Gene/Proteome Database (LMPD)

LMPD ID
LMP007356
Gene ID
852550
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
imidazoleglycerol-phosphate synthase
Gene Symbol
HIS7
Synonyms
-
Chromosome
II
EC Number
2.4.2.-

Proteins

imidazoleglycerol-phosphate synthase
Refseq ID NP_009807
Protein GI 398365721
UniProt ID P33734
mRNA ID NM_001178596
Length 552
MPVVHVIDVESGNLQSLTNAIEHLGYEVQLVKSPKDFNISGTSRLILPGVGNYGHFVDNLFNRGFEKPIREYIESGKPIMGICVGLQALFAGSVESPKSTGLNYIDFKLSRFDDSEKPVPEIGWNSCIPSENLFFGLDPYKRYYFVHSFAAILNSEKKKNLENDGWKIAKAKYGSEEFIAAVNKNNIFATQFHPEKSGKAGLNVIENFLKQQSPPIPNYSAEEKELLMNDYSNYGLTRRIIACLDVRTNDQGDLVVTKGDQYDVREKSDGKGVRNLGKPVQLAQKYYQQGADEVTFLNITSFRDCPLKDTPMLEVLKQAAKTVFVPLTVGGGIKDIVDVDGTKIPALEVASLYFRSGADKVSIGTDAVYAAEKYYELGNRGDGTSPIETISKAYGAQAVVISVDPKRVYVNSQADTKNKVFETEYPGPNGEKYCWYQCTIKGGRESRDLGVWELTRACEALGAGEILLNCIDKDGSNSGYDLELIEHVKDAVKIPVIASSGAGVPEHFEEAFLKTRADACLGAGMFHRGEFTVNDVKEYLLEHGLKVRMDEE

Gene Information

Entrez Gene ID
852550
Gene Name
imidazoleglycerol-phosphate synthase
Gene Symbol
HIS7
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:InterPro C cytoplasm
GO:0005622 TAS:SGD C intracellular
GO:0004359 IDA:SGD F glutaminase activity
GO:0000107 IDA:SGD F imidazoleglycerol-phosphate synthase activity
GO:0016833 IEA:InterPro F oxo-acid-lyase activity
GO:0006541 IEA:UniProtKB-KW P glutamine metabolic process
GO:0000105 IMP:SGD P histidine biosynthetic process
GO:0006950 IEA:UniProtKB-KW P response to stress

KEGG Pathway Links

KEGG Pathway ID Description
ko01230 Biosynthesis of amino acids
sce01230 Biosynthesis of amino acids
sce01110 Biosynthesis of secondary metabolites
M00026 Histidine biosynthesis, PRPP => histidine
sce_M00026 Histidine biosynthesis, PRPP => histidine
ko00340 Histidine metabolism
sce00340 Histidine metabolism
sce01100 Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID Description
HISTSYN-PWY histidine biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR013785 Aldolase-type TIM barrel
IPR029062 Class I glutamine amidotransferase-like
IPR017926 Glutamine amidotransferase
IPR006062 Histidine biosynthesis
IPR004651 Histidine biosynthesis, HisF
IPR014640 Imidazole glycerol phosphate synthase HisHF
IPR010139 Imidazole glycerol phosphate synthase, subunit H
IPR011060 Ribulose-phosphate binding barrel

UniProt Annotations

Entry Information

Gene Name
imidazoleglycerol-phosphate synthase
Protein Entry
HIS5_YEAST
UniProt ID
P33734
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity 5-[(5-phospho-1-deoxyribulos-1- ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4- carboxamide + L-glutamine = imidazole-glycerol phosphate + 5- aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H(2)O.
Function IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutamine amidotransferase domain provides the ammonia necessary to the cyclase domain to produce IGP and AICAR from PRFAR.
Induction By amino acid starvation. It has a GCN4-dependent and a GCN4-independent (basal) expression.
Miscellaneous Present with 11800 molecules/cell in log phase SD medium
Miscellaneous Present with 11800 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Amino-acid biosynthesis; L-histidine biosynthesis; L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.
Similarity Contains 1 glutamine amidotransferase type-1 domain
Similarity Contains 1 glutamine amidotransferase type-1 domain. {ECO:0000305}.
Similarity In the C-terminal section; belongs to the HisA/HisF family
Similarity In the C-terminal section; belongs to the HisA/HisF family. {ECO:0000305}.
Subunit Monomer. {ECO:0000269|PubMed:11591353, ECO:0000269|PubMed:12795595}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007356 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398365721 RefSeq NP_009807 552 imidazoleglycerol-phosphate synthase

Identical Sequences to LMP007356 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007356 proteins

Reference Database Accession Length Protein Name