Gene/Proteome Database (LMPD)

LMPD ID
LMP006770
Gene ID
85450
Species
Homo sapiens (Human)
Gene Name
inositol 1,4,5-trisphosphate receptor interacting protein
Gene Symbol
ITPRIP
Synonyms
DANGER; KIAA1754; bA127L20; bA127L20.2
Alternate Names
inositol 1,4,5-trisphosphate receptor-interacting protein; inositol 1,4,5-triphosphate receptor-interacting protein
Chromosome
10
Map Location
10q25.1
Summary
This gene encodes a membrane-associated protein that binds the inositol 1,4,5-trisphosphate receptor (ITPR). The encoded protein enhances the sensitivity of ITPR to intracellular calcium signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Orthologs
View orthologs and multiple alignments for ITPRIP

Proteins

inositol 1,4,5-trisphosphate receptor-interacting protein precursor
Refseq ID NP_203755
Protein GI 29789287
UniProt ID Q8IWB1
mRNA ID NM_033397
Length 547
RefSeq Status REVIEWED
MAMGLFRVCLVVVTAIINHPLLFPRENATVPENEEEIIRKMQAHQEKLQLEQLRLEEEVARLAAEKEALEQVAEEGRQQNETRVAWDLWSTLCMILFLMIEVWRQDHQEGPSPECLGGEEDELPGLGGAPLQGLTLPNKATLGHFYERCIRGATADAARTREFLEGFVDDLLEALRSLCNRDTDMEVEDFIGVDSMYENWQVDRPLLCHLFVPFTPPEPYRFHPELWCSGRSVPLDRQGYGQIKVVRADGDTLSCICGKTKLGEDMLCLLHGRNSMAPPCGDMENLLCATDSLYLDTMQVMKWFQTALTRAWKGIAHKYEFDLAFGQLDSPGSLKIKFRSGKFMPFNLIPVIQCDDSDLYFVSHLPREPSEGTPASSTDWLLSFAVYERHFLRTTLKALPEGACHLSCLQIASFLLSKQSRLTGPSGLSSYHLKTALLHLLLLRQAADWKAGQLDARLHELLCFLEKSLLQKKLHHFFIGNRKVPEAMGLPEAVLRAEPLNLFRPFVLQRSLYRKTLDSFYEMLKNAPALISEYSLHVPSDQPTPKS
sig_peptide: 1..15 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1610 peptide sequence: MAMGLFRVCLVVVTA mat_peptide: 16..547 product: Inositol 1,4,5-trisphosphate receptor-interacting protein experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8IWB1.1) calculated_mol_wt: 60468 peptide sequence: IINHPLLFPRENATVPENEEEIIRKMQAHQEKLQLEQLRLEEEVARLAAEKEALEQVAEEGRQQNETRVAWDLWSTLCMILFLMIEVWRQDHQEGPSPECLGGEEDELPGLGGAPLQGLTLPNKATLGHFYERCIRGATADAARTREFLEGFVDDLLEALRSLCNRDTDMEVEDFIGVDSMYENWQVDRPLLCHLFVPFTPPEPYRFHPELWCSGRSVPLDRQGYGQIKVVRADGDTLSCICGKTKLGEDMLCLLHGRNSMAPPCGDMENLLCATDSLYLDTMQVMKWFQTALTRAWKGIAHKYEFDLAFGQLDSPGSLKIKFRSGKFMPFNLIPVIQCDDSDLYFVSHLPREPSEGTPASSTDWLLSFAVYERHFLRTTLKALPEGACHLSCLQIASFLLSKQSRLTGPSGLSSYHLKTALLHLLLLRQAADWKAGQLDARLHELLCFLEKSLLQKKLHHFFIGNRKVPEAMGLPEAVLRAEPLNLFRPFVLQRSLYRKTLDSFYEMLKNAPALISEYSLHVPSDQPTPKS sig_peptide: 1..15 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1610 peptide sequence: MAMGLFRVCLVVVTA mat_peptide: 16..547 product: Inositol 1,4,5-trisphosphate receptor-interacting protein experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8IWB1.1) calculated_mol_wt: 60468 peptide sequence: IINHPLLFPRENATVPENEEEIIRKMQAHQEKLQLEQLRLEEEVARLAAEKEALEQVAEEGRQQNETRVAWDLWSTLCMILFLMIEVWRQDHQEGPSPECLGGEEDELPGLGGAPLQGLTLPNKATLGHFYERCIRGATADAARTREFLEGFVDDLLEALRSLCNRDTDMEVEDFIGVDSMYENWQVDRPLLCHLFVPFTPPEPYRFHPELWCSGRSVPLDRQGYGQIKVVRADGDTLSCICGKTKLGEDMLCLLHGRNSMAPPCGDMENLLCATDSLYLDTMQVMKWFQTALTRAWKGIAHKYEFDLAFGQLDSPGSLKIKFRSGKFMPFNLIPVIQCDDSDLYFVSHLPREPSEGTPASSTDWLLSFAVYERHFLRTTLKALPEGACHLSCLQIASFLLSKQSRLTGPSGLSSYHLKTALLHLLLLRQAADWKAGQLDARLHELLCFLEKSLLQKKLHHFFIGNRKVPEAMGLPEAVLRAEPLNLFRPFVLQRSLYRKTLDSFYEMLKNAPALISEYSLHVPSDQPTPKS sig_peptide: 1..15 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1610 peptide sequence: MAMGLFRVCLVVVTA mat_peptide: 16..547 product: Inositol 1,4,5-trisphosphate receptor-interacting protein experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8IWB1.1) calculated_mol_wt: 60468 peptide sequence: IINHPLLFPRENATVPENEEEIIRKMQAHQEKLQLEQLRLEEEVARLAAEKEALEQVAEEGRQQNETRVAWDLWSTLCMILFLMIEVWRQDHQEGPSPECLGGEEDELPGLGGAPLQGLTLPNKATLGHFYERCIRGATADAARTREFLEGFVDDLLEALRSLCNRDTDMEVEDFIGVDSMYENWQVDRPLLCHLFVPFTPPEPYRFHPELWCSGRSVPLDRQGYGQIKVVRADGDTLSCICGKTKLGEDMLCLLHGRNSMAPPCGDMENLLCATDSLYLDTMQVMKWFQTALTRAWKGIAHKYEFDLAFGQLDSPGSLKIKFRSGKFMPFNLIPVIQCDDSDLYFVSHLPREPSEGTPASSTDWLLSFAVYERHFLRTTLKALPEGACHLSCLQIASFLLSKQSRLTGPSGLSSYHLKTALLHLLLLRQAADWKAGQLDARLHELLCFLEKSLLQKKLHHFFIGNRKVPEAMGLPEAVLRAEPLNLFRPFVLQRSLYRKTLDSFYEMLKNAPALISEYSLHVPSDQPTPKS
inositol 1,4,5-trisphosphate receptor-interacting protein precursor
Refseq ID NP_001258941
Protein GI 436408724
UniProt ID Q8IWB1
mRNA ID NM_001272012
Length 547
RefSeq Status REVIEWED
Protein sequence is identical to GI:29789287 (mRNA isoform)
inositol 1,4,5-trisphosphate receptor-interacting protein precursor
Refseq ID NP_001258942
Protein GI 436408726
UniProt ID Q8IWB1
mRNA ID NM_001272013
Length 547
RefSeq Status REVIEWED
Protein sequence is identical to GI:29789287 (mRNA isoform)

