LIPID MAPS

Gene/Proteome Database (LMPD)

LMPD ID

LMP007383

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Tsc3p

Gene Symbol

TSC3

Synonyms

Chromosome

Tsc3p
Refseq ID	NP_116327
Protein GI	398364555
UniProt ID	Q3E790
mRNA ID	NM_001184442
Length	80
MTQHKSSMVYIPTTKEAKRRNGKSEGILNTIEEVVEKLYWTYYIHLPFYLMASFDSFFLHVFFLTIFSLSFFGILKYCFL

Entrez Gene ID

Gene Name

Tsc3p

Gene Symbol

TSC3

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0035339	IDA:UniProtKB	C	SPOTS complex
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0008047	IDA:SGD	F	enzyme activator activity
GO:0006666	IPI:SGD	P	3-keto-sphinganine metabolic process
GO:0043085	IDA:GOC	P	positive regulation of catalytic activity
GO:0030148	IMP:SGD	P	sphingolipid biosynthetic process

Accession	Description

Gene Name

Tsc3p

Protein Entry

TSC3_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Function	Stimulates the activity of serine palmitoyltransferase (SPT).
Subcellular Location	Endoplasmic reticulum membrane ; Single-pass membrane protein {ECO:0000269\|PubMed:10713067, ECO:0000269\|PubMed:14562095}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269\|PubMed:10713067, ECO:0000269\|PubMed:14562095}; Single-pass membrane protein {ECO:0000269\|PubMed:10713067, ECO:0000269\|PubMed:14562095}.
Subunit	Interacts with the serine palmitoyltransferase complex LCB1-LCB2. Component of the SPOTS complex, at least composed of LCB1/2 (LCB1 and/or LCB2), ORM1/2 (ORM1 and/or ORM2), SAC1 and TSC3
Subunit	Interacts with the serine palmitoyltransferase complex LCB1-LCB2. Component of the SPOTS complex, at least composed of LCB1/2 (LCB1 and/or LCB2), ORM1/2 (ORM1 and/or ORM2), SAC1 and TSC3. {ECO:0000269\|PubMed:10713067, ECO:0000269\|PubMed:20182505}.

Protein GI	Database	Accession	Length	Protein Name
398364555	RefSeq	NP_116327	80	Tsc3p

Reference	Database	Accession	Length	Protein Name

Reference	Database	Accession	Length	Protein Name