Gene/Proteome Database (LMPD)

LMPD ID
LMP007310
Gene ID
851606
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Ehd3p
Gene Symbol
EHD3
Synonyms
-
Alternate Names
Ehd3p
Chromosome
IV
EC Number
3.1.2.4

Proteins

Ehd3p
Refseq ID NP_010321
Protein GI 6320241
UniProt ID P28817
mRNA ID NM_001180344
Length 500
RefSeq Status PROVISIONAL
MLRNTLKCAQLSSKYGFKTTTRTFMTTQPQLNVTDAPPVLFTVQDTARVITLNRPKKLNALNAEMSESMFKTLNEYAKSDTTNLVILKSSNRPRSFCAGGDVATVAIFNFNKEFAKSIKFFTDEYSLNFQIATYLKPIVTFMDGITMGGGVGLSIHTPFRIATENTKWAMPEMDIGFFPDVGSTFALPRIVTLANSNSQMALYLCLTGEVVTGADAYMLGLASHYVSSENLDALQKRLGEISPPFNNDPQSAYFFGMVNESIDEFVSPLPKDYVFKYSNEKLNVIEACFNLSKNGTIEDIMNNLRQYEGSAEGKAFAQEIKTKLLTKSPSSLQIALRLVQENSRDHIESAIKRDLYTAANMCMNQDSLVEFSEATKHKLIDKQRVPYPWTKKEQLFVSQLTSITSPKPSLPMSLLRNTSNVTWTQYPYHSKYQLPTEQEIAAYIEKRTNDDTGAKVTEREVLNHFANVIPSRRGKLGIQSLCKIVCERKCEEVNDGLRWK

Gene Information

Entrez Gene ID
851606
Gene Name
Ehd3p
Gene Symbol
EHD3
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:SGD C mitochondrion
GO:0003860 IDA:SGD F 3-hydroxyisobutyryl-CoA hydrolase activity
GO:0006574 IEA:UniProtKB-UniPathway P valine catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
sce01200 Carbon metabolism
sce01100 Metabolic pathways
sce00640 Propanoate metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5618049 Branched-chain amino acid catabolism

Domain Information

InterPro Annotations

Accession Description
IPR029045 ClpP/crotonase-like domain
IPR001753 Crotonase_core_superfam
IPR018376 Enoyl-CoA hydratase/isomerase, conserved site

UniProt Annotations

Entry Information

Gene Name
Ehd3p
Protein Entry
HIBCH_YEAST
UniProt ID
P28817
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity 3-hydroxy-2-methylpropanoyl-CoA + H(2)O = CoA + 3-hydroxy-2-methylpropanoate. {ECO:0000269|PubMed:12697341}.
Function Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity). Has an indirect role in endocytic membrane trafficking. May have a function in protein biosynthesis in mitochondrial small ribosomal subunit. {ECO:0000250, ECO:0000269|PubMed:11378903, ECO:0000269|PubMed:14566057}.
Miscellaneous Present with 3950 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Amino-acid degradation; L-valine degradation.
Similarity Belongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:16823961}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007310 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6320241 RefSeq NP_010321 500 Ehd3p

Identical Sequences to LMP007310 proteins

Reference Database Accession Length Protein Name
GI:6320241 GenBank ADT55021.1 500 Sequence 148 from patent US 7842852
GI:6320241 GenBank EGA87620.1 500 Ehd3p [Saccharomyces cerevisiae VL3]
GI:6320241 GenBank EWG87096.1 500 Ehd3p [Saccharomyces cerevisiae R008]
GI:6320241 GenBank EWG91795.1 500 Ehd3p [Saccharomyces cerevisiae P301]
GI:6320241 GenBank EWG97017.1 500 Ehd3p [Saccharomyces cerevisiae R103]
GI:6320241 gnl McCuskerlabDuke 500 Ehd3p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP007310 proteins

Reference Database Accession Length Protein Name
GI:6320241 DBBJ GAA22274.1 500 K7_Ehd3p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6320241 GenBank AAU09686.1 500 YDR036C [Saccharomyces cerevisiae]
GI:6320241 GenBank EEU07108.1 500 Ehd3p [Saccharomyces cerevisiae JAY291]
GI:6320241 GenBank EGA59332.1 476 Ehd3p [Saccharomyces cerevisiae FostersB]
GI:6320241 GenBank EGA62722.1 500 Ehd3p [Saccharomyces cerevisiae FostersO]
GI:6320241 GenBank EHN08040.1 476 Ehd3p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]