Gene/Proteome Database (LMPD)

LMPD ID
LMP007220
Gene ID
855315
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
fatty acid alpha-hydroxylase
Gene Symbol
SCS7
Synonyms
FAH1
Chromosome
XIII
EC Number
1.-.-.-

Proteins

fatty acid alpha-hydroxylase
Refseq ID NP_013999
Protein GI 6323928
UniProt ID Q03529
mRNA ID NM_001182779
Length 384
MSTNTSKTLELFSKKTVQEHNTANDCWVTYQNRKIYDVTRFLSEHPGGDESILDYAGKDITEIMKDSDVHEHSDSAYEILEDEYLIGYLATDEEAARLLTNKNHKVEVQLSADGTEFDSTTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILRSDFKKDFYVDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLPVVVYHMGVALKNMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFLLHGCHHYLPMDKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGLFGYVCYDECHFFLHHSKLPPFMRKLKKYHLEHHYKNYQLGFGVTSWFWDEVFGTYLGPDAPLSKMKYE

Gene Information

Entrez Gene ID
855315
Gene Name
fatty acid alpha-hydroxylase
Gene Symbol
SCS7
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 ISS:SGD C membrane
GO:0080132 IMP:SGD F fatty acid alpha-hydroxylase activity
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0006633 IEA:UniProtKB-KW P fatty acid biosynthetic process
GO:0006673 IMP:SGD P inositolphosphoceramide metabolic process

BIOCYC Pathway Links

BIOCYC Pathway ID Description
SPHINGOLIPID-SYN-PWY sphingolipid biosynthesis
SPHINGOLIPID-SYN-PWY sphingolipid biosynthesis (yeast)

Domain Information

InterPro Annotations

Accession Description
IPR018506 Cytochrome b5, heme-binding site
IPR001199 Cytochrome b5-like heme/steroid binding domain
IPR006694 Fatty_acid_hydroxylase
IPR014430 Inositolphosphorylceramide-B hydroxylase

UniProt Annotations

Entry Information

Gene Name
fatty acid alpha-hydroxylase
Protein Entry
SCS7_YEAST
UniProt ID
Q03529
Species
Yeast (S288c)

Comments

Comment Type Description
Cofactor Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence= ;
Cofactor Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
Domain The histidine box domains may contain the active site and/or be involved in metal ion binding.
Function Ceramide hydroxylase involved in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids. Hydroxylates the very long chain fatty acid of ceramides at C2 and C3. {ECO:0000269|PubMed:12006573, ECO:0000269|PubMed:16652392, ECO:0000269|PubMed:19074599, ECO:0000269|PubMed:9353282, ECO:0000269|PubMed:9368039, ECO:0000269|PubMed:9559540}.
Miscellaneous Present with 3290 molecules/cell in log phase SD medium
Miscellaneous Present with 3290 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the sterol desaturase family. SCS7 subfamily
Similarity Belongs to the sterol desaturase family. SCS7 subfamily. {ECO:0000305}.
Similarity Contains 1 cytochrome b5 heme-binding domain
Similarity Contains 1 cytochrome b5 heme-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00279}.
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007220 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6323928 RefSeq NP_013999 384 fatty acid alpha-hydroxylase

Identical Sequences to LMP007220 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007220 proteins

Reference Database Accession Length Protein Name