Gene/Proteome Database (LMPD)

LMPD ID
LMP007247
Gene ID
851558
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
type 2C protein phosphatase PTC1
Gene Symbol
PTC1
Synonyms
CWH47; KCS2; TPD1
Chromosome
IV
EC Number
3.1.3.16;

Proteins

type 2C protein phosphatase PTC1
Refseq ID NP_010278
Protein GI 398364893
UniProt ID P35182
mRNA ID NM_001180065
Length 281
MSNHSEILERPETPYDITYRVGVAENKNSKFRRTMEDVHTYVKNFASRLDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNILADETRDVRDVLNDSFLAIDEEINTKLVGNSGCTAAVCVLRWELPDSVSDDSMDLAQHQRKLYTANVGDSRIVLFRNGNSIRLTYDHKASDTLEMQRVEQAGGLIMKSRVNGMLAVTRSLGDKFFDSLVVGSPFTTSVEITSEDKFLILACDGLWDVIDDQDACELIKDITEPNEAAKVLVRYALENGTTDNVTVMVVFL

Gene Information

Entrez Gene ID
851558
Gene Name
type 2C protein phosphatase PTC1
Gene Symbol
PTC1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:SGD C cytoplasm
GO:0005634 IDA:SGD C nucleus
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004722 IDA:SGD F protein serine/threonine phosphatase activity
GO:0000173 IDA:SGD P inactivation of MAPK activity involved in osmosensory signaling pathway
GO:0000001 IMP:SGD P mitochondrion inheritance
GO:0000750 IMP:SGD P pheromone-dependent signal transduction involved in conjugation with cellular fusion
GO:0006470 IDA:SGD P protein dephosphorylation
GO:0006950 IEA:UniProtKB-KW P response to stress
GO:0006388 IMP:SGD P tRNA splicing, via endonucleolytic cleavage and ligation

Domain Information

InterPro Annotations

Accession Description
IPR015655 Protein phosphatase 2C
IPR001932 Protein phosphatase 2C (PP2C)-like domain
IPR000222 Protein phosphatase 2C, manganese/magnesium aspartate binding site

UniProt Annotations

Entry Information

Gene Name
type 2C protein phosphatase PTC1
Protein Entry
PP2C1_YEAST
UniProt ID
P35182
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium or manganese ions per subunit. Manganese is about 20 times more efficient than magnesium.;
Function It has a serine and a weak tyrosine phosphatase activity with ratios of serine to tyrosine phosphatase activity as high as 200:1. It is essential for growth or germination at 37 degrees Celsius. May have a role in the heat shock response. Involved in tRNA splicing and cell separation.
Interaction Q12163:NBP2; NbExp=4; IntAct=EBI-12784, EBI-34713;
Miscellaneous Present with 1520 molecules/cell in log phase SD medium
Miscellaneous Present with 1520 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the PP2C family
Similarity Belongs to the PP2C family. {ECO:0000305}.
Subunit Interacts with NBP2 and PBS2
Subunit Interacts with NBP2 and PBS2. {ECO:0000269|PubMed:14685261}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007247 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398364893 RefSeq NP_010278 281 type 2C protein phosphatase PTC1

Identical Sequences to LMP007247 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007247 proteins

Reference Database Accession Length Protein Name