGVFTDIPISNIRRVIAQRLMQSKQTIPHYYLSVDVNMGEVLLVRKELNKMLEGKGKISVNDFIIKASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGLETIASDVVSLASKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAIINPPQACILAIGASEDKLIPADNEKGFDVASVMSVTLSCDHRVVDGAVGAQWLAEFKKYLEKPITMLL | |
Gene Information
Entrez Gene ID
Gene Name
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005967 | TAS:MGI | C | mitochondrial pyruvate dehydrogenase complex |
| GO:0005739 | IDA:MGI | C | mitochondrion |
| GO:0045254 | TAS:MGI | C | pyruvate dehydrogenase complex |
| GO:0004742 | TAS:MGI | F | dihydrolipoyllysine-residue acetyltransferase activity |
| GO:0006086 | IC:MGI | P | acetyl-CoA biosynthetic process from pyruvate |
| GO:0006006 | IEA:UniProtKB-KW | P | glucose metabolic process |
| GO:0006099 | IEA:UniProtKB-KW | P | tricarboxylic acid cycle |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR003016 | 2-oxo acid dehydrogenase, lipoyl-binding site |
| IPR001078 | 2-oxoacid dehydrogenase acyltransferase, catalytic domain |
| IPR000089 | Biotin/lipoyl attachment |
| IPR023213 | Chloramphenicol acetyltransferase-like domain |
| IPR006257 | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex |
| IPR004167 | E3-binding domain |
| IPR011053 | Single hybrid motif |
UniProt Annotations
Entry Information
Gene Name
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
Protein Entry
ODP2_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine. |
| Cofactor | Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Evidence={ECO:0000250}; Note=Binds 1 lipoyl cofactor covalently. {ECO:0000250}; |
| Function | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000250}. |
| Similarity | Belongs to the 2-oxoacid dehydrogenase family. {ECO:0000305}. |
| Similarity | Contains 2 lipoyl-binding domains. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}. |
| Subcellular Location | Mitochondrion matrix. |
| Subunit | Part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules. Interacts with PDK2 and PDK3 (By similarity). {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006568 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 257796245 | RefSeq | NP_663589 | 642 | dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial |
Identical Sequences to LMP006568 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:257796245 | GenBank | AAH26680.1 | 642 | Dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) [Mus musculus] |
| GI:257796245 | GenBank | AAH69862.1 | 642 | Dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) [Mus musculus] |
| GI:257796245 | GenBank | EDL25751.1 | 642 | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) [Mus musculus] |
| GI:257796245 | SwissProt | Q8BMF4.2 | 642 | RecName: Full=Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; AltName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; AltName: Full=Pyruvate dehydrogenase complex component E2; Short=PDC-E2; Short=PDCE2; Flags: Precursor [Mus musculus] |
Related Sequences to LMP006568 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:257796245 | DBBJ | BAC27715.1 | 642 | unnamed protein product [Mus musculus] |
| GI:257796245 | GenBank | AAH31495.1 | 642 | Dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) [Mus musculus] |
| GI:257796245 | GenBank | AAI07441.1 | 632 | Dihydrolipoamide S-acetyltransferase [Rattus norvegicus] |
| GI:257796245 | GenBank | EDL95470.1 | 632 | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) [Rattus norvegicus] |
| GI:257796245 | RefSeq | NP_112287.1 | 632 | dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial [Rattus norvegicus] |
| GI:257796245 | SwissProt | P08461.3 | 632 | RecName: Full=Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; AltName: Full=70 kDa mitochondrial autoantigen of primary biliary cirrhosis; Short=PBC; AltName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; AltName: Full=Pyruvate dehydrogenase complex component E2; Short=PDC-E2; Short=PDCE2; Flags: Precursor [Rattus norvegicus] |