Gene/Proteome Database (LMPD)
LMPD ID
LMP006769
Gene ID
Species
Homo sapiens (Human)
Gene Name
arylsulfatase D
Gene Symbol
Synonyms
ASD
Alternate Names
arylsulfatase D
Chromosome
X
Map Location
Xp22.3
EC Number
3.1.6.-
Summary
The protein encoded by this gene is a member of the sulfatase family. Sulfatases are essential for the correct composition of bone and cartilage matrix. The encoded protein is postranslationally glycosylated and localized to the lysosome. This gene is located within a cluster of similar arylsulfatase genes on chromosome X. A related pseudogene has been identified in the pseudoautosomal region of chromosome Y. [provided by RefSeq, Jul 2011]
Orthologs
Proteins
| arylsulfatase D precursor | |
|---|---|
| Refseq ID | NP_001660 |
| Protein GI | 71852584 |
| UniProt ID | P51689 |
| mRNA ID | NM_001669 |
| Length | 593 |
| RefSeq Status | REVIEWED |
| MRSAARRGRAAPAARDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTLTNDCDPGRPPEVDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLFFISWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQKDSGSVWKVHYTTPQFHPEGAGACYGRGVCPCSGEGVTHHRPPLLFDLSRDPSEARPLTPDSEPLYHAVIARVGAAVSEHRQTLSPVPQQFSMSNILWKPWLQPCCGHFPFCSCHEDGDGTP | |
| sig_peptide: 1..33 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (P51689.2) calculated_mol_wt: 3597 peptide sequence: MRSAARRGRAAPAARDSLPVLLFLCLLLKTCEP mat_peptide: 34..593 product: Arylsulfatase D experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P51689.2) calculated_mol_wt: 61281 peptide sequence: KTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTLTNDCDPGRPPEVDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLFFISWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQKDSGSVWKVHYTTPQFHPEGAGACYGRGVCPCSGEGVTHHRPPLLFDLSRDPSEARPLTPDSEPLYHAVIARVGAAVSEHRQTLSPVPQQFSMSNILWKPWLQPCCGHFPFCSCHEDGDGTP | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005788 | TAS:Reactome | C | endoplasmic reticulum lumen |
| GO:0070062 | IDA:UniProt | C | extracellular vesicular exosome |
| GO:0005764 | IEA:UniProtKB-KW | C | lysosome |
| GO:0004065 | TAS:ProtInc | F | arylsulfatase activity |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0044267 | TAS:Reactome | P | cellular protein metabolic process |
| GO:0006687 | TAS:Reactome | P | glycosphingolipid metabolic process |
| GO:0043687 | TAS:Reactome | P | post-translational protein modification |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0006665 | TAS:Reactome | P | sphingolipid metabolic process |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_116105 | Glycosphingolipid metabolism |
| REACT_19323 | Sphingolipid metabolism |
| REACT_121036 | The activation of arylsulfatases |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P51689-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=P51689-2; Sequence=VSP_015798, VSP_015799; Name=3; Synonyms=Alpha; IsoId=P51689-3; Sequence=VSP_035667; |
| Cofactor | Name=Ca(2+); Xref=ChEBI |
| Ptm | The conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. |
| Sequence Caution | Sequence=CAA58555.1; Type=Frameshift; Positions=Several; Evidence= ; |
| Similarity | Belongs to the sulfatase family. |
| Subcellular Location | Lysosome . |
| Tissue Specificity | Expressed in the pancreas, kidney, liver, lung, placenta, brain and heart. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006769 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 71852584 | RefSeq | NP_001660 | 593 | arylsulfatase D precursor |
Identical Sequences to LMP006769 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:71852584 | GenBank | AHD75035.1 | 593 | Sequence 16314 from patent US 8586006 |
| GI:71852584 | SwissProt | P51689.2 | 593 | RecName: Full=Arylsulfatase D; Short=ASD; Flags: Precursor [Homo sapiens] |
Related Sequences to LMP006769 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:71852584 | DBBJ | BAJ21123.1 | 593 | arylsulfatase D, partial [synthetic construct] |
| GI:71852584 | GenBank | AAX36100.1 | 594 | arylsulfatase D, partial [synthetic construct] |
| GI:71852584 | GenBank | EAW98716.1 | 593 | arylsulfatase D, isoform CRA_d [Homo sapiens] |
| GI:71852584 | GenBank | ACM97185.1 | 593 | Sequence 77 from patent US 7473531 |
| GI:71852584 | GenBank | AFQ69838.1 | 593 | Sequence 21 from patent US 8227212 |
| GI:71852584 | RefSeq | XP_003814442.2 | 660 | PREDICTED: arylsulfatase D [Pan paniscus] |