Gene/Proteome Database (LMPD)
LMPD ID
LMP007544
Gene ID
Species
Escherichia coli K-12 (E. coli)
Gene Name
D-sedoheptulose 7-phosphate isomerase
Gene Symbol
Synonyms
ECK0223; JW0212; isn; lpcA; tfrA; yafI
Summary
Sedoheptulose 7-phosphate isomerase catalyzes the first committed step in the biosynthesis of a core component of lipopolysaccharide, the isomerization of D-sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate. [More information is available at EcoCyc: G6106].
Orthologs
Proteins
D-sedoheptulose 7-phosphate isomerase [Escherichia coli str. K-12 substr. MG1655] | |
---|---|
Refseq ID | NP_414757 |
Protein GI | 16128208 |
UniProt ID | P63224 |
Length | 192 |
RefSeq Status | REVIEWED |
MYQDLIRNELNEAAETLANFLKDDANIHAIQRAAVLLADSFKAGGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPAIAISDVSHISCVGNDFGFNDIFSRYVEAVGREGDVLLGISTSGNSANVIKAIAAAREKGMKVITLTGKDGGKMAGTADIEIRVPHFGYADRIQEIHIKVIHILIQLIEKEMVK |
Gene Information
Entrez Gene ID
Gene Name
D-sedoheptulose 7-phosphate isomerase
Gene Symbol
Species
Escherichia coli K-12
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005737 | ISS:EcoCyc | C | cytoplasm |
GO:0008968 | IDA:EcoCyc | F | D-sedoheptulose 7-phosphate isomerase activity |
GO:0030246 | IEA:InterPro | F | carbohydrate binding |
GO:0008270 | IEA:UniProtKB-HAMAP | F | zinc ion binding |
GO:2001061 | IEA:UniProtKB-UniPathway | P | D-glycero-D-manno-heptose 7-phosphate biosynthetic process |
GO:0009244 | IMP:EcoCyc | P | lipopolysaccharide core region biosynthetic process |
KEGG Pathway Links
KEGG Pathway ID | Description |
---|---|
M00064 | ADP-L-glycero-D-manno-heptose biosynthesis |
eco_M00064 | ADP-L-glycero-D-manno-heptose biosynthesis |
eco00540 | Lipopolysaccharide biosynthesis |
ko00540 | Lipopolysaccharide biosynthesis |
eco01100 | Metabolic pathways |
BIOCYC Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
D-sedoheptulose 7-phosphate isomerase
Protein Entry
GMHA_ECOLI
UniProt ID
Species
E. coli
Comments
Comment Type | Description |
---|---|
Catalytic Activity | D-sedoheptulose 7-phosphate = D-glycero-D- manno-heptose 7-phosphate. {ECO:0000269|PubMed:18056714}. |
Cofactor | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250}; |
Function | Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. {ECO:0000269|PubMed:11751812, ECO:0000269|PubMed:18056714}. |
Miscellaneous | The reaction produces a racemic mixture of D- glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D- manno-heptose 7-phosphate. |
Pathway | Bacterial outer membrane biogenesis; LPS core biosynthesis. |
Pathway | Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7- phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7- phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1. |
Sequence Caution | Sequence=AAB08644.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; |
Similarity | Belongs to the SIS family. GmhA subfamily. {ECO:0000305}. |
Similarity | Contains 1 SIS domain. {ECO:0000305}. |
Subcellular Location | Cytoplasm. |
Subunit | Homotetramer. {ECO:0000269|PubMed:18056714}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP007544 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
16128208 | RefSeq | NP_414757 | 192 | D-sedoheptulose 7-phosphate isomerase [Escherichia coli str. K-12 substr. MG1655] |
Identical Sequences to LMP007544 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:16128208 | GenBank | KHJ04766.1 | 192 | phosphoheptose isomerase [Escherichia coli] |
GI:16128208 | GenBank | KHJ07921.1 | 192 | phosphoheptose isomerase [Escherichia coli] |
GI:16128208 | GenBank | KHJ17430.1 | 192 | phosphoheptose isomerase [Escherichia coli] |
GI:16128208 | GenBank | KHJ23973.1 | 192 | phosphoheptose isomerase [Escherichia coli] |
GI:16128208 | GenBank | KHJ27415.1 | 192 | phosphoheptose isomerase [Escherichia coli] |
GI:16128208 | gnl | IGS | 192 | D-sedoheptulose 7-phosphate isomerase [Escherichia coli ER2796] |
Related Sequences to LMP007544 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:16128208 | GenBank | EGI17676.1 | 246 | sedoheptulose 7-phosphate isomerase [Escherichia coli M605] |
GI:16128208 | GenBank | EGI22946.1 | 246 | sedoheptulose 7-phosphate isomerase [Escherichia coli M718] |
GI:16128208 | GenBank | EGI47742.1 | 246 | sedoheptulose 7-phosphate isomerase [Escherichia coli H591] |
GI:16128208 | GenBank | EGJ07057.1 | 246 | phosphoheptose isomerase [Escherichia coli D9] |
GI:16128208 | gnl | ChinaCDC | 246 | Phosphoheptose isomerase [Shigella flexneri 2002017] |
GI:16128208 | RefSeq | WP_000335812.1 | 246 | MULTISPECIES: phosphoheptose isomerase [Enterobacteriaceae] |