Gene Information

Entrez Gene ID
85450
Gene Name
inositol 1,4,5-trisphosphate receptor interacting protein
Gene Symbol
ITPRIP
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016020 IDA:UniProtKB C membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR024797 Inositol 1,4,5-trisphosphate receptor-interacting protein
IPR026250 Inositol 1,4,5-trisphosphate receptor-interacting protein family
IPR024810 Mab-21 domain

UniProt Annotations

Entry Information

Gene Name
inositol 1,4,5-trisphosphate receptor interacting protein
Protein Entry
IPRI_HUMAN
UniProt ID
Q8IWB1
Species
Human

Comments

Comment Type Description
Function Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release.
Sequence Caution Sequence=BAB21845.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the ITPRIP family.
Subcellular Location Cell membrane .
Subunit Interacts with ITPR.
Tissue Specificity Detected in brain where it is concentrated in cerebellar Purkinje cells (at protein level).

Identical and Related Proteins

Unique RefSeq proteins for LMP006770 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
29789287 RefSeq NP_203755 547 inositol 1,4,5-trisphosphate receptor-interacting protein precursor

Identical Sequences to LMP006770 proteins

Reference Database Accession Length Protein Name
GI:29789287 EMBL CBX47550.1 547 unnamed protein product [Homo sapiens]
GI:29789287 GenBank ADT47125.1 547 Sequence 786 from patent US 7842466
GI:29789287 GenBank ADT47126.1 547 Sequence 787 from patent US 7842466
GI:29789287 GenBank AHL57864.1 547 Sequence 260 from patent US 8647822
GI:29789287 RefSeq NP_001258941.1 547 inositol 1,4,5-trisphosphate receptor-interacting protein precursor [Homo sapiens]
GI:29789287 RefSeq NP_001258942.1 547 inositol 1,4,5-trisphosphate receptor-interacting protein precursor [Homo sapiens]

Related Sequences to LMP006770 proteins

Reference Database Accession Length Protein Name
GI:29789287 DBBJ BAB21845.1 594 KIAA1754 protein, partial [Homo sapiens]
GI:29789287 GenBank JAA02921.1 547 inositol 1,4,5-trisphosphate receptor interacting protein [Pan troglodytes]
GI:29789287 GenBank JAA16621.1 547 inositol 1,4,5-trisphosphate receptor interacting protein [Pan troglodytes]
GI:29789287 GenBank JAA39321.1 547 inositol 1,4,5-trisphosphate receptor interacting protein [Pan troglodytes]
GI:29789287 RefSeq XP_508022.3 547 PREDICTED: inositol 1,4,5-trisphosphate receptor-interacting protein isoform X2 [Pan troglodytes]
GI:29789287 RefSeq XP_005270314.1 552 PREDICTED: inositol 1,4,5-trisphosphate receptor-interacting protein isoform X1 [Homo sapiens]