LIPID MAPS

LMPD ID

LMP007373

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

ketoreductase

Gene Symbol

IFA38

Synonyms

-

Chromosome

II

EC Number

1.1.1.330

ketoreductase
Refseq ID	NP_009717
Protein GI	6319635
UniProt ID	P38286
mRNA ID	NM_001178507
Length	347
MTFMQQLQEAGERFRCINGLLWVVFGLGVLKCTTLSLRFLALIFDLFLLPAVNFDKYGAKTGKYCAITGASDGIGKEFARQMAKRGFNLVLISRTQSKLEALQKELEDQHHVVVKILAIDIAEDKESNYESIKELCAQLPITVLVNNVGQSHSIPVPFLETEEKELRNIITINNTATLLITQIIAPKIVETVKAENKKSGTRGLILTMGSFGGLIPTPLLATYSGSKSFLQGWSNSLAGELSKDAIDVELIISYLVTSSMSKIRRSSLMIPNPQQFVKSTLRSVGRRCGSQERYATMTPYWAHAVYQFVITETFGVYSKIVNSINYSFHKSIRIRALKKAARQVKKE

Entrez Gene ID

Gene Name

ketoreductase

Gene Symbol

IFA38

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005783	IDA:SGD	C	endoplasmic reticulum
GO:0005789	IDA:SGD	C	endoplasmic reticulum membrane
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0045703	IMP:SGD	F	ketoreductase activity
GO:0030497	IMP:SGD	P	fatty acid elongation
GO:0030148	IMP:SGD	P	sphingolipid biosynthetic process
GO:0042761	IMP:SGD	P	very long-chain fatty acid biosynthetic process

KEGG Pathway ID	Description
sce01110	Biosynthesis of secondary metabolites
ko01040	Biosynthesis of unsaturated fatty acids
sce01040	Biosynthesis of unsaturated fatty acids
M00415	Fatty acid biosynthesis, elongation, endoplasmic reticulum
sce_M00415	Fatty acid biosynthesis, elongation, endoplasmic reticulum
ko00062	Fatty acid elongation
sce00062	Fatty acid elongation
ko01212	Fatty acid metabolism
sce01212	Fatty acid metabolism
sce01100	Metabolic pathways

BIOCYC Pathway ID	Description
PWY-7036	very long chain fatty acid biosynthesis II

REACTOME Pathway ID	Description
5618354	Androgen biosynthesis
5618114	Fatty Acyl-CoA Biosynthesis
5618090	Fatty acid, triacylglycerol, and ketone body metabolism
5618023	Metabolism
5618091	Metabolism of lipids and lipoproteins
5618355	Metabolism of steroid hormones and vitamin D
5618123	Synthesis of very long-chain fatty acyl-CoAs
5618115	Triglyceride Biosynthesis

Accession	Description
IPR027533	3_ketoreductase_fungal
IPR002347	Glucose/ribitol dehydrogenase
IPR016040	NAD(P)-binding domain
IPR002198	Short-chain dehydrogenase/reductase SDR
IPR020904	Short-chain dehydrogenase/reductase, conserved site

Gene Name

ketoreductase

Protein Entry

MKAR_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	A very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH
Catalytic Activity	A very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH. {ECO:0000255\|HAMAP-Rule:MF_03107, ECO:0000269\|PubMed:12087109}.
Function	Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. {ECO:0000255\|HAMAP-Rule:MF_03107, ECO:0000269\|PubMed:11792704, ECO:0000269\|PubMed:12087109, ECO:0000269\|PubMed:12684876}.
Miscellaneous	Present with 41900 molecules/cell in log phase SD medium
Miscellaneous	Present with 41900 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the short-chain dehydrogenases/reductases (SDR) family
Similarity	Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000255\|HAMAP-Rule:MF_03107}.
Subcellular Location	Endoplasmic reticulum membrane ; Single-pass membrane protein .
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000255\|HAMAP-Rule:MF_03107}; Single-pass membrane protein {ECO:0000255\|HAMAP-Rule:MF_03107}.
Subunit	Interacts with the fatty acid elongation system components ELO3 and TSC13. {ECO:0000255\|HAMAP-Rule:MF_03107, ECO:0000269\|PubMed:12087109}.