Gene/Proteome Database (LMPD)

LMPD ID
LMP007099
Gene ID
854763
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
putative aminophospholipid-translocating P4-type ATPase NEO1
Gene Symbol
NEO1
Synonyms
-
Chromosome
IX
EC Number
3.6.3.1;

Proteins

putative aminophospholipid-translocating P4-type ATPase NEO1
Refseq ID NP_012216
Protein GI 6322141
UniProt ID P40527
mRNA ID NM_001179398
Length 1151
MPNPPSFKSHKQNLFNSNNNQHANSVDSFDLHLDDSFDAALDSLQINNNPEPLSKHNTVGDRESFEMRTVDDLDNFSNHSSDSHRKSSNTDTHPLMYDNRLSQDDNFKFTNIASSPPSSSNNIFSKALSYLKVSNTKNWSKFGSPIELSDQHIEREIHPDTTPVYDRNRYVSNELSNAKYNAVTFVPTLLYEQFKFFYNLYFLVVALSQAVPALRIGYLSSYIVPLAFVLTVTMAKEAIDDIQRRRRDRESNNELYHVITRNRSIPSKDLKVGDLIKVHKGDRIPADLVLLQSSEPSGESFIKTDQLDGETDWKLRVACPLTQNLSENDLINRISITASAPEKSIHKFLGKVTYKDSTSNPLSVDNTLWANTVLASSGFCIACVVYTGRDTRQAMNTTTAKVKTGLLELEINSISKILCACVFALSILLVAFAGFHNDDWYIDILRYLILFSTIIPVSLRVNLDLAKSVYAHQIEHDKTIPETIVRTSTIPEDLGRIEYLLSDKTGTLTQNDMQLKKIHLGTVSYTSETLDIVSDYVQSLVSSKNDSLNNSKVALSTTRKDMSFRVRDMILTLAICHNVTPTFEDDELTYQAASPDEIAIVKFTESVGLSLFKRDRHSISLLHEHSGKTLNYEILQVFPFNSDSKRMGIIVRDEQLDEYWFMQKGADTVMSKIVESNDWLEEETGNMAREGLRTLVIGRKKLNKKIYEQFQKEYNDASLSMLNRDQQMSQVITKYLEHDLELLGLTGVEDKLQKDVKSSIELLRNAGIKIWMLTGDKVETARCVSISAKLISRGQYVHTITKVTRPEGAFNQLEYLKINRNACLLIDGESLGMFLKHYEQEFFDVVVHLPTVIACRCTPQQKADVALVIRKMTGKRVCCIGDGGNDVSMIQCADVGVGIVGKEGKQASLAADFSITQFCHLTELLLWHGRNSYKRSAKLAQFVMHRGLIIAICQAVYSICSLFEPIALYQGWLMVGYATCYTMAPVFSLTLDHDIEESLTKIYPELYKELTEGKSLSYKTFFVWVLLSLFQGSVIQLFSQAFTSLLDTDFTRMVAISFTALVVNELIMVALEIYTWNKTMLVTEIATLLFYIVSVPFLGDYFDLGYMTTVNYYAGLLVILLISIFPVWTAKAIYRRLHPPSYAKVQEFATP

Gene Information

Entrez Gene ID
854763
Gene Name
putative aminophospholipid-translocating P4-type ATPase NEO1
Gene Symbol
NEO1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005768 IDA:SGD C endosome
GO:0005794 IDA:SGD C Golgi apparatus
GO:0000139 IDA:SGD C Golgi membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0015662 ISS:SGD F ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0019829 IEA:InterPro F cation-transporting ATPase activity
GO:0000287 IEA:InterPro F magnesium ion binding
GO:0004012 ISS:SGD F phospholipid-translocating ATPase activity
GO:0006897 IMP:SGD P endocytosis
GO:0034220 ISS:GOC P ion transmembrane transport
GO:0045332 ISS:GOC P phospholipid translocation
GO:0015031 IEA:UniProtKB-KW P protein transport
GO:0006890 IMP:SGD P retrograde vesicle-mediated transport, Golgi to ER
GO:0007033 IMP:SGD P vacuole organization

Domain Information

InterPro Annotations

Accession Description
IPR008250 ATPase_P-typ_transduc_dom_A
IPR001757 Cation_transp_P_typ_ATPase
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N
IPR018303 P-type ATPase, phosphorylation site
IPR006539 P-type ATPase, subfamily IV

UniProt Annotations

Entry Information

Gene Name
putative aminophospholipid-translocating P4-type ATPase NEO1
Protein Entry
ATC7_YEAST
UniProt ID
P40527
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
Function This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes
Function This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}.
Similarity Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily
Similarity Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. {ECO:0000305}.
Subcellular Location Endosome membrane {ECO:0000269|PubMed:15314152}; Multi-pass membrane protein {ECO:0000269|PubMed:15314152}. Golgi apparatus membrane {ECO:0000269|PubMed:15314152}; Multi-pass membrane protein {ECO:0000269|PubMed:15314152}.
Subcellular Location Endosome membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein .
Subunit Interacts with MON2
Subunit Interacts with MON2. {ECO:0000269|PubMed:15314152}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007099 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6322141 RefSeq NP_012216 1151 putative aminophospholipid-translocating P4-type ATPase NEO1

Identical Sequences to LMP007099 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007099 proteins

Reference Database Accession Length Protein Name