Gene/Proteome Database (LMPD)

LMPD ID
LMP006761
Gene ID
161357
Species
Homo sapiens (Human)
Gene Name
MAM domain containing glycosylphosphatidylinositol anchor 2
Gene Symbol
MDGA2
Synonyms
MAMDC1; c14_5286
Alternate Names
MAM domain-containing glycosylphosphatidylinositol anchor protein 2; MAM domain containing 1
Chromosome
14
Map Location
14q21.3

Proteins

MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform 1 precursor
Refseq ID NP_001106970
Protein GI 514961956
UniProt ID Q7Z553
mRNA ID NM_001113498
Length 956
RefSeq Status VALIDATED
MDLLYGLVWLLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATKNSVDGAVGILVHIWLFPIIVLISILSPRR
MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform 2
Refseq ID NP_878250
Protein GI 38158013
UniProt ID Q7Z553
mRNA ID NM_182830
Length 727
RefSeq Status VALIDATED
MVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATKNSVDGAVGILVHIWLFPIIVLISILSPRR
sig_peptide: 1..25 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q7Z553.2) calculated_mol_wt: 2724 peptide sequence: MDLLYGLVWLLTVLLEGISGQGVYA mat_peptide: 26..931 product: MAM domain-containing glycosylphosphatidylinositol anchor protein 2 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q7Z553.2) calculated_mol_wt: 101965 peptide sequence: PPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATKNSVD

Gene Information

Entrez Gene ID
161357
Gene Name
MAM domain containing glycosylphosphatidylinositol anchor 2
Gene Symbol
MDGA2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031225 IEA:UniProtKB-KW C anchored component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0007389 IEA:Ensembl P pattern specification process
GO:0021522 ISS:HGNC P spinal cord motor neuron differentiation

Domain Information

InterPro Annotations

Accession Description
IPR013320 Concanavalin A-like lectin/glucanase domain
IPR003961 Fibronectin type III
IPR013098 Immunoglobulin I-set
IPR003599 Immunoglobulin subtype
IPR003598 Immunoglobulin subtype 2
IPR007110 Immunoglobulin-like domain
IPR013783 Immunoglobulin-like fold
IPR000998 MAM domain

UniProt Annotations

Entry Information

Gene Name
MAM domain containing glycosylphosphatidylinositol anchor 2
Protein Entry
MDGA2_HUMAN
UniProt ID
Q7Z553
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7Z553-1; Sequence=Displayed; Name=2; IsoId=Q7Z553-2; Sequence=VSP_042468; Name=3; IsoId=Q7Z553-3; Sequence=VSP_045240; Note=No experimental confirmation available. Ref.2 (AK309211) sequence is in conflict in position: 50:G->S. ;
Function May be involved in cell-cell interactions.
Sequence Caution Sequence=AAP97010.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Similarity Contains 1 MAM domain. {ECO
Similarity Contains 1 fibronectin type-III domain.
Similarity Contains 6 Ig-like (immunoglobulin-like) domains.
Subcellular Location Cell membrane ; Lipid-anchor, GPI-anchor .
Subunit Interacts (through the Ig-like domains) with NLGN2.
Tissue Specificity Detected in Leydig cells, syncytiotrophoblast, duodenal villi epithelial cells and neutrophils from kidney and cutaneous squamous cell carcinoma (at protein level).

Identical and Related Proteins

Unique RefSeq proteins for LMP006761 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
514961956 RefSeq NP_001106970 956 MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform 1 precursor
38158013 RefSeq NP_878250 727 MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform 2

Identical Sequences to LMP006761 proteins

Reference Database Accession Length Protein Name
GI:514961956 GenBank AAQ73312.1 956 MAM domain-containing glycosylphosphatidylinositol anchor 2 [Homo sapiens]
GI:38158013 GenBank AAI60160.1 727 MAM domain containing glycosylphosphatidylinositol anchor 2 [synthetic construct]
GI:38158013 GenBank AHD77655.1 727 Sequence 23784 from patent US 8586006
GI:514961956 SwissProt Q7Z553.2 956 RecName: Full=MAM domain-containing glycosylphosphatidylinositol anchor protein 2; AltName: Full=MAM domain-containing protein 1; Flags: Precursor [Homo sapiens]

Related Sequences to LMP006761 proteins

Reference Database Accession Length Protein Name
GI:38158013 GenBank AAQ73312.1 956 MAM domain-containing glycosylphosphatidylinositol anchor 2 [Homo sapiens]
GI:38158013 GenBank AAQ88492.1 937 MAM-domain protein, partial [Homo sapiens]
GI:514961956 RefSeq XP_001097544.1 1025 PREDICTED: MAM domain-containing glycosylphosphatidylinositol anchor protein 2-like isoform 4 [Macaca mulatta]
GI:514961956 RefSeq XP_001151973.1 1025 PREDICTED: MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform X1 [Pan troglodytes]
GI:514961956 RefSeq XP_003831798.1 1025 PREDICTED: MAM domain-containing glycosylphosphatidylinositol anchor protein 2 [Pan paniscus]
GI:514961956 RefSeq XP_003930606.1 1025 PREDICTED: MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform X1 [Saimiri boliviensis boliviensis]
GI:38158013 RefSeq NP_001106970.3 956 MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform 1 precursor [Homo sapiens]
GI:514961956 RefSeq XP_005561242.1 1025 PREDICTED: MAM domain-containing glycosylphosphatidylinositol anchor protein 2 [Macaca fascicularis]
GI:38158013 RefSeq XP_005561242.1 1025 PREDICTED: MAM domain-containing glycosylphosphatidylinositol anchor protein 2 [Macaca fascicularis]
GI:38158013 RefSeq XP_006720131.1 957 PREDICTED: MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform X1 [Homo sapiens]
GI:514961956 RefSeq XP_007984795.1 1025 PREDICTED: MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform X1 [Chlorocebus sabaeus]
GI:38158013 SwissProt Q7Z553.2 956 RecName: Full=MAM domain-containing glycosylphosphatidylinositol anchor protein 2; AltName: Full=MAM domain-containing protein 1; Flags: Precursor [Homo sapiens]