LIPID MAPS

LMPD ID

LMP007317

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Pil1p

Gene Symbol

PIL1

Synonyms

-

Chromosome

VII

Pil1p
Refseq ID	NP_011600
Protein GI	398365595
UniProt ID	P53252
mRNA ID	NM_001181215
Length	339
MHRTYSLRNSRAPTASQLQNPPPPPSTTKGRFFGKGGLAYSFRRSAAGAFGPELSRKLSQLVKIEKNVLRSMELTANERRDAAKQLSIWGLENDDDVSDITDKLGVLIYEVSELDDQFIDRYDQYRLTLKSIRDIEGSVQPSRDRKDKITDKIAYLKYKDPQSPKIEVLEQELVRAEAESLVAEAQLSNITRSKLRAAFNYQFDSIIEHSEKIALIAGYGKALLELLDDSPVTPGETRPAYDGYEASKQIIIDAESALNEWTLDSAQVKPTLSFKQDYEDFEPEEGEEEEEEDGQGRWSEDEQEDGQIEEPEQEEEGAVEEHEQVGHQQSESLPQQTTA

Entrez Gene ID

Gene Name

Pil1p

Gene Symbol

PIL1

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0032126	IDA:SGD	C	eisosome
GO:0005811	IEA:UniProtKB-KW	C	lipid particle
GO:0008289	IDA:SGD	F	lipid binding
GO:0070941	IMP:SGD	P	eisosome assembly
GO:0006897	IMP:SGD	P	endocytosis
GO:0006469	IMP:SGD	P	negative regulation of protein kinase activity
GO:0008104	IMP:SGD	P	protein localization
GO:0009408	IMP:SGD	P	response to heat

Accession	Description
IPR028245	PIL1/LSP1

Gene Name

Pil1p

Protein Entry

PIL1_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Function	Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress
Function	Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress. {ECO:0000269\|PubMed:15016821}.
Interaction	P35719:MRP8; NbExp=3; IntAct=EBI-23225, EBI-16255;
Miscellaneous	Present with 2157 molecules/cell in log phase SD medium
Miscellaneous	Present with 2157 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Ptm	Phosphorylated by PKH1 and PKH2. Phosphorylation is inhibited by sphingolipid long chain bases (LCBs). {ECO:0000269\|PubMed:15016821, ECO:0000269\|PubMed:15665377, ECO:0000269\|PubMed:17330950, ECO:0000269\|PubMed:17761666, ECO:0000269\|PubMed:18407956, ECO:0000269\|PubMed:19779198}.
Subcellular Location	Lipid droplet .
Subcellular Location	Lipid droplet {ECO:0000269\|PubMed:14562095}.