Gene/Proteome Database (LMPD)

LMPD ID
LMP006705
Gene ID
5320
Species
Homo sapiens (Human)
Gene Name
phospholipase A2, group IIA (platelets, synovial fluid)
Gene Symbol
PLA2G2A
Synonyms
MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2
Alternate Names
phospholipase A2, membrane associated; NPS-PLA2; GIIC sPLA2; group IIA phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A; non-pancreatic secretory phospholipase A2
Chromosome
1
Map Location
1p35
EC Number
3.1.1.4
Summary
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
Orthologs
View orthologs and multiple alignments for PLA2G2A

Proteins

phospholipase A2, membrane associated precursor
Refseq ID NP_001155199
Protein GI 239915985
UniProt ID P14555
mRNA ID NM_001161727
Length 144
RefSeq Status REVIEWED
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
phospholipase A2, membrane associated precursor
Refseq ID NP_000291
Protein GI 4505849
UniProt ID P14555
mRNA ID NM_000300
Length 144
RefSeq Status REVIEWED
Protein sequence is identical to GI:239915985 (mRNA isoform)
phospholipase A2, membrane associated precursor
Refseq ID NP_001155200
Protein GI 239915987
UniProt ID P14555
mRNA ID NM_001161728
Length 144
RefSeq Status REVIEWED
Protein sequence is identical to GI:239915985 (mRNA isoform)
phospholipase A2, membrane associated precursor
Refseq ID NP_001155201
Protein GI 239915991
UniProt ID P14555
mRNA ID NM_001161729
Length 144
RefSeq Status REVIEWED
Protein sequence is identical to GI:239915985 (mRNA isoform)
sig_peptide: 1..20 calculated_mol_wt: 2183 peptide sequence: MKTLLLLAVIMIFGLLQAHG mat_peptide: 21..144 product: phospholipase A2, membrane associated calculated_mol_wt: 13918 peptide sequence: NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC sig_peptide: 1..20 calculated_mol_wt: 2183 peptide sequence: MKTLLLLAVIMIFGLLQAHG mat_peptide: 21..144 product: phospholipase A2, membrane associated calculated_mol_wt: 13918 peptide sequence: NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC sig_peptide: 1..20 calculated_mol_wt: 2183 peptide sequence: MKTLLLLAVIMIFGLLQAHG mat_peptide: 21..144 product: phospholipase A2, membrane associated calculated_mol_wt: 13918 peptide sequence: NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC sig_peptide: 1..20 calculated_mol_wt: 2183 peptide sequence: MKTLLLLAVIMIFGLLQAHG mat_peptide: 21..144 product: phospholipase A2, membrane associated calculated_mol_wt: 13918 peptide sequence: NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC

Gene Information

Entrez Gene ID
5320
Gene Name
phospholipase A2, group IIA (platelets, synovial fluid)
Gene Symbol
PLA2G2A
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:LIFEdb C endoplasmic reticulum
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0005576 TAS:Reactome C extracellular region
GO:0005615 IDA:BHF-UCL C extracellular space
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0005739 IEA:Ensembl C mitochondrion
GO:0030141 IEA:Ensembl C secretory granule
GO:0005509 IEA:InterPro F calcium ion binding
GO:0047498 TAS:UniProtKB F calcium-dependent phospholipase A2 activity
GO:0004623 IDA:BHF-UCL F phospholipase A2 activity
GO:0005543 IDA:BHF-UCL F phospholipid binding
GO:0050830 TAS:BHF-UCL P defense response to Gram-positive bacterium
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0034374 TAS:BHF-UCL P low-density lipoprotein particle remodeling
GO:0050680 IEA:Ensembl P negative regulation of epithelial cell proliferation
GO:0006654 TAS:Reactome P phosphatidic acid biosynthetic process
GO:0046473 IDA:BHF-UCL P phosphatidic acid metabolic process
GO:0036151 TAS:Reactome P phosphatidylcholine acyl-chain remodeling
GO:0036152 TAS:Reactome P phosphatidylethanolamine acyl-chain remodeling
GO:0036148 TAS:Reactome P phosphatidylglycerol acyl-chain remodeling
GO:0036149 TAS:Reactome P phosphatidylinositol acyl-chain remodeling
GO:0036150 TAS:Reactome P phosphatidylserine acyl-chain remodeling
GO:0006644 IDA:BHF-UCL P phospholipid metabolic process
GO:0050729 TAS:BHF-UCL P positive regulation of inflammatory response
GO:0010744 TAS:BHF-UCL P positive regulation of macrophage derived foam cell differentiation
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0035019 IEA:Ensembl P somatic stem cell maintenance

KEGG Pathway Links

KEGG Pathway ID Description
hsa04014 Ras signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR001211 Phospholipase A2
IPR016090 Phospholipase A2 domain
IPR013090 Phospholipase A2, active site

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group IIA (platelets, synovial fluid)
Protein Entry
PA2GA_HUMAN
UniProt ID
P14555
Species
Human

Comments

Comment Type Description
Catalytic Activity Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO
Cofactor Name=Ca(2+); Xref=ChEBI
Function Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides.
Miscellaneous Group II phospholipase A2 is found in many cells and also extracellularly. The membrane-bound and secreted forms are identical and are encoded by a single gene.
Similarity Belongs to the phospholipase A2 family.
Subcellular Location Membrane; Peripheral membrane protein.
Web Resource Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PLA2G2AID41730ch1p36.html";
Web Resource Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pla2g2a/";

Identical and Related Proteins

Unique RefSeq proteins for LMP006705 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
239915985 RefSeq NP_001155199 144 phospholipase A2, membrane associated precursor

Identical Sequences to LMP006705 proteins

Reference Database Accession Length Protein Name
GI:239915985 GenBank ADR86966.1 144 Sequence 106 from patent US 7740664
GI:239915985 GenBank AED80966.1 144 Sequence 3 from patent US 7919458
GI:239915985 GenBank AEU43257.1 144 Sequence 6 from patent US 8052970
GI:239915985 GenBank AEU43309.1 144 Sequence 58 from patent US 8052970
GI:239915985 GenBank AGF22437.1 144 Sequence 2 from patent US 8372594
GI:239915985 GenBank AHD77304.1 144 Sequence 22437 from patent US 8586006

Related Sequences to LMP006705 proteins

Reference Database Accession Length Protein Name
GI:239915985 GenBank AAT73043.1 144 platelet phospholipase A2 [Homo sapiens]
GI:239915985 GenBank AAT73044.1 144 platelet phospholipase A2 [Homo sapiens]
GI:239915985 GenBank ACM83019.1 164 Sequence 8517 from patent US 6812339
GI:239915985 RefSeq XP_001160344.1 144 PREDICTED: phospholipase A2, membrane associated [Pan troglodytes]
GI:239915985 RefSeq XP_001160395.1 144 PREDICTED: phospholipase A2, membrane associated [Pan troglodytes]
GI:239915985 RefSeq XP_001160501.1 144 PREDICTED: phospholipase A2, membrane associated [Pan troglodytes]