LIPID MAPS

LMPD ID

LMP006952

Gene ID

851464

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Pmt5p

Gene Symbol

PMT5

Synonyms

-

Chromosome

IV

EC Number

2.4.1.109 ;

Pmt5p
Refseq ID	NP_010190
Protein GI	6320109
UniProt ID	P52867
mRNA ID	NM_001180152
Length	743
MNKEHLLKVDPIPDVTIKRGPLRSFLITKPCDNLSSLRTVTSSKEKLLVGCLLIFTAIVRLHNISLPNSVVFGENEVGTFVSQYVNNIFFTDVHPPLVAMLYATVSSVFGYKGLFNYGNIGTEYTANVPYVAMRFFSATLGIVSVLVLYLTLRVSGVKIAVAAICAVCFAIENSFVTLSRFTLIEGPFVFFMACAVYFFRRSELYLPNSCKANKSLLAASIALGFAVSSKWAGLFTIAWAGIIVLWRVWFMIGDLSRPIGSSIKYMAFQFTCLLAIPAFIYFLIFSVHIKTLNVNGISSSFFPAEFRKTLKYNNVIKETVAEVAVGSAVSLNHVGTAGGYLHSHLHNYPAGSMQQQVTLYPHIDQNNKWIIELAEHPNENVTSFQNLTDGTIIKLRQLKNGCRLHSHDHKPPVSQNADWQKEVSCYGYEGFEGDINDDWIIEIDKKRSEPGPAQEHIRAIETKFRLKHYLTGCYLFSHPEKLPEWGFGQQEVTCAYFAREDLTSWYIEENENEISLPNPEKVSYKKMSFWQKFVAIHKFMFYLNNYMDTSHAYSSEPKTWPLMLRGIDFWNENGREVYFLGNAVLWWSVTAFICTFIIGVAVELLAWKLGVNILRDKHIINFHYQVFQYLLGFAAHYFPYFFVGQKLFLYDYLPAYYFGILAFGHALDLISTYISNKRNNTGYIVVAIFMVVCFYFFSEHSPLIYATGWSSNLCKRSKWLGSWDFYCNSLLLSDSHYELNAES

Entrez Gene ID

851464

Gene Name

Pmt5p

Gene Symbol

PMT5

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0097584	IDA:SGD	C	dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex
GO:0097585	IDA:SGD	C	dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0004169	ISS:SGD	F	dolichyl-phosphate-mannose-protein mannosyltransferase activity
GO:0035269	ISS:SGD	P	protein O-linked mannosylation

KEGG Pathway Links

KEGG Pathway ID	Description
ko00514	Other types of O-glycan biosynthesis
sce00514	Other types of O-glycan biosynthesis

InterPro Annotations

Accession	Description
IPR027004	Dolichyl-phosphate-mannose-protein mannosyltransferase 1/5
IPR003342	Glycosyl transferase, family 39
IPR027005	Glycosyltransferase 39 like
IPR016093	MIR_motif

Entry Information

Gene Name

Pmt5p

Protein Entry

PMT5_YEAST

UniProt ID

P52867

Species

Yeast (S288c)

Comments

Comment Type	Description
Catalytic Activity	Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein
Catalytic Activity	Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein. {ECO:0000250\|UniProtKB:P33775}.
Function	Protein O-mannosyltransferase involved in O- glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT3 and more rarely with PMT2 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins
Function	Protein O-mannosyltransferase involved in O- glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT3 and more rarely with PMT2 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. {ECO:0000303\|PubMed:12551906}.
Interaction	P31382:PMT2; NbExp=2; IntAct=EBI-13591, EBI-13573;
Pathway	Protein modification; protein glycosylation
Pathway	Protein modification; protein glycosylation. {ECO:0000305}.
Similarity	Belongs to the glycosyltransferase 39 family
Similarity	Belongs to the glycosyltransferase 39 family. {ECO:0000305}.
Similarity	Contains 3 MIR domains. {ECO:0000255\|PROSITE- ProRule:PRU00131}.
Subcellular Location	Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000250\|UniProtKB:P33775}; Multi-pass membrane protein {ECO:0000255}.
Subunit	PMT3 and PMT5 form a functional heterodimer. Forms also a minor complex with PMT2
Subunit	PMT3 and PMT5 form a functional heterodimer. Forms also a minor complex with PMT2. {ECO:0000269\|PubMed:12551906}.