Gene/Proteome Database (LMPD)

LMPD ID
LMP006998
Gene ID
855732
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
citrate (Si)-synthase CIT1
Gene Symbol
CIT1
Synonyms
LYS6
Chromosome
XIV
EC Number
2.3.3.16

Proteins

citrate (Si)-synthase CIT1
Refseq ID NP_014398
Protein GI 6324328
UniProt ID P00890
mRNA ID NM_001183178
Length 479
MSAILSTTSKSFLSRGSTRQCQNMQKALFALLNARHYSSASEQTLKERFAEIIPAKAEEIKKFKKEHGKTVIGEVLLEQAYGGMRGIKGLVWEGSVLDPEEGIRFRGRTIPEIQRELPKAEGSTEPLPEALFWLLLTGEIPTDAQVKALSADLAARSEIPEHVIQLLDSLPKDLHPMAQFSIAVTALESESKFAKAYAQGVSKKEYWSYTFEDSLDLLGKLPVIASKIYRNVFKDGKITSTDPNADYGKNLAQLLGYENKDFIDLMRLYLTIHSDHEGGNVSAHTTHLVGSALSSPYLSLAAGLNGLAGPLHGRANQEVLEWLFKLREEVKGDYSKETIEKYLWDTLNAGRVVPGYGHAVLRKTDPRYTAQREFALKHFPDYELFKLVSTIYEVAPGVLTKHGKTKNPWPNVDSHSGVLLQYYGLTEASFYTVLFGVARAIGVLPQLIIDRAVGAPIERPKSFSTEKYKELVKKIESKN

Gene Information

Entrez Gene ID
855732
Gene Name
citrate (Si)-synthase CIT1
Gene Symbol
CIT1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0005758 TAS:Reactome C mitochondrial intermembrane space
GO:0005739 IDA:SGD C mitochondrion
GO:0004108 IDA:SGD F citrate (Si)-synthase activity
GO:0046356 IDA:SGD P acetyl-CoA catabolic process
GO:0044262 IEA:InterPro P cellular carbohydrate metabolic process
GO:0006101 TAS:SGD P citrate metabolic process
GO:0006537 TAS:SGD P glutamate biosynthetic process
GO:0006099 TAS:SGD P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
ko01210 2-Oxocarboxylic acid metabolism
sce01210 2-Oxocarboxylic acid metabolism
ko01230 Biosynthesis of amino acids
sce01230 Biosynthesis of amino acids
sce01110 Biosynthesis of secondary metabolites
ko01200 Carbon metabolism
sce01200 Carbon metabolism
ko00020 Citrate cycle (TCA cycle)
sce00020 Citrate cycle (TCA cycle)
M00009 Citrate cycle (TCA cycle, Krebs cycle)
sce_M00009 Citrate cycle (TCA cycle, Krebs cycle)
M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
sce_M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
ko00630 Glyoxylate and dicarboxylate metabolism
sce00630 Glyoxylate and dicarboxylate metabolism
M00012 Glyoxylate cycle
sce_M00012 Glyoxylate cycle
sce01100 Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID Description
TCA-EUK-PWY-YEAST TCA cycle, aerobic respiration

REACTOME Pathway Links

REACTOME Pathway ID Description
5618051 Citric acid cycle (TCA cycle)
5618023 Metabolism
5618052 Pyruvate metabolism and Citric Acid (TCA) cycle
5618053 The citric acid (TCA) cycle and respiratory electron transport

Domain Information

InterPro Annotations

Accession Description
IPR019810 Citrate synthase active site
IPR010109 Citrate synthase, eukaryotic
IPR002020 Citrate synthase-like
IPR016141 Citrate synthase-like, core
IPR016142 Citrate synthase-like, large alpha subdomain

UniProt Annotations

Entry Information

Gene Name
citrate (Si)-synthase CIT1
Protein Entry
CISY1_YEAST
UniProt ID
P00890
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA
Catalytic Activity Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA. {ECO:0000255|PROSITE-ProRule:PRU10117}.
Miscellaneous Citrate synthase is found in nearly all cells capable of oxidative metabolism.
Pathway Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.
Similarity Belongs to the citrate synthase family
Similarity Belongs to the citrate synthase family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix .
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:11502169}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006998 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6324328 RefSeq NP_014398 479 citrate (Si)-synthase CIT1

Identical Sequences to LMP006998 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP006998 proteins

Reference Database Accession Length Protein Name