Gene/Proteome Database (LMPD)

LMPD ID
LMP006579
Gene ID
238023
Species
Mus musculus (Mouse)
Gene Name
hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
Gene Symbol
Hexdc
Synonyms
BC069960
Alternate Names
hexosaminidase D; beta-hexosaminidase D; beta-N-acetylhexosaminidase; N-acetyl-beta-galactosaminidase; hexosaminidase domain-containing protein
Chromosome
11
Map Location
11 E2|11
EC Number
3.2.1.52

Proteins

hexosaminidase D isoform 1
Refseq ID NP_001139545
Protein GI 225703123
UniProt ID Q3U4H6
mRNA ID NM_001146073
Length 559
RefSeq Status VALIDATED
MSSPTPFKMRLVHLDLKGAPPKVSYLSEVFPLFHALGANGLLIEYEDMFPYEGHLRLLRAKHAYSPSEVTEILRLARLSELEVIPLVQTFGHMEFVLKHAAFAHLREVALFPNTLNPHEAESLALVQAMIDQILELHRDVRWLHIGCDEVYYLGEGETSKQWLQQEQNSHAKLCLSHMQAVASHVLTQHPGVTPLVWDDMLRDIPQEQLKASGVPQLVEPVLWDYGADLDVHGKVFLIGKYQECGFQRLWAASAFKGATGASQALPPVEHHIRNHELWLQVAGSGPKDALQGIILTGWQRYDHFSVLCELLPVGIPSLAACLQSLVHGALDYSASEPGHLYMDCVVRPGAPADCAATTFHMFTGKQPPGLAGAPQDAVPFAHSTQRSGVLSEHFCLWTVSGGFAEDVRLRAERFLGVSSLEIADTVSEGAGSFPGSDIHALVTQISLHLRSSVDTLLERNRYVTGWFSPYHRRRKLVHPVMIQHIQPEALSLLSRWNNLVQQLEVALQPVFYPDTIEEWLEENVLPSLQRLQDLLQDLGEAAARQPPPTSPGWDTGQNP
hexosaminidase D isoform 2
Refseq ID NP_001001333
Protein GI 225703121
UniProt ID Q3U4H6
mRNA ID NM_001001333
Length 486
RefSeq Status VALIDATED
MSSPTPFKMRLVHLDLKGAPPKVSYLSEVFPLFHALGANGLLIEYEDMFPYEGHLRLLRAKHAYSPSEVTEILRLARLSELEVIPLVQTFGHMEFVLKHAAFAHLREVALFPNTLNPHEAESLALVQAMIDQILELHRDVRWLHIGCDEVYYLGEGETSKQWLQQEQNSHAKLCLSHMQAVASHVLTQHPGVTPLVWDDMLRDIPQEQLKASGVPQLVEPVLWDYGADLDVHGKVFLIGKYQECGFQRLWAASAFKGATGASQALPPVEHHIRNHELWLQVAGSGPKDALQGIILTGWQRYDHFSVLCELLPVGIPSLAACLQSLVHGGFAEDVRLRAERFLGVSSLEIADTVSEGAGSFPGSDIHALVTQISLHLRSSVDTLLERNRYVTGWFSPYHRRRKLVHPVMIQHIQPEALSLLSRWNNLVQQLEVALQPVFYPDTIEEWLEENVLPSLQRLQDLLQDLGEAAARQPPPTSPGWDTGQNP

Gene Information

Entrez Gene ID
238023
Gene Name
hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
Gene Symbol
Hexdc
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0004563 IEA:UniProtKB-EC F beta-N-acetylhexosaminidase activity
GO:0005975 IEA:InterPro P carbohydrate metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00511 Other glycan degradation
mmu00511 Other glycan degradation

