Gene/Proteome Database (LMPD)

LMPD ID
LMP007154
Gene ID
853348
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
enoyl-CoA hydratase PHS1
Gene Symbol
PHS1
Synonyms
-
Alternate Names
enoyl-CoA hydratase PHS1
Chromosome
X
EC Number
4.2.1.134

Proteins

enoyl-CoA hydratase PHS1
Refseq ID NP_012438
Protein GI 6322364
UniProt ID P40857
mRNA ID NM_001181530
Length 217
RefSeq Status PROVISIONAL
MSKKLASPLSFLPLYNLLSAVGWSYLLYLVISLYPKVGQPAFFYQTKNVATLVQCGAIIEIINSFLGVVRSPLLTTVAQVSSRLLVVLGIFQLLPNTSGVQSVVYISLLLAWSITEIVRYLYYFFMLVFKNGAPKILILLRYNLFWILYPTGVASELRIIYCALNAAESQYSLLYKRILIAAMLAYIPGFPMLFLHMVAQRKKVMKSLRSSFGKKLI

Gene Information

Entrez Gene ID
853348
Gene Name
enoyl-CoA hydratase PHS1
Gene Symbol
PHS1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000324 IDA:SGD C fungal-type vacuole
GO:0030176 IDA:SGD C integral component of endoplasmic reticulum membrane
GO:0018812 IMP:SGD F 3-hydroxyacyl-CoA dehydratase activity
GO:0004300 IDA:SGD F enoyl-CoA hydratase activity
GO:0030497 IMP:SGD P fatty acid elongation
GO:0030148 IMP:SGD P sphingolipid biosynthetic process
GO:0007034 IMP:SGD P vacuolar transport

KEGG Pathway Links

KEGG Pathway ID Description
sce01040 Biosynthesis of unsaturated fatty acids
sce_M00415 Fatty acid biosynthesis, elongation, endoplasmic reticulum
sce00062 Fatty acid elongation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-7288 fatty acid beta-oxidation (peroxisome)

Domain Information

InterPro Annotations

Accession Description
IPR007482 Protein-tyrosine phosphatase-like, PTPLA

UniProt Annotations

Entry Information

Gene Name
enoyl-CoA hydratase PHS1
Protein Entry
PHS1_YEAST
UniProt ID
P40857
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity A very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H(2)O. {ECO:0000269|PubMed:17719544, ECO:0000269|PubMed:18272525}.
Function Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis. {ECO:0000269|PubMed:17719544, ECO:0000269|PubMed:18272525}.
Similarity Belongs to the very long-chain fatty acids dehydratase HACD family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP007154 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6322364 RefSeq NP_012438 217 enoyl-CoA hydratase PHS1

Identical Sequences to LMP007154 proteins

Reference Database Accession Length Protein Name
GI:6322364 GenBank EIW09434.1 217 Phs1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6322364 GenBank EWG85031.1 217 Phs1p [Saccharomyces cerevisiae R008]
GI:6322364 GenBank EWG90313.1 217 Phs1p [Saccharomyces cerevisiae P301]
GI:6322364 GenBank EWG95037.1 217 Phs1p [Saccharomyces cerevisiae R103]
GI:6322364 GenBank EWH17784.1 217 Phs1p [Saccharomyces cerevisiae P283]
GI:6322364 gnl McCuskerlabDuke 217 Phs1p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP007154 proteins

Reference Database Accession Length Protein Name
GI:6322364 EMBL CCC67507.1 218 hypothetical protein NCAS_0A09490 [Naumovozyma castellii CBS 4309]
GI:6322364 GenBank EGA61638.1 290 Phs1p [Saccharomyces cerevisiae FostersO]
GI:6322364 GenBank EGA78316.1 290 Phs1p [Saccharomyces cerevisiae Vin13]
GI:6322364 GenBank EJT43233.1 259 PHS1-like protein [Saccharomyces kudriavzevii IFO 1802]
GI:6322364 RefSeq XP_003673888.1 218 hypothetical protein NCAS_0A09490 [Naumovozyma castellii CBS 4309]
GI:6322364 RefSeq XP_003980204.1 216 hypothetical protein NDAI_0G05450 [Naumovozyma dairenensis CBS 421]