Gene/Proteome Database (LMPD)
LMPD ID
LMP006798
Gene ID
Species
Homo sapiens (Human)
Gene Name
MAM domain containing glycosylphosphatidylinositol anchor 1
Gene Symbol
Synonyms
GPIM; MAMDC3
Alternate Names
MAM domain-containing glycosylphosphatidylinositol anchor protein 1; GPI and MAM protein; MAM domain-containing protein 3; glycosylphosphatidylinositol-MAM; glycosyl-phosphatidyl-inositol-MAM
Chromosome
6
Map Location
6p21
Proteins
| MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor | |
|---|---|
| Refseq ID | NP_705691 |
| Protein GI | 24111244 |
| UniProt ID | Q8NFP4 |
| mRNA ID | NM_153487 |
| Length | 955 |
| RefSeq Status | VALIDATED |
| MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRKQTDPNKVVVMPGSGAPCQSSPQLWGPMAIFLLALQR | |
| sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2030 peptide sequence: MEVTCLLLLALIPFHCRG mat_peptide: 19..932 product: MAM domain-containing glycosylphosphatidylinositol anchor protein 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8NFP4.1) calculated_mol_wt: 101312 peptide sequence: QGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRKQTDPNKVVVMPGS | |
Gene Information
Entrez Gene ID
Gene Name
MAM domain containing glycosylphosphatidylinositol anchor 1
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0046658 | IDA:UniProtKB | C | anchored component of plasma membrane |
| GO:0005615 | IDA:UniProt | C | extracellular space |
| GO:0007420 | ISS:HGNC | P | brain development |
| GO:0021799 | IEA:Ensembl | P | cerebral cortex radially oriented cell migration |
| GO:0001764 | ISS:UniProtKB | P | neuron migration |
| GO:0021527 | ISS:HGNC | P | spinal cord association neuron differentiation |
Domain Information
InterPro Annotations
UniProt Annotations
Entry Information
Gene Name
MAM domain containing glycosylphosphatidylinositol anchor 1
Protein Entry
MDGA1_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NFP4-1; Sequence=Displayed; Name=2; IsoId=Q8NFP4-2; Sequence=VSP_009835; Note=No experimental confirmation available.; |
| Function | Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2. {ECO |
| Sequence Caution | Sequence=BAC03502.1; Type=Erroneous initiation; Evidence= ; |
| Similarity | Contains 1 MAM domain. {ECO |
| Similarity | Contains 1 fibronectin type-III domain. |
| Similarity | Contains 6 Ig-like (immunoglobulin-like) domains. |
| Subcellular Location | Cell membrane ; Lipid-anchor, GPI-anchor . Note=Associated with lipid rafts. |
| Subunit | Interacts heterophilically through its MAM domain with proteins in axon-rich regions and through its Ig-like domains with proteins in differentiating muscle (By similarity). Interacts (through the Ig-like domains) with NLGN2. {ECO |
| Tissue Specificity | Has been found in brain, heart, skeletal muscle and kidney. Found to be overexpressed in tumor tissues. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006798 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 24111244 | RefSeq | NP_705691 | 955 | MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor |
Identical Sequences to LMP006798 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:24111244 | DBBJ | BAI45551.1 | 955 | MAM domain containing glycosylphosphatidylinositol anchor 1, partial [synthetic construct] |
| GI:24111244 | GenBank | EAX03952.1 | 955 | MAM domain containing glycosylphosphatidylinositol anchor 1, isoform CRA_c [Homo sapiens] |
| GI:24111244 | GenBank | AAI52818.1 | 955 | MAM domain containing glycosylphosphatidylinositol anchor 1, partial [synthetic construct] |
| GI:24111244 | GenBank | AAI56660.1 | 955 | MAM domain containing glycosylphosphatidylinositol anchor 1 [synthetic construct] |
| GI:24111244 | GenBank | JAA08623.1 | 955 | MAM domain containing glycosylphosphatidylinositol anchor 1 [Pan troglodytes] |
| GI:24111244 | GenBank | JAA24043.1 | 955 | MAM domain containing glycosylphosphatidylinositol anchor 1 [Pan troglodytes] |
Related Sequences to LMP006798 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:24111244 | GenBank | JAA15793.1 | 955 | MAM domain containing glycosylphosphatidylinositol anchor 1 [Pan troglodytes] |
| GI:24111244 | RefSeq | XP_527378.2 | 955 | PREDICTED: MAM domain-containing glycosylphosphatidylinositol anchor protein 1 isoform X5 [Pan troglodytes] |
| GI:24111244 | RefSeq | XP_004043996.1 | 955 | PREDICTED: MAM domain-containing glycosylphosphatidylinositol anchor protein 1 [Gorilla gorilla gorilla] |
| GI:24111244 | RefSeq | XP_005553176.1 | 955 | PREDICTED: MAM domain-containing glycosylphosphatidylinositol anchor protein 1 isoform X2 [Macaca fascicularis] |
| GI:24111244 | RefSeq | XP_007970931.1 | 955 | PREDICTED: MAM domain-containing glycosylphosphatidylinositol anchor protein 1 isoform X2 [Chlorocebus sabaeus] |
| GI:24111244 | RefSeq | XP_010388018.1 | 955 | PREDICTED: MAM domain-containing glycosylphosphatidylinositol anchor protein 1 [Rhinopithecus roxellana] |