Gene/Proteome Database (LMPD)

LMPD ID
LMP006885
Gene ID
856008
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Eri1p
Gene Symbol
ERI1
Synonyms
RIN1
Alternate Names
Eri1p
Chromosome
XVI

Proteins

Eri1p
Refseq ID NP_690846
Protein GI 23270400
UniProt ID P62651
mRNA ID NM_001184515
Length 68
RefSeq Status PROVISIONAL
MRPRDQGFLVLGFTYSVLLISLATFYWLRNNDSFLHYWCVLLLCPATLWLWALIAWCDSEMFASSKDE

Gene Information

Entrez Gene ID
856008
Gene Name
Eri1p
Gene Symbol
ERI1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IDA:SGD C endoplasmic reticulum membrane
GO:0000506 IPI:SGD C glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005095 IPI:SGD F GTPase inhibitor activity
GO:0006506 IMP:SGD P GPI anchor biosynthetic process
GO:0043086 IPI:GOC P negative regulation of catalytic activity
GO:0007265 IMP:SGD P Ras protein signal transduction

KEGG Pathway Links

KEGG Pathway ID Description
ko00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
sce00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
sce01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description

UniProt Annotations

Entry Information

Gene Name
Eri1p
Protein Entry
ERI1_YEAST
UniProt ID
P62651
Species
Yeast (S288c)

Comments

Comment Type Description
Disruption Phenotype Defects cause hyperactive Ras phenotypes, probably due to diminished GPI-anchor protein production. {ECO:0000269|PubMed:12832483}.
Function Probable component of the GPI-GlcNAc transferase (GPI- GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI- anchors for cell surface proteins. Ras may inhibit the enzyme activity of the GPI-GnT complex via the association between ERI1 and RAS2. {ECO:0000269|PubMed:12832483, ECO:0000269|PubMed:15163411}.
Pathway Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:12832483}; Multi-pass membrane protein {ECO:0000269|PubMed:12832483}.
Subunit Interacts with GTP-bound RAS2 in an effector loop- dependent manner. Interacts with GPI2, suggesting that it is a component of the GPI-GnT complex, probably composed of GPI1, GPI2, GPI3, GPI15 and ERI1. {ECO:0000269|PubMed:12832483, ECO:0000269|PubMed:15163411}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006885 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
23270400 RefSeq NP_690846 68 Eri1p

Identical Sequences to LMP006885 proteins

Reference Database Accession Length Protein Name
GI:23270400 DBBJ GAA26877.1 68 K7_Eri1p [Saccharomyces cerevisiae Kyokai no. 7]
GI:23270400 GenBank EWG85599.1 68 Eri1p [Saccharomyces cerevisiae R008]
GI:23270400 GenBank EWG88448.1 68 Eri1p [Saccharomyces cerevisiae P301]
GI:23270400 GenBank EWG92732.1 68 Eri1p [Saccharomyces cerevisiae R103]
GI:23270400 GenBank EWH15781.1 68 Eri1p [Saccharomyces cerevisiae P283]
GI:23270400 gnl McCuskerlabDuke 68 Eri1p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP006885 proteins

Reference Database Accession Length Protein Name
GI:23270400 GenBank EDO14349.1 68 hypothetical protein Kpol_1074p2 [Vanderwaltozyma polyspora DSM 70294]
GI:23270400 GenBank EDV11124.1 68 phosphatidylinositol N-acetylglucosaminyltransferase ERI1 subunit [Saccharomyces cerevisiae RM11-1a]
GI:23270400 GenBank EJS41446.1 68 eri1p [Saccharomyces arboricola H-6]
GI:23270400 GenBank EJT43108.1 68 ERI1-like protein [Saccharomyces kudriavzevii IFO 1802]
GI:23270400 RefSeq XP_001642207.1 68 hypothetical protein Kpol_1074p2 [Vanderwaltozyma polyspora DSM 70294]
GI:23270400 RefSeq XP_003679063.1 67 hypothetical protein TDEL_0A05200 [Torulaspora delbrueckii]