Gene/Proteome Database (LMPD)
Proteins
| branched-chain-amino-acid transaminase BAT1 | |
|---|---|
| Refseq ID | NP_012078 |
| Protein GI | 398365103 |
| UniProt ID | P38891 |
| mRNA ID | NM_001179339 |
| Length | 393 |
| MLQRHSLKLGKFSIRTLATGAPLDASKLKITRNPNPSKPRPNEELVFGQTFTDHMLTIPWSAKEGWGTPHIKPYGNLSLDPSACVFHYAFELFEGLKAYRTPQNTITMFRPDKNMARMNKSAARICLPTFESEELIKLTGKLIEQDKHLVPQGNGYSLYIRPTMIGTSKGLGVGTPSEALLYVITSPVGPYYKTGFKAVRLEATDYATRAWPGGVGDKKLGANYAPCILPQLQAAKRGYQQNLWLFGPEKNITEVGTMNVFFVFLNKVTGKKELVTAPLDGTILEGVTRDSVLTLARDKLDPQEWDINERYYTITEVATRAKQGELLEAFGSGTAAVVSPIKEIGWNNEDIHVPLLPGEQCGALTKQVAQWIADIQYGRVNYGNWSKTVADLN | |
Gene Information
Entrez Gene ID
Gene Name
branched-chain-amino-acid transaminase BAT1
Gene Symbol
Species
Saccharomyces cerevisiae S288c
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005759 | IDA:SGD | C | mitochondrial matrix |
| GO:0052656 | IEA:UniProtKB-EC | F | L-isoleucine transaminase activity |
| GO:0052654 | IEA:UniProtKB-EC | F | L-leucine transaminase activity |
| GO:0052655 | IEA:UniProtKB-EC | F | L-valine transaminase activity |
| GO:0004084 | IDA:SGD | F | branched-chain-amino-acid transaminase activity |
| GO:0019509 | IEA:UniProtKB-UniPathway | P | L-methionine biosynthetic process from methylthioadenosine |
| GO:0009082 | IDA:SGD | P | branched-chain amino acid biosynthetic process |
| GO:0009083 | IMP:SGD | P | branched-chain amino acid catabolic process |
| GO:0034644 | IMP:MGI | P | cellular response to UV |
| GO:0009097 | IEA:UniProtKB-UniPathway | P | isoleucine biosynthetic process |
| GO:0009098 | IEA:UniProtKB-UniPathway | P | leucine biosynthetic process |
| GO:0031571 | IMP:MGI | P | mitotic G1 DNA damage checkpoint |
| GO:0009099 | IEA:UniProtKB-UniPathway | P | valine biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko01210 | 2-Oxocarboxylic acid metabolism |
| sce01210 | 2-Oxocarboxylic acid metabolism |
| ko01230 | Biosynthesis of amino acids |
| sce01230 | Biosynthesis of amino acids |
| sce01110 | Biosynthesis of secondary metabolites |
| M00570 | Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine |
| sce_M00570 | Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine |
| sce01100 | Metabolic pathways |
| ko00770 | Pantothenate and CoA biosynthesis |
| sce00770 | Pantothenate and CoA biosynthesis |
| ko00290 | Valine, leucine and isoleucine biosynthesis |
| sce00290 | Valine, leucine and isoleucine biosynthesis |
| ko00280 | Valine, leucine and isoleucine degradation |
| sce00280 | Valine, leucine and isoleucine degradation |
| M00019 | Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine |
| sce_M00019 | Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| ILEUSYN-PWY | isoleucine biosynthesis |
| PWY3O-4109 | isoleucine degradation |
| PWY-5078 | isoleucine degradation II |
| PWY-5078 | isoleucine degradation II |
| LEUSYN-PWY | leucine biosynthesis |
| PWY3O-4112 | leucine degradation |
| PWY-5076 | leucine degradation III |
| PWY-5076 | leucine degradation III |
| BRANCHED-CHAIN-AA-SYN-PWY | superpathway of leucine, valine, and isoleucine biosynthesis |
| VALSYN-PWY | valine biosynthesis |
| PWY-5057 | valine degradation |
| PWY-5057 | valine degradation II |
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
branched-chain-amino-acid transaminase BAT1
Protein Entry
BCA1_YEAST
UniProt ID
Species
Yeast (S288c)
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | L-isoleucine + 2-oxoglutarate = (S)-3-methyl- 2-oxopentanoate + L-glutamate. |
| Catalytic Activity | L-leucine + 2-oxoglutarate = 4-methyl-2- oxopentanoate + L-glutamate. |
| Catalytic Activity | L-valine + 2-oxoglutarate = 3-methyl-2- oxobutanoate + L-glutamate. |
| Cofactor | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
| Developmental Stage | Highly expressed during logarithmic phase of growth. Down-regulated during the stationary phase. |
| Function | Involved in the biosynthesis of the branched chain amino acids leucine, isoleucine, and valine. Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using branched chain amino acids (leucine, isoleucine, and valine) as the amino donors. Appears to be involved in the regulation of the transition from G1 to S phase in the cell cycle. High copy suppressor of a temperature-sensitive mutation in the ABC transporter, ATM1 |
| Function | Involved in the biosynthesis of the branched chain amino acids leucine, isoleucine, and valine. Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using branched chain amino acids (leucine, isoleucine, and valine) as the amino donors. Appears to be involved in the regulation of the transition from G1 to S phase in the cell cycle. High copy suppressor of a temperature-sensitive mutation in the ABC transporter, ATM1. {ECO:0000269|PubMed:18625006, ECO:0000269|PubMed:21267457}. |
| Induction | Mainly expressed on ammonium-glucose exponential cultures (biosynthetic conditions), and repressed in the presence of leucine, isoleucine or valine |
| Induction | Mainly expressed on ammonium-glucose exponential cultures (biosynthetic conditions), and repressed in the presence of leucine, isoleucine or valine. {ECO:0000269|PubMed:21267457}. |
| Miscellaneous | Present with 87300 molecules/cell in log phase SD medium |
| Miscellaneous | Present with 87300 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Pathway | Amino-acid biosynthesis; L-isoleucine biosynthesis; L- isoleucine from 2-oxobutanoate: step 4/4. |
| Pathway | Amino-acid biosynthesis; L-leucine biosynthesis; L- leucine from 3-methyl-2-oxobutanoate: step 4/4. |
| Pathway | Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 6/6. |
| Pathway | Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4. |
| Similarity | Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family |
| Similarity | Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}. |
| Subcellular Location | Mitochondrion matrix . |
| Subcellular Location | Mitochondrion matrix {ECO:0000269|PubMed:21267457}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006861 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 398365103 | RefSeq | NP_012078 | 393 | branched-chain-amino-acid transaminase BAT1 |
Identical Sequences to LMP006861 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|
Related Sequences to LMP006861 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|