LIPID MAPS

LMPD ID

LMP006818

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

acyl-CoA oxidase

Gene Symbol

POX1

Synonyms

FOX1

Chromosome

VII

EC Number

1.3.3.6;

acyl-CoA oxidase
Refseq ID	NP_011310
Protein GI	6321233
UniProt ID	P13711
mRNA ID	NM_001181070
Length	748
MTRRTTINPDSVVLNPQKFIQKERADSKIKVDQVNTFLESSPERRTLTHALIDQIVNDPILKTDTDYYDAKKMQEREITAKKIARLASYMEHDIKTVRKHFRDTDLMKELQANDPDKASPLTNKDLFIFDKRLSLVANIDPQLGTRVGVHLGLFGNCIKGNGTDEQIRYWLQERGATLMKGIYGCFAMTELGHGSNVAQLQTRAVYDKQNDTFVIDTPDLTATKWWIGGAAHSATHAAVYARLIVEGKDYGVKTFVVPLRDPSTFQLLAGVSIGDIGAKMGRDGIDNGWIQFRNVVIPREFMLSRFTKVVRSPDGSVTVKTEPQLDQISGYSALLSGRVNMVMDSFRFGSKFATIAVRYAVGRQQFAPRKGLSETQLIDYPLHQYRVLPQLCVPYLVSPVAFKLMDNYYSTLDELYNASSSAYKAALVTVSKKLKNLFIDSASLKATNTWLIATLIDELRQTCGGHGYSQYNGFGKGYDDWVVQCTWEGDNNVLSLTSAKSILKKFIDSATKGRFDNTLDVDSFSYLKPQYIGSVVSGEIKSGLKELGDYTEIWSITLIKLLAHIGTLVEKSRSIDSVSKLLVLVSKFHALRCMLKTYYDKLNSRDSHISDEITKESMWNVYKLFSLYFIDKHSGEFQQFKIFTPDQISKVVQPQLLALLPIVRKDCIGLTDSFELPDAMLNSPIGYFDGDIYHNYFNEVCRNNPVEADGAGKPSYHALLSSMLGRGFEFDQKLGGAANAEILSKINK

Entrez Gene ID

Gene Name

acyl-CoA oxidase

Gene Symbol

POX1

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005782	IDA:SGD	C	peroxisomal matrix
GO:0003995	IEA:InterPro	F	acyl-CoA dehydrogenase activity
GO:0003997	ISA:SGD	F	acyl-CoA oxidase activity
GO:0050660	IEA:InterPro	F	flavin adenine dinucleotide binding
GO:0006635	IMP:SGD	P	fatty acid beta-oxidation
GO:0033540	ISA:SGD	P	fatty acid beta-oxidation using acyl-CoA oxidase

KEGG Pathway ID	Description
ko01040	Biosynthesis of unsaturated fatty acids
sce01040	Biosynthesis of unsaturated fatty acids
ko00071	Fatty acid degradation
sce00071	Fatty acid degradation
ko01212	Fatty acid metabolism
sce01212	Fatty acid metabolism
sce01100	Metabolic pathways
ko04146	Peroxisome
sce04146	Peroxisome
ko00592	alpha-Linolenic acid metabolism
sce00592	alpha-Linolenic acid metabolism

BIOCYC Pathway ID	Description
PWY-7337	10-cis-heptadecenoyl-CoA degradation
PWY-7337	10-cis-heptadecenoyl-CoA degradation (yeast)
PWY-7338	10-trans-heptadecenoyl-CoA degradation (reductase-dependent)
PWY-7338	10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)
PWY-6920	6-gingerol analog biosynthesis
PWY-7340	9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent)
PWY-7340	9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)
PWY-7288	fatty acid beta-oxidation (peroxisome)
PWY-7288	fatty acid beta-oxidation (peroxisome, yeast)
PWY-6837	fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)
YEAST-FAO-PWY	fatty acid oxidation (non-cyclic)
PWY-7291	oleate beta-oxidation (isomerase-dependent)
PWY-7291	oleate beta-oxidation (isomerase-dependent, yeast)

REACTOME Pathway ID	Description
5618477	Beta-oxidation of pristanoyl-CoA
5618483	Beta-oxidation of very long chain fatty acids
5618352	Bile acid and bile salt metabolism
5618090	Fatty acid, triacylglycerol, and ketone body metabolism
5618023	Metabolism
5618091	Metabolism of lipids and lipoproteins
5618608	PPARA activates gene expression
5618473	Peroxisomal lipid metabolism
5618609	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5618351	Synthesis of bile acids and bile salts
5618353	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
5618631	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
5618632	alpha-linolenic acid (ALA) metabolism

Accession	Description
IPR009075	Acyl-CoA dehydrogenase/oxidase C-terminal
IPR013786	Acyl-CoA dehydrogenase/oxidase, N-terminal
IPR009100	Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR012258	Acyl-CoA oxidase
IPR002655	Acyl-CoA oxidase, C-terminal
IPR006091	Acyl-CoA oxidase/dehydrogenase, central domain
IPR029320	Acyl-coenzyme A oxidase, N-terminal

Gene Name

acyl-CoA oxidase

Protein Entry

ACOX_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2).
Cofactor	Name=FAD; Xref=ChEBI:CHEBI:57692;
Interaction	P40016:RPN3; NbExp=1; IntAct=EBI-3999, EBI-15927; P23255:TAF2; NbExp=1; IntAct=EBI-3999, EBI-18862; P38800:YHR080C; NbExp=1; IntAct=EBI-3999, EBI-24597;
Pathway	Lipid metabolism; peroxisomal fatty acid beta-oxidation.
Similarity	Belongs to the acyl-CoA oxidase family
Similarity	Belongs to the acyl-CoA oxidase family. {ECO:0000305}.
Subcellular Location	Peroxisome.
Subunit	Homooctamer.