Gene/Proteome Database (LMPD)
Proteins
| Pry3p | |
|---|---|
| Refseq ID | NP_012457 |
| Protein GI | 6322383 |
| UniProt ID | P47033 |
| mRNA ID | NM_001181511 |
| Length | 881 |
| MLEFPISVLLGCLVAVKAQTTFPNFESDVLNEHNKFRALHVDTAPLTWSDTLATYAQNYADQYDCSGVLTHSDGPYGENLALGYTDTGAVDAWYGEISKYNYSNPGFSESTGHFTQVVWKSTAEIGCGYKYCGTTWNNYIVCSYNPPGNYLGEFAEEVEPLISTVSSSSSSSSSTSTTSDTVSTISSSIMPAVAQGYTTTVSSAASSSSLKSTTINPAKTATLTASSSTVITSSTESVGSSTVSSASSSSVTTSYATSSSTVVSSDATSSTTTTSSVATSSSTTSSDPTSSTAAASSSDPASSSAAASSSASTENAASSSSAISSSSSMVSAPLSSTLTTSTASSRSVTSNSVNSVKFANTTVFSAQTTSSVSASLSSSVAADDIQGSTSKEATSSVSEHTSIVTSATNAAQYATRLGSSSRSSSGAVSSSAVSQSVLNSVIAVNTDVSVTSVSSTAHTTKDTATTSVTASESITSETAQASSSTEKNISNSAATSSSIYSNSASVSGHGVTYAAEYAITSEQSSALATSVPATNCSSIVKTTTLENSSTTTITAITKSTTTLATTANNSTRAATAVTIDPTLDPTDNSASPTDNAKHTSTYGSSSTGASLDSLRTTTSISVSSNTTQLVSTCTSESDYSDSPSFAISTATTTESNLITNTITASCSTDSNFPTSAASSTDETAFTRTISTSCSTLNGASTQTSELTTSPMKTNTVVPASSFPSTTTTCLENDDTAFSSIYTEVNAATIINPGETSSLASDFATSEKPNEPTSVKSTSNEGTSSTTTTYQQTVATLYAKPSSTSLGARTTTGSNGRSTTSQQDGSAMHQPTSSIYTQLKEGTSTTAKLSAYEGAATPLSIFQCNSLAGTIAAFVVAVLFAF | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0031225 | IEA:UniProtKB-KW | C | anchored component of membrane |
| GO:0005576 | IEA:UniProtKB-KW | C | extracellular region |
| GO:0009277 | IDA:SGD | C | fungal-type cell wall |
| GO:0015918 | IMP:SGD | P | sterol transport |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative promoter usage; Named isoforms=2; Name=Long; IsoId=P47033-1; Sequence=Displayed; Name=Short; Synonyms=+452 PRY3; IsoId=P47033-2; Sequence=Not described; Note=Produced by alternative promoter usage.; |
| Alternative Products | Event=Alternative promoter usage; Named isoforms=2; Name=Long; IsoId=P47033-1; Sequence=Displayed; Name=Short; Synonyms=+452 PRY3; IsoId=P47033-2; Sequence=Not described; Note=Produced by alternative promoter usage.; |
| Function | Isoform Long: The full length isoform (isoform Long) is a daughter cell-specific cell wall protein required for efficient export of lipids such as acetylated sterols. Acts in detoxification of hydrophobic compounds. Involved in tolerance to organic solvents such as dimethyl sulfoxide (DMSO). Plays also a role as an inhibitor of mating. STE12 is utilized as a repressor of full-length PRY3 transcription, ensuring efficient mating. |
| Function | Isoform Short: There is no evidence that production of the short PRY3 transcript (isoform Short) is anything more than an adventitious by-product of the mechanism responsible for the repression of the full-length transcript. Moreover, no disadvantage is detectable for cells unable to make the short transcript (PubMed:16940175) |
| Function | Isoform Short: There is no evidence that production of the short PRY3 transcript (isoform Short) is anything more than an adventitious by-product of the mechanism responsible for the repression of the full-length transcript. Moreover, no disadvantage is detectable for cells unable to make the short transcript (PubMed:16940175). {ECO:0000269|PubMed:16940175}. |
| Induction | Expressed specifically in daughter cells through activation by the transcription factor ACE2. STE12 represses expression of the full length transcript and induces expression of the short form. STE12-binding to pheromone response elements (PREs) at positions -175 and -161 prevents SPT15 from binding TATA-box 1 and thus it binds TATA-box 2 at position +385 and directs internal transcription initiation at position +452 |
| Induction | Expressed specifically in daughter cells through activation by the transcription factor ACE2. STE12 represses expression of the full length transcript and induces expression of the short form. STE12-binding to pheromone response elements (PREs) at positions -175 and -161 prevents SPT15 from binding TATA-box 1 and thus it binds TATA-box 2 at position +385 and directs internal transcription initiation at position +452. {ECO:0000269|PubMed:11747810, ECO:0000269|PubMed:16940175}. |
| Ptm | The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer. |
| Similarity | Belongs to the CRISP family |
| Similarity | Belongs to the CRISP family. {ECO:0000305}. |
| Similarity | Contains 1 SCP domain |
| Similarity | Contains 1 SCP domain. {ECO:0000305}. |
| Subcellular Location | Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP). The short isoform lacks the predicted signal peptide and might have an alternate localization. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006927 (as displayed in Record Overview)
Identical Sequences to LMP006927 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|
Related Sequences to LMP006927 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|