LIPID MAPS

LMPD ID

LMP006875

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Vac7p

Gene Symbol

VAC7

Synonyms

-

Chromosome

XIV

Vac7p
Refseq ID	NP_014344
Protein GI	398365209
UniProt ID	P53950
mRNA ID	NM_001182893
Length	1165
MTEEDRKLTVETETVEAPVANNLLLSNNSNVVAPNPSIPSASTSTSPLHREIVDDSVATANTTSNVVQHNLPTIDNNLMDSDATSHNQDHWHSDINRAGTSMSTSDIPTDLHLEHIGSVSSTNNNSNNALINHNPLSSHLSNPSSSLRNKKSSLLVASNPAFASDVELSKKKPAVISNNMPTSNIALYQTARSANIHGPSSTSASKAFRKASAFSNNTAPSTSNNIGSNTPPAPLLPLPSLSQQNKPKIIERPTMHVTNSREILLGENLLDDTKAKNAPANSTTHDNGPVANDGLRIPNHSNADDNENNNKMKKNKNINSGKNERNDDTSKICTTSTKTAPSTAPLGSTDNTQALTASVSSSNADNHNNNKKKTSSNNNGNNSNSASNKTNADIKNSNADLSASTSNNNAINDDSHESNSEKPTKADFFAARLATAVGENEISDSEETFVYESAANSTKNLIFPDSSSQQQQQQQQPPKQQQQQQNHGITSKISAPLLNNNKKLLSRLKNSRHISTGAILNNTIATISTNPNLNSNVMQNNNNLMSGHNHLDELSSIKQEPPHQLQQQQPPMDVQSVDSYTSDNPDSNVIAKSPDKRSSLVSLSKVSPHLLSSTSSNGNTISCPNVATNSQELEPNNDISTKKSLSNSTLRHSSANRNSNYGDNKRPLRTTVSKIFDSNPNGAPLRRYSGVPDHVNLEDYIEQPHNYPTMQNSVKKDEFYNSRNNKFPHGLNFYGDNNVIEEENNGDSSNVNRPQHTNLQHEFIPEDNESDENDIHSMFYYNHKNDLETKPLISDYGEDEDVDDYDRPNATFNSYYGSASNTHELPLHGRMPSRSNNDYYDFMVGNNTGNNNQLNEYTPLRMKRGQRHLSRTNNSIMNGSIHMNGNDDVTHSNINNNDIVGYSPHNFYSRKSPFVKVKNFLYLAFVISSLLMTGFILGFLLATNKELQDVDVVVMDNVISSSDELIFDITVSAFNPGFFSISVSQVDLDIFAKSSYLKCDSNGDCTVMEQERKILQITTNLSLVEESANNDISGGNIETVLLGTAKKLETPLKFQGGAFNRNYDVSVSSVKLLSPGSREAKHENDDDDDDDGDDGDDENNTNERQYKSKPNARDDKEDDTKKWKLLIKHDYELIVRGSMKYEVPFFNTQKSTAIQKDSMVHPGKK

Entrez Gene ID

Gene Name

Vac7p

Gene Symbol

VAC7

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0070772	IDA:SGD	C	PAS complex
GO:0000329	IDA:SGD	C	fungal-type vacuole membrane
GO:0016021	IDA:SGD	C	integral component of membrane
GO:0005774	IDA:UniProtKB	C	vacuolar membrane
GO:0033674	IGI:SGD	P	positive regulation of kinase activity
GO:0010513	IGI:SGD	P	positive regulation of phosphatidylinositol biosynthetic process

Accession	Description
IPR024260	Vac7

Gene Name

Vac7p

Protein Entry

VAC7_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Function	The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Positively regulates FAB1 kinase activity. Major activator of FAB1 during hyperosmotic shock and can elevate levels of PtdIns(3,5)P2 in the absence of VAC14 and FIG4. Directly involved in vacuolar membrane scission. Required for normal vacuole acidification, inheritance and morphology. {ECO:0000269\|PubMed:11950935, ECO:0000269\|PubMed:16492811, ECO:0000269\|PubMed:19037259, ECO:0000269\|PubMed:9372916}.
Interaction	Q06708:VAC14; NbExp=4; IntAct=EBI-28714, EBI-27189;
Ptm	N-glycosylated
Ptm	N-glycosylated. {ECO:0000269\|PubMed:19756047}.
Subcellular Location	Vacuole membrane ; Single- pass type II membrane protein {ECO:0000269\|PubMed:19037259, ECO:0000269\|PubMed:9372916}.
Subcellular Location	Vacuole membrane {ECO:0000269\|PubMed:19037259, ECO:0000269\|PubMed:9372916}; Single- pass type II membrane protein {ECO:0000269\|PubMed:19037259, ECO:0000269\|PubMed:9372916}.
Subunit	Component of the PI(3,5)P2 regulatory complex, composed of ATG18, FIG4, FAB1, VAC14 and VAC7. VAC14 nucleates the assembly of the complex and serves as a scaffold
Subunit	Component of the PI(3,5)P2 regulatory complex, composed of ATG18, FIG4, FAB1, VAC14 and VAC7. VAC14 nucleates the assembly of the complex and serves as a scaffold. {ECO:0000269\|PubMed:19037259}.