Gene/Proteome Database (LMPD)

LMPD ID
LMP007359
Gene ID
855127
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Srt1p
Gene Symbol
SRT1
Synonyms
-
Alternate Names
Srt1p
Chromosome
XIII
EC Number
2.5.1.87

Proteins

Srt1p
Refseq ID NP_013819
Protein GI 6323748
UniProt ID Q03175
mRNA ID NM_001182601
Length 343
RefSeq Status PROVISIONAL
MKMPSIIQIQFVALKRLLVETKEQMCFAVKSIFQRVFAWVMSLSLFSWFYVNLQNILIKALRVGPVPEHVSFIMDGNRRYAKSRRLPVKKGHEAGGLTLLTLLYICKRLGVKCVSAYAFSIENFNRPKEEVDTLMNLFTVKLDEFAKRAKDYKDPLYGSKIRIVGDQSLLSPEMRKKIKKVEEITQDGDDFTLFICFPYTSRNDMLHTIRDSVEDHLENKSPRINIRKFTNKMYMGFHSNKCELLIRTSGHRRLSDYMLWQVHENATIEFSDTLWPNFSFFAMYLMILKWSFFSTIQKYNEKNHSLFEKIHESVPSIFKKKKTAMSLYNFPNPPISVSVTGDE

Gene Information

Entrez Gene ID
855127
Gene Name
Srt1p
Gene Symbol
SRT1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005811 IDA:SGD C lipid particle
GO:0045547 IDA:SGD F dehydrodolichyl diphosphate synthase activity
GO:0004659 IDA:SGD F prenyltransferase activity
GO:0006486 IDA:SGD P protein glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
sce01110 Biosynthesis of secondary metabolites
ko00900 Terpenoid backbone biosynthesis
sce00900 Terpenoid backbone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5618347 Synthesis of Dolichyl-phosphate

Domain Information

InterPro Annotations

Accession Description
IPR001441 Decaprenyl diphosphate synthase-like
IPR018520 Di-trans-poly-cis-decaprenylcistransferase-like, conserved site

UniProt Annotations

Entry Information

Gene Name
Srt1p
Protein Entry
SRT1_YEAST
UniProt ID
Q03175
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity (2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + ditrans,polycis-polyprenyl diphosphate (n = 10-55). {ECO:0000303|PubMed:25066056}.
Function With NUS1, forms the dehydrodolichyl diphosphate syntase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). {ECO:0000269|PubMed:11442630, ECO:0000269|PubMed:17345630, ECO:0000269|PubMed:25066056}.
Induction Expression is induced in the stationary phase. {ECO:0000269|PubMed:11442630}.
Pathway Protein modification; protein glycosylation. {ECO:0000305}.
Similarity Belongs to the UPP synthase family. {ECO:0000305}.
Subcellular Location Lipid droplet {ECO:0000269|PubMed:11442630}.
Subunit Forms an active dehydrodolichyl diphosphate syntase complex with NUS1. {ECO:0000303|PubMed:25066056}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007359 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6323748 RefSeq NP_013819 343 Srt1p

Identical Sequences to LMP007359 proteins

Reference Database Accession Length Protein Name
GI:6323748 DBBJ GAA25542.1 343 K7_Srt1p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6323748 EMBL CBX84094.1 343 unnamed protein product [Saccharomyces cerevisiae]
GI:6323748 GenBank AED37646.1 343 Sequence 28 from patent US 7880058
GI:6323748 GenBank EWH16709.1 343 Srt1p [Saccharomyces cerevisiae P283]
GI:6323748 gnl McCuskerlabDuke 343 Srt1p [Saccharomyces cerevisiae YJM993]
GI:6323748 Third Party Genbank DAA09998.1 343 TPA: Srt1p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007359 proteins

Reference Database Accession Length Protein Name
GI:6323748 EMBL CAY81919.1 343 Srt1p [Saccharomyces cerevisiae EC1118]
GI:6323748 GenBank EGA77568.1 343 Srt1p [Saccharomyces cerevisiae Vin13]
GI:6323748 GenBank EGA81459.1 342 Srt1p [Saccharomyces cerevisiae Lalvin QA23]
GI:6323748 GenBank EHN05349.1 343 Srt1p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6323748 GenBank EIW08362.1 343 Srt1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6323748 GenBank EWG84023.1 342 Srt1p [Saccharomyces cerevisiae R008]