LIPID MAPS

LMPD ID

LMP007236

Gene ID

851087

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

fatty acid elongase SUR4

Gene Symbol

SUR4

Synonyms

APA1; ELO3; SRE1; VBM1

Chromosome

XII

fatty acid elongase SUR4
Refseq ID	NP_013476
Protein GI	398366027
UniProt ID	P40319
mRNA ID	NM_001182261
Length	345
MNTTTSTVIAAVADQFQSLNSSSSCFLKVHVPSIENPFGIELWPIFSKVFEYFSGYPAEQFEFIHNKTFLANGYHAVSIIIVYYIIIFGGQAILRALNASPLKFKLLFEIHNLFLTSISLVLWLLMLEQLVPMVYHNGLFWSICSKEAFAPKLVTLYYLNYLTKFVELIDTVFLVLRRKKLLFLHTYHHGATALLCYTQLIGRTSVEWVVILLNLGVHVIMYWYYFLSSCGIRVWWKQWVTRFQIIQFLIDLVFVYFATYTFYAHKYLDGILPNKGTCYGTQAAAAYGYLILTSYLLLFISFYIQSYKKGGKKTVKKESEVSGSVASGSSTGVKTSNTKVSSRKA

Entrez Gene ID

851087

Gene Name

fatty acid elongase SUR4

Gene Symbol

SUR4

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005783	IDA:SGD	C	endoplasmic reticulum
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0009922	IMP:SGD	F	fatty acid elongase activity
GO:0006633	IMP:SGD	P	fatty acid biosynthetic process
GO:0030497	IMP:SGD	P	fatty acid elongation
GO:0006892	IGI:SGD	P	post-Golgi vesicle-mediated transport
GO:0030148	IMP:SGD	P	sphingolipid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID	Description
sce01110	Biosynthesis of secondary metabolites
ko01040	Biosynthesis of unsaturated fatty acids
sce01040	Biosynthesis of unsaturated fatty acids
M00415	Fatty acid biosynthesis, elongation, endoplasmic reticulum
sce_M00415	Fatty acid biosynthesis, elongation, endoplasmic reticulum
ko00062	Fatty acid elongation
sce00062	Fatty acid elongation
ko01212	Fatty acid metabolism
sce01212	Fatty acid metabolism
sce01100	Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
PWY-7036	very long chain fatty acid biosynthesis II

REACTOME Pathway Links

REACTOME Pathway ID	Description
5618114	Fatty Acyl-CoA Biosynthesis
5618090	Fatty acid, triacylglycerol, and ketone body metabolism
5618023	Metabolism
5618091	Metabolism of lipids and lipoproteins
5618123	Synthesis of very long-chain fatty acyl-CoAs
5618115	Triglyceride Biosynthesis

InterPro Annotations

Accession	Description
IPR002076	ELO family

Entry Information

Gene Name

fatty acid elongase SUR4

Protein Entry

ELO3_YEAST

UniProt ID

P40319

Species

Yeast (S288c)

Comments

Comment Type	Description
Catalytic Activity	A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2)
Catalytic Activity	A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2). {ECO:0000269\|PubMed:12684876}.
Domain	The C-terminal di-lysine motifs may confer endoplasmic reticulum localization
Domain	The C-terminal di-lysine motifs may confer endoplasmic reticulum localization. {ECO:0000303\|PubMed:9832547}.
Function	Component of a microsomal membrane bound long-chain fatty acid elongation system, which produces the 20-26-carbon very long-chain fatty acids (VLCFA) from long-chain fatty acid precursors and is involved ceramide and inositol sphingolipid biosynthesis. Component of elongase III, which synthesizes 20-26- carbon fatty acids from 18-carbon-fatty acyl-CoA primers such as stearoyl-CoA by incorporation of malonyl-CoA (PubMed:9211877, PubMed:12684876). Affects plasma membrane H(+)-ATPase activity. May act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1, HXT3 and SNF3 (PubMed:8027068). {ECO:0000269\|PubMed:12684876, ECO:0000269\|PubMed:8027068, ECO:0000269\|PubMed:9211877}.
Similarity	Belongs to the ELO family
Similarity	Belongs to the ELO family. {ECO:0000305}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269\|PubMed:12087109, ECO:0000269\|PubMed:14562095, ECO:0000269\|PubMed:9832547}; Multi-pass membrane protein .
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269\|PubMed:12087109, ECO:0000269\|PubMed:14562095, ECO:0000269\|PubMed:9832547}; Multi-pass membrane protein {ECO:0000305}.