LIPID MAPS

LMPD ID

LMP006994

Gene ID

856652

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

phosphoacetylglucosamine mutase PCM1

Gene Symbol

PCM1

Synonyms

AGM1

Chromosome

V

EC Number

5.4.2.3

phosphoacetylglucosamine mutase PCM1
Refseq ID	NP_010856
Protein GI	6320777
UniProt ID	P38628
mRNA ID	NM_001178873
Length	557
MKVDYEQLCKLYDDTCRTKNVQFSYGTAGFRTLAKNLDTVMFSTGILAVLRSLKLQGQYVGVMITASHNPYQDNGVKIVEPDGSMLLATWEPYAMQLANAASFATNFEEFRVELAKLIEHEKIDLNTTVVPHIVVGRDSRESSPYLLRCLTSSMASVFHAQVLDLGCVTTPQLHYITDLSNRRKLEGDTAPVATEQDYYSFFIGAFNELFATYQLEKRLSVPKLFIDTANGIGGPQLKKLLASEDWDVPAEQVEVINDRSDVPELLNFECGADYVKTNQRLPKGLSPSSFDSLYCSFDGDADRVVFYYVDSGSKFHLLDGDKISTLFAKFLSKQLELAHLEHSLKIGVVQTAYANGSSTAYIKNTLHCPVSCTKTGVKHLHHEAATQYDIGIYFEANGHGTIIFSEKFHRTIKSELSKSKLNGDTLALRTLKCFSELINQTVGDAISDMLAVLATLAILKMSPMDWDEEYTDLPNKLVKCIVPDRSIFQTTDQERKLLNPVGLQDKIDLVVAKYPMGRSFVRASGTEDAVRVYAECKDSSKLGQFCDEVVEHVKASA

Entrez Gene ID

856652

Gene Name

phosphoacetylglucosamine mutase PCM1

Gene Symbol

PCM1

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0000287	IEA:InterPro	F	magnesium ion binding
GO:0004610	IMP:SGD	F	phosphoacetylglucosamine mutase activity
GO:0006048	IEA:UniProtKB-UniPathway	P	UDP-N-acetylglucosamine biosynthetic process
GO:0034221	IMP:SGD	P	fungal-type cell wall chitin biosynthetic process

KEGG Pathway Links

KEGG Pathway ID	Description
ko00520	Amino sugar and nucleotide sugar metabolism
sce00520	Amino sugar and nucleotide sugar metabolism
sce01110	Biosynthesis of secondary metabolites

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
UDPNACETYLGALSYN-PWY	UDP-N-acetyl-D-glucosamine biosynthesis II
UDPNACETYLGALSYN-PWY	UDP-N-acetyl-D-glucosamine biosynthesis II
UDPNAGSYN-YEAST-PWY	UDP-N-acetylglucosamine biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID	Description
5618350	Asparagine N-linked glycosylation
5618349	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
5618074	Metabolism of proteins
5618285	Post-translational protein modification
5618532	Synthesis of UDP-N-acetyl-glucosamine
5618348	Synthesis of substrates in N-glycan biosythesis

InterPro Annotations

Accession	Description
IPR005843	A-D-PHexomutase_C
IPR016066	A-D-PHexomutase_CS
IPR005844	A-D-PHexomutase_a/b/a-I
IPR016055	A-D-PHexomutase_a/b/a-I/II/III
IPR005845	A-D-PHexomutase_a/b/a-II
IPR016657	PAGM

Entry Information

Gene Name

phosphoacetylglucosamine mutase PCM1

Protein Entry

AGM1_YEAST

UniProt ID

P38628

Species

Yeast (S288c)

Comments

Comment Type	Description
Catalytic Activity	N-acetyl-alpha-D-glucosamine 1-phosphate = N- acetyl-D-glucosamine 6-phosphate
Catalytic Activity	N-acetyl-alpha-D-glucosamine 1-phosphate = N- acetyl-D-glucosamine 6-phosphate. {ECO:0000269\|PubMed:8174553}.
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250\|UniProtKB:Q9P4V2}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250\|UniProtKB:Q9P4V2};
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Note=Binds 1 Mg(2+) ion per subunit. ;
Disruption Phenotype	Results in undivided strings of cells and growth arrest after approximately 5 division cycles
Disruption Phenotype	Results in undivided strings of cells and growth arrest after approximately 5 division cycles. {ECO:0000269\|PubMed:8174553}.
Function	Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins (PubMed:8174553). Also has phosphoglucomutase activity (PubMed:8119301). {ECO:0000269\|PubMed:8119301, ECO:0000269\|PubMed:8174553}.
Interaction	P40151:MGS1; NbExp=2; IntAct=EBI-2351, EBI-29152;
Miscellaneous	Present with 14700 molecules/cell in log phase SD medium
Miscellaneous	Present with 14700 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Pathway	Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2
Pathway	Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2. {ECO:0000305\|PubMed:8174553}.
Similarity	Belongs to the phosphohexose mutase family
Similarity	Belongs to the phosphohexose mutase family. {ECO:0000305}.
Subcellular Location	Cytoplasm . Nucleus .
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:14562095}. Nucleus {ECO:0000269\|PubMed:14562095}.