Gene/Proteome Database (LMPD)

LMPD ID
LMP006601
Gene ID
108105
Species
Mus musculus (Mouse)
Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Gene Symbol
B3gnt5
Synonyms
beta3GnT5
Alternate Names
lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; BGnT-5; beta3Gn-T5; lc3 synthase; beta-1,3-Gn-T5; lc(3)Cer synthase; lactotriaosylceramide synthase; beta-1,3-N-acetylglucosaminyltransferase 5; UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5
Chromosome
16
Map Location
16|16 B1
EC Number
2.4.1.206

Proteins

lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
Refseq ID NP_001152879
Protein GI 226874881
UniProt ID Q8BGY6
mRNA ID NM_001159407
Length 376
RefSeq Status VALIDATED
MRLFVSRRVKRWKIFHFFVTCFILSFMVFWSPINNYIMSHMKSYSYRYLVNSYGFVNNSLSLKHSSVQPHYPYLINHREKCQAQDVLLLLFIKTAPENYGRRSAIRKTWGNENYVQSQLNANIKILFALGTPGPLKGKELQKRLIGEDQVYKDIIQQDFIDSFHNLTSKFLLQFSWANTFCPHAKFLMTADDDIFIHMPNLIEYLQGLEQIGVRDFWIGHVHRGGPPVRDKSSKYYVPYEMYKWPAYPDYTAGAAYVVSRDVAAKIYEASQTLNSSMYIDDVFMGLCANKVGILPQDHVFFSGEGKIPYHPCIYEKMMTSHGHLQDLQDLWIEATHPKVKNISKGFFGQIYCRLIKIVLLCRLTYRNSYPCWAAFA
lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
Refseq ID NP_473393
Protein GI 31542177
UniProt ID Q8BGY6
mRNA ID NM_054052
Length 376
RefSeq Status VALIDATED
Protein sequence is identical to GI:226874881 (mRNA isoform)
lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
Refseq ID NP_001152880
Protein GI 226874883
UniProt ID Q8BGY6
mRNA ID NM_001159408
Length 376
RefSeq Status VALIDATED
Protein sequence is identical to GI:226874881 (mRNA isoform)

Gene Information

Entrez Gene ID
108105
Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Gene Symbol
B3gnt5
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005622 ISS:UniProtKB C intracellular
GO:0008457 ISS:UniProtKB F beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity
GO:0008378 IEA:InterPro F galactosyltransferase activity
GO:0047256 IEA:UniProtKB-EC F lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity
GO:0008917 IDA:MGI F lipopolysaccharide N-acetylglucosaminyltransferase activity
GO:0007417 ISS:UniProtKB P central nervous system development
GO:0009103 IDA:GOC P lipopolysaccharide biosynthetic process
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation
GO:0030148 TAS:MGI P sphingolipid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00601 Glycosphingolipid biosynthesis - lacto and neolacto series
mmu01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR002659 Glycosyl transferase, family 31

UniProt Annotations

Entry Information

Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Protein Entry
B3GN5_MOUSE
UniProt ID
Q8BGY6
Species
Mouse

Comments

Comment Type Description
Catalytic Activity UDP-N-acetyl-D-glucosamine + beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N- acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D- glucosyl-(1<->1)-ceramide. {ECO:0000269|PubMed:11384981}.
Developmental Stage Mainly expressed during embryonic development. Expressed in most tissues at embryonic day 11 with elevated expression in the developing central nervous system. {ECO:0000269|PubMed:11384981}.
Function Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 31 family. {ECO:0000305}.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue Specificity Highly expressed in adult spleen, placenta and cerebellar Purkinje cells where it colocalized with HNK-1. Expressed at lower level in brain, lung, thymus and muscle. {ECO:0000269|PubMed:11384981}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006601 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
226874881 RefSeq NP_001152879 376 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

Identical Sequences to LMP006601 proteins

Reference Database Accession Length Protein Name
GI:226874881 GenBank AAH63076.1 376 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 [Mus musculus]
GI:226874881 GenBank EDK97556.1 376 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 [Mus musculus]
GI:226874881 RefSeq NP_001152880.1 376 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase [Mus musculus]
GI:226874881 RefSeq XP_006521769.1 376 PREDICTED: lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase isoform X1 [Mus musculus]
GI:226874881 RefSeq XP_006521770.1 376 PREDICTED: lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase isoform X2 [Mus musculus]
GI:226874881 SwissProt Q8BGY6.1 376 RecName: Full=Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; AltName: Full=Lactotriaosylceramide synthase; Short=Lc(3)Cer synthase; Short=Lc3 synthase; AltName: Full=UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5; Short=BGnT-5; Short=Beta-1,3-Gn-T5; Short=Beta-1,3-N-acetylglucosaminyltransferase 5; Short=Beta3Gn-T5 [Mus musculus]

Related Sequences to LMP006601 proteins

Reference Database Accession Length Protein Name
GI:226874881 DBBJ BAC66698.1 376 beta1,3-N-acetylglucosaminyltransferase [Mus musculus]
GI:226874881 GenBank AAK31579.1 376 beta1,3 N-acetyglucosaminyltransferase Lc3 synthase [Mus musculus]
GI:226874881 GenBank EDL77982.1 377 rCG36757 [Rattus norvegicus]
GI:226874881 RefSeq NP_446384.1 377 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase [Rattus norvegicus]
GI:226874881 RefSeq XP_008767071.1 377 PREDICTED: lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase isoform X1 [Rattus norvegicus]
GI:226874881 SwissProt Q99NB2.2 377 RecName: Full=Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; AltName: Full=Lactotriaosylceramide synthase; Short=Lc(3)Cer synthase; Short=Lc3 synthase; AltName: Full=UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5; Short=BGnT-5; Short=Beta-1,3-Gn-T5; Short=Beta-1,3-N-acetylglucosaminyltransferase 5; Short=Beta3Gn-T5 [Rattus norvegicus]