LIPID MAPS

LMPD ID

LMP007000

Gene ID

855443

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Caf120p

Gene Symbol

CAF120

Synonyms

-

Chromosome

XIV

Caf120p
Refseq ID	NP_014121
Protein GI	6324051
UniProt ID	P53836
mRNA ID	NM_001183116
Length	1060
MRIFSGDNKVVDSLASNPGLMSPSNFGGDFGSRLKVNVTSKKKLNDSSPTSPMESSPVSPELVPILTLLNAHTHRRYHEGVFLILQDLNNNGTHAARKWKDVYGVLLGTQLALWDAKELAEFTDPSCPVSEKKLKEVASKPTYINLTDATLRTLDNSDNIVMECGKNLTNALVVSTTLKNRYFLQFGNKESFNAWNSAIRLCLYECSSLQEAYTGAFISSRGAKLGDIRILLTNRKYDYKDWVSVRFGAGMPWKRCYAVISQSSSKKKGHFGEINLYENDKKVKKNHAMATIVEAKALYAVYPSSPKLIDSSTIIKVVGSVKFEKKESAQEKDVFIMPEKHQAVPSYDTIIRFLIPAMDTFKLYGRPEKLLSSKNDPHSLLFGLPVLPHIYYLEVEDLLPLTNSVSSLHWSNNEWKEHISDILQRKIAQGYCGCNSTSNITSPLPSPFLGSADLFERADGVLSPKLSYGSKSSSNNSSKNSLPKRERVKLSSSSEQDLNNSDSPSIKRKSPPLVISESPHKVHTPTDASFRTRVTEGSPYAKQRHPKPFASSVNDSPSDRAKSRTVPYNNNDRKATTPEKFERGETSCGKNVDESLEKVRNMKLEIPESNFDKFMTDKNLLSVDSKCSNEKKLSVESDLSAIYEKYSNGPFGHTEGLNGSSDETYLRFQRASVHSESNYNSRKSFTPSDFSNGNEEEHAVLQELNSLTQRINELGMESINSNSDSDRINGSYSQVDFGNNNDEDDMNLFDPDFMAQDQLRAEERDYNKDDRTPLAKVPAAFQSTGLGITPDDDIERQYITEHRSRHEVPKRSPEKPSNPLEIGNPYAKPGTRLNTTHTHSKTDRSITPQRGQPVPSGQQISSYVQPANINSPNKMYGANNSAMGSPRNPKTRAPPGPYNQGWNNRPSPSNIYQRPHPSDTQPQAYHLPGNPYSTGNRPNMQAQYHPQQVPMPILQQPNRPYQPYAMNTHMGSPGGYAGAAPPFQPANVNYNTRPQQPWPTPNSPSAHYRPPPNLNQPQNGSAGYYRPPAPQLQNSQARPQKKDGFSQFMPSATTKNPYAQ

Entrez Gene ID

855443

Gene Name

Caf120p

Gene Symbol

CAF120

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IEA:UniProtKB-KW	C	cytoplasm
GO:0005634	IEA:UniProtKB-KW	C	nucleus
GO:0006357	IPI:SGD	P	regulation of transcription from RNA polymerase II promoter
GO:0006351	IEA:UniProtKB-KW	P	transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID	Description
ko03018	RNA degradation
sce03018	RNA degradation

InterPro Annotations

Accession	Description
IPR001849	Pleckstrin homology domain
IPR011993	Pleckstrin homology-like domain

Entry Information

Gene Name

Caf120p

Protein Entry

CA120_YEAST

UniProt ID

P53836

Species

Yeast (S288c)

Comments

Comment Type	Description
Function	Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC- type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Miscellaneous	Present with 1380 molecules/cell in log phase SD medium
Miscellaneous	Present with 1380 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the CAF120 family
Similarity	Belongs to the CAF120 family. {ECO:0000305}.
Similarity	Contains 1 PH domain. {ECO:0000255\|PROSITE- ProRule:PRU00145}.
Subcellular Location	Cytoplasm . Nucleus . Bud neck .
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:14562095}. Nucleus {ECO:0000269\|PubMed:14562095}. Bud neck {ECO:0000269\|PubMed:14562095}.
Subunit	Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, CAF120, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with NOT1. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex
Subunit	Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, CAF120, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with NOT1. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex. {ECO:0000269\|PubMed:11733989}.