Gene/Proteome Database (LMPD)

LMPD ID
LMP007262
Gene ID
851753
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
inositol polyphosphate multikinase
Gene Symbol
ARG82
Synonyms
ARGR3; IPK2
Alternate Names
inositol polyphosphate multikinase
Chromosome
IV
EC Number
2.7.1.151

Proteins

inositol polyphosphate multikinase
Refseq ID NP_010458
Protein GI 398365957
UniProt ID P07250
mRNA ID NM_001180480
Length 355
RefSeq Status PROVISIONAL
MDTVNNYRVLEHKAAGHDGTLTDGDGLLIFKPAFPQELEFYKAIQVRDVSRRKSSADGDAPLCSWMPTYLGVLNEGAKIEQSGDAALLKIDERLSDSTDNLDSIPVKSEKSKQYLVLENLLYGFSKPNILDIKLGKTLYDSKASLEKRERMKRVSETTTSGSLGFRICGMKIQKNPSVLNQLSLEYYEEEADSDYIFINKLYGRSRTDQNVSDAIELYFNNPHLSDARKHQLKKTFLKRLQLFYNTMLEEEVRMISSSLLFIYEGDPERWELLNDVDKLMRDDFIDDDDDDDDNDDDDDDDAEGSSEGPKDKKTTGSLSSMSLIDFAHSEITPGKGYDENVIEGVETLLDIFMKF

Gene Information

Entrez Gene ID
851753
Gene Name
inositol polyphosphate multikinase
Gene Symbol
ARG82
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IDA:SGD C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0000827 IDA:SGD F inositol-1,3,4,5,6-pentakisphosphate kinase activity
GO:0008440 IMP:SGD F inositol-1,4,5-trisphosphate 3-kinase activity
GO:0000823 IDA:SGD F inositol-1,4,5-trisphosphate 6-kinase activity
GO:0000824 IDA:SGD F inositol tetrakisphosphate 3-kinase activity
GO:0000825 IDA:SGD F inositol tetrakisphosphate 6-kinase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0035004 IDA:SGD F phosphatidylinositol 3-kinase activity
GO:0030674 IMP:SGD F protein binding, bridging
GO:0006525 IEA:UniProtKB-KW P arginine metabolic process
GO:0032958 IDA:SGD P inositol phosphate biosynthetic process
GO:0000122 IMP:SGD P negative regulation of transcription from RNA polymerase II promoter
GO:0046854 IDA:SGD P phosphatidylinositol phosphorylation
GO:0045944 IMP:SGD P positive regulation of transcription from RNA polymerase II promoter
GO:0050821 IMP:SGD P protein stabilization
GO:0000821 IMP:SGD P regulation of arginine metabolic process
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
sce00562 Inositol phosphate metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6361 1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)
PWY3O-402 inositol phosphate biosynthesis
PWY-6369 inositol pyrophosphates biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR005522 Inositol polyphosphate kinase

UniProt Annotations

Entry Information

Gene Name
inositol polyphosphate multikinase
Protein Entry
IPMK_YEAST
UniProt ID
P07250
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Function Has kinase activity and phosphorylates inositol 1,4,5- trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,5- tetrakisphosphate (Ins(1,3,4,5)P4). Has low kinase activity towards InsP6. With ARG80, ARG81 and MCM1, coordinates the expression of arginine anabolic and catabolic genes in response to arginine. Recruites ARG80 and MCM21 to stabilize them. {ECO:0000269|PubMed:10574768, ECO:0000269|PubMed:10632874}.
Miscellaneous Present with 2720 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Miscellaneous The expression of this protein is not effected by the presence of arginine.
Similarity Belongs to the inositol phosphokinase (IPK) family. {ECO:0000305}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10632874}.
Subunit Interacts with ARG80 and MCM1. {ECO:0000269|PubMed:10632874, ECO:0000269|PubMed:17050532}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007262 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398365957 RefSeq NP_010458 355 inositol polyphosphate multikinase

Identical Sequences to LMP007262 proteins

Reference Database Accession Length Protein Name
GI:398365957 GenBank EDV08139.1 355 inositol polyphosphate multikinase [Saccharomyces cerevisiae RM11-1a]
GI:398365957 GenBank EEU07821.1 355 Arg82p [Saccharomyces cerevisiae JAY291]
GI:398365957 GenBank EGA87479.1 355 Arg82p [Saccharomyces cerevisiae VL3]
GI:398365957 GenBank EWG97128.1 355 Arg82p [Saccharomyces cerevisiae R103]
GI:398365957 gnl McCuskerlabDuke 355 Arg82p [Saccharomyces cerevisiae YJM993]
GI:398365957 Third Party Genbank DAA12015.1 355 TPA: inositol polyphosphate multikinase [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007262 proteins

Reference Database Accession Length Protein Name
GI:398365957 GenBank AAS56022.1 355 YDR173C [Saccharomyces cerevisiae]
GI:398365957 GenBank EGA75457.1 376 Arg82p [Saccharomyces cerevisiae AWRI796]
GI:398365957 PDB 2IEW 363 Chain A, Crystal Structure Of Inositol Phosphate Multikinase Ipk2 From S. Cerevisiae
GI:398365957 PDB 2IEW 363 Chain B, Crystal Structure Of Inositol Phosphate Multikinase Ipk2 From S. Cerevisiae
GI:398365957 PDB 2IF8 363 Chain A, Crystal Structure Of Inositol Phosphate Multikinase Ipk2 In Complex With Adp And Mn2+ From S. Cerevisiae
GI:398365957 PDB 2IF8 363 Chain B, Crystal Structure Of Inositol Phosphate Multikinase Ipk2 In Complex With Adp And Mn2+ From S. Cerevisiae