LIPID MAPS

LMPD ID

LMP007167

Gene ID

855518

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Sps19p

Gene Symbol

SPS19

Synonyms

SPX19

Chromosome

XIV

EC Number

1.3.1.34

Sps19p
Refseq ID	NP_014197
Protein GI	99030931
UniProt ID	P32573
mRNA ID	NM_001183040
Length	292
MNTANTLDGKFVTEGSWRPDLFKGKVAFVTGGAGTICRVQTEALVLLGCKAAIVGRDQERTEQAAKGISQLAKDKDAVLAIANVDVRNFEQVENAVKKTVEKFGKIDFVIAGAAGNFVCDFANLSPNAFKSVVDIDLLGSFNTAKACLKELKKSKGSILFVSATFHYYGVPFQGHVGAAKAGIDALAKNLAVELGPLGIRSNCIAPGAIDNTEGLKRLAGKKYKEKALAKIPLQRLGSTRDIAESTVYIFSPAASYVTGTVLVVDGGMWHLGTYFGHELYPEALIKSMTSKL

Entrez Gene ID

855518

Gene Name

Sps19p

Gene Symbol

SPS19

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005782	IDA:SGD	C	peroxisomal matrix
GO:0008670	IDA:SGD	F	2,4-dienoyl-CoA reductase (NADPH) activity
GO:0030437	IMP:SGD	P	ascospore formation
GO:0009062	IDA:SGD	P	fatty acid catabolic process

KEGG Pathway Links

KEGG Pathway ID	Description
ko04146	Peroxisome
sce04146	Peroxisome

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
PWY-7337	10-cis-heptadecenoyl-CoA degradation
PWY-7337	10-cis-heptadecenoyl-CoA degradation (yeast)
PWY-7338	10-trans-heptadecenoyl-CoA degradation (reductase-dependent)
PWY-7338	10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)
PWY-6837	fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)
PWY-7307	oleate beta-oxidation (reductase-dependent)
PWY-7307	oleate beta-oxidation (reductase-dependent, yeast)

InterPro Annotations

Accession	Description
IPR002347	Glucose/ribitol dehydrogenase
IPR016040	NAD(P)-binding domain

Entry Information

Gene Name

Sps19p

Protein Entry

SPS19_YEAST

UniProt ID

P32573

Species

Yeast (S288c)

Comments

Comment Type	Description
Catalytic Activity	Trans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH
Catalytic Activity	Trans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH. {ECO:0000269\|PubMed:9268358}.
Developmental Stage	Sequentially activated during the process of meiosis and spore formation.
Function	Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Dispensable for growth and sporulation on solid acetate and oleate media, but is essential for these processes to occur on petroselineate.
Induction	By oleate. Transcription is regulated by the transcription factors PIP2, OAF1 and ADR1. Weakly induced during sporulation in diploid cells. {ECO:0000269\|PubMed:11170837, ECO:0000269\|PubMed:9268358, ECO:0000269\|PubMed:9427398}.
Sequence Caution	Sequence=AAA62403.1; Type=Erroneous initiation; Evidence= ; Sequence=AAT93138.1; Type=Erroneous initiation; Evidence= ; Sequence=CAA55506.1; Type=Erroneous initiation; Evidence= ; Sequence=CAA96103.1; Type=Erroneous initiation; Evidence= ;
Sequence Caution	Sequence=AAA62403.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAT93138.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA55506.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA96103.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the short-chain dehydrogenases/reductases (SDR) family
Similarity	Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular Location	Peroxisome .
Subcellular Location	Peroxisome {ECO:0000269\|PubMed:9268358}.
Subunit	Homodimer
Subunit	Homodimer. {ECO:0000269\|PubMed:9268358}.