Gene/Proteome Database (LMPD)

LMPD ID
LMP007304
Gene ID
855679
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
alpha-1,2-mannosyltransferase ALG11
Gene Symbol
ALG11
Synonyms
-
Alternate Names
alpha-1,2-mannosyltransferase ALG11
Chromosome
XIV
EC Number
2.4.1.131

Proteins

alpha-1,2-mannosyltransferase ALG11
Refseq ID NP_014350
Protein GI 6324280
UniProt ID P53954
mRNA ID NM_001182887
Length 548
RefSeq Status PROVISIONAL
MGSAWTNYNFEEVKSHFGFKKYVVSSLVLVYGLIKVLTWIFRQWVYSSLNPFSKKSSLLNRAVASCGEKNVKVFGFFHPYCNAGGGGEKVLWKAVDITLRKDAKNVIVIYSGDFVNGENVTPENILNNVKAKFDYDLDSDRIFFISLKLRYLVDSSTWKHFTLIGQAIGSMILAFESIIQCPPDIWIDTMGYPFSYPIIARFLRRIPIVTYTHYPIMSKDMLNKLFKMPKKGIKVYGKILYWKVFMLIYQSIGSKIDIVITNSTWTNNHIKQIWQSNTCKIIYPPCSTEKLVDWKQKFGTAKGERLNQAIVLAQFRPEKRHKLIIESFATFLKNLPDSVSPIKLIMAGSTRSKQDENYVKSLQDWSENVLKIPKHLISFEKNLPFDKIEILLNKSTFGVNAMWNEHFGIAVVEYMASGLIPIVHASAGPLLDIVTPWDANGNIGKAPPQWELQKKYFAKLEDDGETTGFFFKEPSDPDYNTTKDPLRYPNLSDLFLQITKLDYDCLRVMGARNQQYSLYKFSDLKFDKDWENFVLNPICKLLEEEERG

Gene Information

Entrez Gene ID
855679
Gene Name
alpha-1,2-mannosyltransferase ALG11
Gene Symbol
ALG11
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IDA:SGD C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0004377 IEA:UniProtKB-EC F GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
GO:0000026 IDA:SGD F alpha-1,2-mannosyltransferase activity
GO:0097502 IDA:GOC P mannosylation
GO:0006490 IDA:SGD P oligosaccharide-lipid intermediate biosynthetic process
GO:0006486 IGI:SGD P protein glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
sce00510 N-Glycan biosynthesis
sce_M00055 N-glycan precursor biosynthesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS dolichyl-diphosphooligosaccharide biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001296 Glycosyl transferase, family 1

UniProt Annotations

Entry Information

Gene Name
alpha-1,2-mannosyltransferase ALG11
Protein Entry
ALG11_YEAST
UniProt ID
P53954
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity 2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D- Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc- diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)- D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D- GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol. {ECO:0000269|PubMed:16878994, ECO:0000269|PubMed:19929855}.
Function Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP- dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. {ECO:0000269|PubMed:11278778, ECO:0000269|PubMed:16878994, ECO:0000269|PubMed:19929855}.
Interaction P16661:ALG1; NbExp=2; IntAct=EBI-2497, EBI-2206309;
Miscellaneous Present with 3140 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:11278778}; Single-pass type II membrane protein {ECO:0000269|PubMed:11278778}.
Subunit Interacts with ALG1. {ECO:0000269|PubMed:15044395}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007304 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6324280 RefSeq NP_014350 548 alpha-1,2-mannosyltransferase ALG11

Identical Sequences to LMP007304 proteins

Reference Database Accession Length Protein Name
GI:6324280 EMBL CAY82553.1 548 Alg11p [Saccharomyces cerevisiae EC1118]
GI:6324280 GenBank AAB49937.1 548 Alg11p [Saccharomyces cerevisiae]
GI:6324280 GenBank EEU08230.1 548 Alg11p [Saccharomyces cerevisiae JAY291]
GI:6324280 GenBank EIW08044.1 548 Alg11p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6324280 SwissProt P53954.1 548 RecName: Full=GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; AltName: Full=Alpha-1,2-mannosyltransferase ALG11; AltName: Full=Asparagine-linked glycosylation protein 11; AltName: Full=Glycolipid 2-alpha-mannosyltransferase [Saccharomyces cerevisiae S288c]
GI:6324280 Third Party Genbank DAA10497.1 548 TPA: alpha-1,2-mannosyltransferase ALG11 [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007304 proteins

Reference Database Accession Length Protein Name
GI:6324280 GenBank EDN62762.1 548 asparagine-linked glycosylation protein [Saccharomyces cerevisiae YJM789]
GI:6324280 GenBank EGA73394.1 548 Alg11p [Saccharomyces cerevisiae AWRI796]
GI:6324280 GenBank EGA85092.1 548 Alg11p [Saccharomyces cerevisiae VL3]
GI:6324280 GenBank EWG89178.1 548 Alg11p [Saccharomyces cerevisiae P301]
GI:6324280 GenBank EWH16204.1 548 Alg11p [Saccharomyces cerevisiae P283]
GI:6324280 gnl McCuskerlabDuke 548 Alg11p [Saccharomyces cerevisiae YJM993]