LIPID MAPS

LMPD ID

LMP007268

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Scs2p

Gene Symbol

SCS2

Synonyms

-

Chromosome

V

Scs2p
Refseq ID	NP_011046
Protein GI	398364741
UniProt ID	P40075
mRNA ID	NM_001179010
Length	244
MSAVEISPDVLVYKSPLTEQSTEYASISNNSDQTIAFKVKTTAPKFYCVRPNAAVVAPGETIQVQVIFLGLTEEPAADFKCRDKFLVITLPSPYDLNGKAVADVWSDLEAEFKQQAISKKIKVKYLISPDVHPAQNQNIQENKETVEPVVQDSEPKEVPAVVNEKEVPAEPETQPPVQVKKEEVPPVVQKTVPHENEKQTSNSTPAPQNQIKEAATVPAENESSSMGIFILVALLILVLGWFYR

Entrez Gene ID

Gene Name

Scs2p

Gene Symbol

SCS2

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005934	IDA:SGD	C	cellular bud tip
GO:0005783	IDA:SGD	C	endoplasmic reticulum
GO:0030176	IDA:SGD	C	integral component of endoplasmic reticulum membrane
GO:0005635	IDA:SGD	C	nuclear envelope
GO:0031965	IDA:SGD	C	nuclear membrane
GO:0033149	IMP:SGD	F	FFAT motif binding
GO:0035091	IDA:SGD	F	phosphatidylinositol binding
GO:0005198	IEA:InterPro	F	structural molecule activity
GO:0006348	IMP:SGD	P	chromatin silencing at telomere
GO:0048309	IMP:SGD	P	endoplasmic reticulum inheritance
GO:0090158	IGI:SGD	P	endoplasmic reticulum membrane organization
GO:0061163	IDA:SGD	P	endoplasmic reticulum polarization
GO:0042992	IMP:SGD	P	negative regulation of transcription factor import into nucleus
GO:0008654	IMP:SGD	P	phospholipid biosynthetic process
GO:0032377	IMP:SGD	P	regulation of intracellular lipid transport
GO:0060304	IGI:SGD	P	regulation of phosphatidylinositol dephosphorylation

Accession	Description
IPR000535	MSP domain
IPR008962	PapD-like
IPR016763	Vesicle-associated membrane-protein-associated protein

Gene Name

Scs2p

Protein Entry

SCS2_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Domain	The MSP domain is required for binding to the FFAT motif of target proteins.
Function	Targets proteins containing a FFAT motif to endoplasmic reticulum membranes. Regulates phospholipid biosynthesis by modulating the subcellular localization of the transcriptional repressor OPI1. {ECO:0000269\|PubMed:12727870, ECO:0000269\|PubMed:15668246}.
Miscellaneous	Present with 3497 molecules/cell in log phase SD medium
Miscellaneous	Present with 3497 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family
Similarity	Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. {ECO:0000305}.
Similarity	Contains 1 MSP domain. {ECO:0000255\|PROSITE- ProRule:PRU00132}.
Subcellular Location	Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Nucleus membrane; Single-pass type IV membrane protein.
Subunit	Interacts with OPI1. {ECO:0000269\|PubMed:12727870, ECO:0000269\|PubMed:15455074}.