Gene/Proteome Database (LMPD)

LMPD ID
LMP006978
Gene ID
851207
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
aminophospholipid-translocating P4-type ATPase DRS2
Gene Symbol
DRS2
Synonyms
FUN38; SWA3
Alternate Names
aminophospholipid-translocating P4-type ATPase DRS2
Chromosome
I
EC Number
3.6.3.1

Proteins

aminophospholipid-translocating P4-type ATPase DRS2
Refseq ID NP_009376
Protein GI 330443374
UniProt ID P39524
mRNA ID NM_001178171
Length 1355
RefSeq Status PROVISIONAL
MNDDRETPPKRKPGEDDTLFDIDFLDDTTSHSGSRSKVTNSHANANYIPPSHVLPEETIDLDADDDNIENDVHENLFMSNNHDDQTSWNANRFDSDAYQPQSLRAVKPPGLFARFGNGLKNAFTFKRKKGPESFEMNHYNAVTNNELDDNYLDSRNKFNIKILFNRYILRKNVGDAEGNGEPRVIHINDSLANSSFGYSDNHISTTKYNFATFLPKFLFQEFSKYANLFFLCTSAIQQVPHVSPTNRYTTIGTLLVVLIVSAMKECIEDIKRANSDKELNNSTAEIFSEAHDDFVEKRWIDIRVGDIIRVKSEEPIPADTIILSSSEPEGLCYIETANLDGETNLKIKQSRVETAKFIDVKTLKNMNGKVVSEQPNSSLYTYEGTMTLNDRQIPLSPDQMILRGATLRNTAWIFGLVIFTGHETKLLRNATATPIKRTAVEKIINRQIIALFTVLIVLILISSIGNVIMSTADAKHLSYLYLEGTNKAGLFFKDFLTFWILFSNLVPISLFVTVELIKYYQAFMIGSDLDLYYEKTDTPTVVRTSSLVEELGQIEYIFSDKTGTLTRNIMEFKSCSIAGHCYIDKIPEDKTATVEDGIEVGYRKFDDLKKKLNDPSDEDSPIINDFLTLLATCHTVIPEFQSDGSIKYQAASPDEGALVQGGADLGYKFIIRKPNSVTVLLEETGEEKEYQLLNICEFNSTRKRMSAIFRFPDGSIKLFCKGADTVILERLDDEANQYVEATMRHLEDYASEGLRTLCLAMRDISEGEYEEWNSIYNEAATTLDNRAEKLDEAANLIEKNLILIGATAIEDKLQDGVPETIHTLQEAGIKIWVLTGDRQETAINIGMSCRLLSEDMNLLIINEETRDDTERNLLEKINALNEHQLSTHDMNTLALVIDGKSLGFALEPELEDYLLTVAKLCKAVICCRVSPLQKALVVKMVKRKSSSLLLAIGDGANDVSMIQAAHVGVGISGMEGMQAARSADIAVGQFKFLKKLLLVHGSWSYQRISVAILYSFYKNTALYMTQFWYVFANAFSGQSIMESWTMSFYNLFFTVWPPFVIGVFDQFVSSRLLERYPQLYKLGQKGQFFSVYIFWGWIINGFFHSAIVFIGTILIYRYGFALNMHGELADHWSWGVTVYTTSVIIVLGKAALVTNQWTKFTLIAIPGSLLFWLIFFPIYASIFPHANISREYYGVVKHTYGSGVFWLTLIVLPIFALVRDFLWKYYKRMYEPETYHVIQEMQKYNISDSRPHVQQFQNAIRKVRQVQRMKKQRGFAFSQAEEGGQEKIVRMYDTTQKRGKYGELQDASANPFNDNNGLGSNDFESAEPFIENPFADGNQNSNRFSSSRDDISFDI

Gene Information

Entrez Gene ID
851207
Gene Name
aminophospholipid-translocating P4-type ATPase DRS2
Gene Symbol
DRS2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005802 IDA:SGD C trans-Golgi network
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0019829 IEA:InterPro F cation-transporting ATPase activity
GO:0000287 IEA:InterPro F magnesium ion binding
GO:0004012 IMP:SGD F phospholipid-translocating ATPase activity
GO:0032456 IMP:SGD P endocytic recycling
GO:0006897 IGI:SGD P endocytosis
GO:0006886 IGI:SGD P intracellular protein transport
GO:0045332 IMP:SGD P phospholipid translocation
GO:0006892 IMP:SGD P post-Golgi vesicle-mediated transport
GO:0000028 IMP:SGD P ribosomal small subunit assembly

REACTOME Pathway Links

REACTOME Pathway ID Description
5618495 Ion channel transport
5618494 Ion transport by P-type ATPases
5618037 Transmembrane transport of small molecules

Domain Information

InterPro Annotations

Accession Description
IPR008250 ATPase_P-typ_transduc_dom_A
IPR001757 Cation_transp_P_typ_ATPase
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N
IPR018303 P-type ATPase, phosphorylation site
IPR006539 P-type ATPase, subfamily IV

UniProt Annotations

Entry Information

Gene Name
aminophospholipid-translocating P4-type ATPase DRS2
Protein Entry
ATC3_YEAST
UniProt ID
P39524
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
Function This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}.
Miscellaneous Present with 606 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. {ECO:0000305}.
Subcellular Location Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12372257, ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:12372257, ECO:0000269|PubMed:14562095}.
Subunit Interacts with CDC50. {ECO:0000269|PubMed:15090616}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006978 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
330443374 RefSeq NP_009376 1355 aminophospholipid-translocating P4-type ATPase DRS2

Identical Sequences to LMP006978 proteins

Reference Database Accession Length Protein Name
GI:330443374 GenBank EIW12337.1 1355 Drs2p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:330443374 SwissProt P39524.2 1355 RecName: Full=Probable phospholipid-transporting ATPase DRS2 [Saccharomyces cerevisiae S288c]
GI:330443374 Third Party Genbank DAA06962.2 1355 TPA: aminophospholipid-translocating P4-type ATPase DRS2 [Saccharomyces cerevisiae S288c]

Related Sequences to LMP006978 proteins

Reference Database Accession Length Protein Name
GI:330443374 EMBL CAY77625.1 1355 Drs2p [Saccharomyces cerevisiae EC1118]
GI:330443374 GenBank EGA80099.1 1355 Drs2p [Saccharomyces cerevisiae Vin13]
GI:330443374 GenBank EWG87896.1 1355 Drs2p [Saccharomyces cerevisiae R008]
GI:330443374 GenBank EWG97706.1 1355 Drs2p [Saccharomyces cerevisiae R103]
GI:330443374 GenBank EWH19704.1 1355 Drs2p [Saccharomyces cerevisiae P283]
GI:330443374 gnl McCuskerlabDuke 1355 Drs2p [Saccharomyces cerevisiae YJM993]