LIPID MAPS

LMPD ID

LMP007299

Gene ID

856261

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

lysophosphatidic acid acyltransferase LOA1

Gene Symbol

LOA1

Synonyms

VPS66

Chromosome

XVI

EC Number

2.3.1.51

lysophosphatidic acid acyltransferase LOA1
Refseq ID	NP_015465
Protein GI	6325397
UniProt ID	Q06508
mRNA ID	NM_001184236
Length	300
MEKYTNWRDNGTGIAPFLPNTIRKPSKVMTACLLGILGVKTIIMLPLIMLYLLTGQNNLLGLILKFTFSWKEEITVQGIKKRDVRKSKHYPQKGKLYICNCTSPLDAFSVVLLAQGPVTLLVPSNDIVYKVSIREFINFILAGGLDIKLYGHEVAELSQLGNTVNFMFAEGTSCNGKSVLPFSITGKKLKEFIDPSITTMNPAMAKTKKFELQTIQIKTNKTAITTLPISNMEYLSRFLNKGINVKCKINEPQVLSDNLEELRVALNGGDKYKLVSRKLDVESKRNFVKEYISDQRKKRK

Entrez Gene ID

856261

Gene Name

lysophosphatidic acid acyltransferase LOA1

Gene Symbol

LOA1

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005783	IDA:SGD	C	endoplasmic reticulum
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0005811	IDA:SGD	C	lipid particle
GO:0003841	IEA:UniProtKB-EC	F	1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0042171	IDA:SGD	F	lysophosphatidic acid acyltransferase activity
GO:0035356	IMP:SGD	P	cellular triglyceride homeostasis
GO:0006629	IEA:UniProtKB-KW	P	lipid metabolic process
GO:0034389	IMP:SGD	P	lipid particle organization

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
PWY-7417	phospholipid remodeling (phosphatidate)
PWY-7417	phospholipid remodeling (phosphatidate, yeast)
PWY-7411	superpathway phosphatidate biosynthesis (yeast)
PWY-7411	superpathway phosphatidate biosynthesis (yeast)

InterPro Annotations

Accession	Description

Entry Information

Gene Name

lysophosphatidic acid acyltransferase LOA1

Protein Entry

LOA1_YEAST

UniProt ID

Q06508

Species

Yeast (S288c)

Comments

Comment Type	Description
Catalytic Activity	Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
Catalytic Activity	Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. {ECO:0000269\|PubMed:22090344}.
Function	Acyl-CoA-dependent lysophosphatidic acid acyltransferase with preference for oleoyl-CoA. Involved in triacylglyceride homeostasis and lipid droplet formation. Involved in vacuolar protein sorting. {ECO:0000269\|PubMed:12134085, ECO:0000269\|PubMed:22090344}.
Miscellaneous	Present with 6630 molecules/cell in log phase SD medium
Miscellaneous	Present with 6630 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
Similarity	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}.
Subcellular Location	Lipid droplet {ECO:0000269\|PubMed:21820081, ECO:0000269\|PubMed:22090344}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein . Note=Lipid droplets consist of a surface phospholipid monolayer and a hydrophobic interior. The latter makes embedding of proteins containing transmembrane segments difficult, and these may instead adopt a hairpin or monotonic conformation when associated with lipid droplet membranes. Always localizes to lipid droplets, irrespective of whether cells are grown on glucose or oleate.
Subcellular Location	Lipid droplet {ECO:0000269\|PubMed:21820081, ECO:0000269\|PubMed:22090344}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Lipid droplets consist of a surface phospholipid monolayer and a hydrophobic interior. The latter makes embedding of proteins containing transmembrane segments difficult, and these may instead adopt a hairpin or monotonic conformation when associated with lipid droplet membranes. Always localizes to lipid droplets, irrespective of whether cells are grown on glucose or oleate.