Gene/Proteome Database (LMPD)

LMPD ID
LMP007475
Gene ID
850990
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
dodecenoyl-CoA isomerase
Gene Symbol
ECI1
Synonyms
-
Alternate Names
dodecenoyl-CoA isomerase
Chromosome
XII
EC Number
5.3.3.8

Proteins

dodecenoyl-CoA isomerase
Refseq ID NP_013386
Protein GI 6323314
UniProt ID Q05871
mRNA ID NM_001182171
Length 280
RefSeq Status PROVISIONAL
MSQEIRQNEKISYRIEGPFFIIHLMNPDNLNALEGEDYIYLGELLELADRNRDVYFTIIQSSGRFFSSGADFKGIAKAQGDDTNKYPSETSKWVSNFVARNVYVTDAFIKHSKVLICCLNGPAIGLSAALVALCDIVYSINDKVYLLYPFANLGLITEGGTTVSLPLKFGTNTTYECLMFNKPFKYDIMCENGFISKNFNMPSSNAEAFNAKVLEELREKVKGLYLPSCLGMKKLLKSNHIDAFNKANSVEVNESLKYWVDGEPLKRFRQLGSKQRKHRL

Gene Information

Entrez Gene ID
850990
Gene Name
dodecenoyl-CoA isomerase
Gene Symbol
ECI1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005777 IDA:SGD C peroxisome
GO:0004165 IDA:SGD F dodecenoyl-CoA delta-isomerase activity
GO:0006635 IDA:SGD P fatty acid beta-oxidation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-7337 10-cis-heptadecenoyl-CoA degradation
PWY-7338 10-trans-heptadecenoyl-CoA degradation (reductase-dependent)
PWY-7340 9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent)
PWY-7307 oleate beta-oxidation (reductase-dependent)

Domain Information

InterPro Annotations

Accession Description
IPR029045 ClpP/crotonase-like domain
IPR001753 Crotonase_core_superfam

UniProt Annotations

Entry Information

Gene Name
dodecenoyl-CoA isomerase
Protein Entry
ECI1_YEAST
UniProt ID
Q05871
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl- CoA.
Function Essential for the beta oxidation of unsaturated fatty acids. {ECO:0000269|PubMed:9837886}.
Induction By oleate. {ECO:0000269|PubMed:9837886}.
Pathway Lipid metabolism; fatty acid beta-oxidation.
Similarity Belongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}.
Subcellular Location Peroxisome {ECO:0000269|PubMed:10381339, ECO:0000269|PubMed:11302517, ECO:0000269|PubMed:9837886}. Note=This location is DCI1 dependent.
Subunit Homohexamer, dimer of trimers. Interacts with DCI1. {ECO:0000269|PubMed:10381339, ECO:0000269|PubMed:10944342, ECO:0000269|PubMed:11399063, ECO:0000269|PubMed:14741345}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007475 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6323314 RefSeq NP_013386 280 dodecenoyl-CoA isomerase

Identical Sequences to LMP007475 proteins

Reference Database Accession Length Protein Name
GI:6323314 EMBL CAY37256.1 280 unnamed protein product [Saccharomyces cerevisiae]
GI:6323314 GenBank AAC83700.1 280 d3,d2-enoyl CoA isomerase ECI1 [Saccharomyces cerevisiae]
GI:6323314 GenBank AAV20298.1 280 Sequence 558 from patent US 6753314
GI:6323314 GenBank EIW08888.1 280 Eci1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6323314 SwissProt Q05871.1 280 RecName: Full=3,2-trans-enoyl-CoA isomerase; AltName: Full=Delta(3),Delta(2)-enoyl-CoA isomerase; Short=D3,D2-enoyl-CoA isomerase; AltName: Full=Dodecenoyl-CoA isomerase [Saccharomyces cerevisiae S288c]
GI:6323314 Third Party Genbank DAA09594.1 280 TPA: dodecenoyl-CoA isomerase [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007475 proteins

Reference Database Accession Length Protein Name
GI:6323314 GenBank EDN59369.1 280 delta3,delta2-enoyl-CoA isomerase [Saccharomyces cerevisiae YJM789]
GI:6323314 GenBank EGA77607.1 280 Eci1p [Saccharomyces cerevisiae Vin13]
GI:6323314 GenBank EGA85682.1 280 Eci1p [Saccharomyces cerevisiae VL3]
GI:6323314 gnl McCuskerlabDuke 280 Eci1p [Saccharomyces cerevisiae YJM993]
GI:6323314 PDB 1PJH 280 Chain A, Structural Studies On Delta3-Delta2-Enoyl-Coa Isomerase: The Variable Mode Of Assembly Of The Trimeric Disks Of The Crotonase Superfamily
GI:6323314 PDB 1PJH 280 Chain B, Structural Studies On Delta3-Delta2-Enoyl-Coa Isomerase: The Variable Mode Of Assembly Of The Trimeric Disks Of The Crotonase Superfamily