Domain Information

InterPro Annotations

Accession Description
IPR015883 Glycoside hydrolase family 20, catalytic core
IPR017853 Glycoside hydrolase superfamily
IPR013781 Glycoside hydrolase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
Protein Entry
HEXDC_MOUSE
UniProt ID
Q3U4H6
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3U4H6-1; Sequence=Displayed; Name=2; IsoId=Q3U4H6-2; Sequence=VSP_030778; Note=No experimental confirmation available.;
Biophysicochemical Properties Kinetic parameters: KM=0.25 mM for p-nitrophenyl-beta-N-acetylgalactosaminide {ECO:0000269|PubMed:19040401}; pH dependence: Optimum pH is 5.5. {ECO:0000269|PubMed:19040401}; Temperature dependence: Optimum temperature is 37 degrees Celsius. {ECO:0000269|PubMed:19040401};
Catalytic Activity Hydrolysis of terminal non-reducing N-acetyl- D-hexosamine residues in N-acetyl-beta-D-hexosaminides. {ECO:0000269|PubMed:19040401}.
Enzyme Regulation Inhibited by O-(2-acetamido-2-deoxy-D- glucopyranosylidene)amino N-phenylcarbamate (PUGNAc). {ECO:0000269|PubMed:19040401}.
Function Has hexosaminidase activity. {ECO:0000269|PubMed:19040401}.
Sequence Caution Sequence=AAH69960.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the glycosyl hydrolase 20 family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19040401}. Nucleus {ECO:0000269|PubMed:19040401}.
Subunit Homodimer; disulfide-linked. {ECO:0000269|PubMed:19040401}.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:19040401}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006579 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
225703123 RefSeq NP_001139545 559 hexosaminidase D isoform 1
225703121 RefSeq NP_001001333 486 hexosaminidase D isoform 2

Identical Sequences to LMP006579 proteins

Reference Database Accession Length Protein Name
GI:225703121 DBBJ BAE32455.1 486 unnamed protein product [Mus musculus]
GI:225703121 EMBL CAR57923.1 486 hexosaminidase D [Mus musculus]
GI:225703123 RefSeq XP_006533327.1 559 PREDICTED: hexosaminidase D isoform X5 [Mus musculus]
GI:225703123 RefSeq XP_006533328.1 559 PREDICTED: hexosaminidase D isoform X6 [Mus musculus]
GI:225703123 RefSeq XP_006533329.1 559 PREDICTED: hexosaminidase D isoform X7 [Mus musculus]
GI:225703123 RefSeq XP_006533330.1 559 PREDICTED: hexosaminidase D isoform X8 [Mus musculus]
GI:225703123 RefSeq XP_006533331.1 559 PREDICTED: hexosaminidase D isoform X9 [Mus musculus]
GI:225703123 RefSeq XP_006533332.1 559 PREDICTED: hexosaminidase D isoform X10 [Mus musculus]
GI:225703121 SwissProt Q3U4H6.1 486 RecName: Full=Hexosaminidase D; AltName: Full=Beta-N-acetylhexosaminidase; AltName: Full=Beta-hexosaminidase D; AltName: Full=Hexosaminidase domain-containing protein; AltName: Full=N-acetyl-beta-galactosaminidase [Mus musculus]

Related Sequences to LMP006579 proteins

Reference Database Accession Length Protein Name
GI:225703123 GenBank AAH69960.1 467 Hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing [Mus musculus]
GI:225703121 RefSeq NP_001136034.2 486 hexosaminidase D [Rattus norvegicus]
GI:225703121 RefSeq XP_005069836.1 486 PREDICTED: hexosaminidase D [Mesocricetus auratus]
GI:225703121 RefSeq XP_006247922.1 486 PREDICTED: hexosaminidase D isoform X1 [Rattus norvegicus]
GI:225703123 RefSeq XP_006533323.1 608 PREDICTED: hexosaminidase D isoform X1 [Mus musculus]
GI:225703123 RefSeq XP_006533324.1 582 PREDICTED: hexosaminidase D isoform X2 [Mus musculus]
GI:225703123 RefSeq XP_006533325.1 578 PREDICTED: hexosaminidase D isoform X3 [Mus musculus]
GI:225703123 RefSeq XP_006533326.1 574 PREDICTED: hexosaminidase D isoform X4 [Mus musculus]
GI:225703121 RefSeq XP_006533333.1 535 PREDICTED: hexosaminidase D isoform X11 [Mus musculus]
GI:225703123 RefSeq XP_006912406.1 545 PREDICTED: hexosaminidase D [Pteropus alecto]
GI:225703121 RefSeq XP_006987695.1 486 PREDICTED: hexosaminidase D isoform X1 [Peromyscus maniculatus bairdii]
GI:225703121 RefSeq XP_008766721.1 486 PREDICTED: hexosaminidase D isoform X1 [Rattus norvegicus]