Gene/Proteome Database (LMPD)

LMPD ID
LMP007077
Gene ID
853307
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
sphinganine kinase LCB3
Gene Symbol
LCB3
Synonyms
LBP1; YSR2
Alternate Names
sphinganine kinase LCB3
Chromosome
X
EC Number
3.1.3.-

Proteins

sphinganine kinase LCB3
Refseq ID NP_012401
Protein GI 6322327
UniProt ID P47013
mRNA ID NM_001181567
Length 409
RefSeq Status PROVISIONAL
MVDGLNTSNIRKRARTLSNPNDFQEPNYLLDPGNHPSDHFRTRMSKFRFNIREKLLVFTNNQSFTLSRWQKKYRSAFNDLYFTYTSLMGSHTFYVLCLPMPVWFGYFETTKDMVYILGYSIYLSGFFKDYWCLPRPRAPPLHRITLSEYTTKEYGAPSSHTANATGVSLLFLYNIWRMQESSVMVQLLLSCVVLFYYMTLVFGRIYCGMHGILDLVSGGLIGIVCFIVRMYFKYRFPGLRIEEHWWFPLFSVGWGLLLLFKHVKPVDECPCFQDSVAFMGVVSGIECCDWLGKVFGVTLVYNLEPNCGWRLTLARLLVGLPCVVIWKYVISKPMIYTLLIKVFHLKDDRNVAARKRLEATHKEGASKYECPLYIGEPKIDILGRFIIYAGVPFTVVMCSPVLFSLLNIA

Gene Information

Entrez Gene ID
853307
Gene Name
sphinganine kinase LCB3
Gene Symbol
LCB3
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:SGD C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0042392 IDA:SGD F sphingosine-1-phosphate phosphatase activity
GO:0019722 IMP:SGD P calcium-mediated signaling
GO:0016311 IDA:GOC P dephosphorylation
GO:0030148 TAS:SGD P sphingolipid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
sce00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5618508 Sphingolipid de novo biosynthesis
5618509 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase

UniProt Annotations

Entry Information

Gene Name
sphinganine kinase LCB3
Protein Entry
DS1P1_YEAST
UniProt ID
P47013
Species
Yeast (S288c)

Comments

Comment Type Description
Function Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases. Involved in endocytosis and calcium-mediated signaling. {ECO:0000269|PubMed:10477278, ECO:0000269|PubMed:10563329, ECO:0000269|PubMed:10856228, ECO:0000269|PubMed:11278643, ECO:0000269|PubMed:11967828, ECO:0000269|PubMed:12493772, ECO:0000269|PubMed:12684378, ECO:0000269|PubMed:12786943, ECO:0000269|PubMed:9195906, ECO:0000269|PubMed:9353337, ECO:0000269|PubMed:9419344}.
Ptm Glycosylated. {ECO:0000269|PubMed:12786943}.
Similarity Belongs to the type 2 lipid phosphate phosphatase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:10477278, ECO:0000269|PubMed:10563329, ECO:0000269|PubMed:9353337}; Multi-pass membrane protein {ECO:0000269|PubMed:10477278, ECO:0000269|PubMed:10563329, ECO:0000269|PubMed:9353337}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007077 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6322327 RefSeq NP_012401 409 sphinganine kinase LCB3

Identical Sequences to LMP007077 proteins

Reference Database Accession Length Protein Name
GI:6322327 GenBank EGA78299.1 409 Lcb3p [Saccharomyces cerevisiae Vin13]
GI:6322327 GenBank EHN06439.1 409 Lcb3p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6322327 GenBank EWG85002.1 409 Lcb3p [Saccharomyces cerevisiae R008]
GI:6322327 GenBank EWG95310.1 409 Lcb3p [Saccharomyces cerevisiae R103]
GI:6322327 GenBank EWH17756.1 409 Lcb3p [Saccharomyces cerevisiae P283]
GI:6322327 gnl McCuskerlabDuke 409 Lcb3p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP007077 proteins

Reference Database Accession Length Protein Name
GI:6322327 DBBJ GAA24229.1 409 K7_Lcb3p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6322327 GenBank EDN63247.1 409 dihydrosphingosine-1-phosphate phosphatase [Saccharomyces cerevisiae YJM789]
GI:6322327 GenBank EGA82295.1 366 Lcb3p [Saccharomyces cerevisiae Lalvin QA23]
GI:6322327 GenBank EHN01800.1 409 Lcb3p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6322327 GenBank EIW09727.1 409 Lcb3p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6322327 GenBank EJT43878.1 409 LCB3-like protein [Saccharomyces kudriavzevii IFO 1802]