Gene/Proteome Database (LMPD)

LMPD ID
LMP007651
Gene ID
946725
Species
Escherichia coli K-12 (E. coli)
Gene Name
periplasmic glycerophosphodiester phosphodiesterase
Gene Symbol
glpQ
Synonyms
ECK2231; JW2233
Summary
None
Orthologs
View orthologs and multiple alignments for glpQ

Proteins

periplasmic glycerophosphodiester phosphodiesterase [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_416742
Protein GI 16130174
UniProt ID P09394
Length 358
RefSeq Status REVIEWED
MKLTLKNLSMAIMMSTIVMGSSAMAADSNEKIVIAHRGASGYLPEHTLPAKAMAYAQGADYLEQDLVMTKDDNLVVLHDHYLDRVTDVADRFPDRARKDGRYYAIDFTLDEIKSLKFTEGFDIENGKKVQTYPGRFPMGKSDFRVHTFEEEIEFVQGLNHSTGKNIGIYPEIKAPWFHHQEGKDIAAKTLEVLKKYGYTGKDDKVYLQCFDADELKRIKNELEPKMGMELNLVQLIAYTDWNETQQKQPDGSWVNYNYDWMFKPGAMKQVAEYADGIGPDYHMLIEETSQPGNIKLTGMVQDAQQNKLVVHPYTVRSDKLPEYTPDVNQLYDALYNKAGVNGLFTDFPDKAVKFLNKE

Gene Information

Entrez Gene ID
946725
Gene Name
periplasmic glycerophosphodiester phosphodiesterase
Gene Symbol
glpQ
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042597 IDA:EcoCyc C periplasmic space
GO:0005509 IDA:EcoCyc F calcium ion binding
GO:0008889 IDA:EcoCyc F glycerophosphodiester phosphodiesterase activity
GO:0046872 IDA:EcoCyc F metal ion binding
GO:0006071 IEA:UniProtKB-KW P glycerol metabolic process
GO:0006629 IEA:InterPro P lipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
eco00564 Glycerophospholipid metabolism
ko00564 Glycerophospholipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY0-381 glycerol and glycerophosphodiester degradation
PWY0-381 glycerol and glycerophosphodiester degradation
PWY0-381 glycerol degradation I
PWY-6952 glycerophosphodiester degradation
PWY-6952 glycerophosphodiester degradation

Domain Information

InterPro Annotations

Accession Description
IPR004129 Glycerophosphoryl diester phosphodiesterase
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

UniProt Annotations

Entry Information

Gene Name
periplasmic glycerophosphodiester phosphodiesterase
Protein Entry
GLPQ_ECOLI
UniProt ID
P09394
Species
E. coli

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=0.28 mM for glycerophosphocholine {ECO:0000269|PubMed:2829735}; KM=0.24 mM for glycerophosphoethanolamine {ECO:0000269|PubMed:2829735}; KM=0.35 mM for glycerophosphoglycerol {ECO:0000269|PubMed:2829735}; KM=0.59 mM for glycerophosphoserine {ECO:0000269|PubMed:2829735}; KM=1.0 mM for glycerophosphoinositol {ECO:0000269|PubMed:2829735}; pH dependence: Optimum pH is 7.8. {ECO:0000269|PubMed:2829735};
Catalytic Activity A glycerophosphodiester + H(2)O = an alcohol + sn-glycerol 3-phosphate. {ECO:0000269|PubMed:2829735}.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:2829735}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000269|PubMed:2829735};
Function Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols.
Miscellaneous There are 2 isozymes of glycerophosphoryl diester phosphodiesterase in E.coli: a periplasmic isozyme (GlpQ) and a cytosolic isozyme (UgpQ).
Similarity Belongs to the glycerophosphoryl diester phosphodiesterase family. {ECO:0000305}.
Similarity Contains 1 GP-PDE domain. {ECO:0000305}.
Subcellular Location Periplasm {ECO:0000269|PubMed:2829735}.
Subunit Homodimer. {ECO:0000269|PubMed:2829735, ECO:0000269|Ref.10, ECO:0000269|Ref.9}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007651 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16130174 RefSeq NP_416742 358 periplasmic glycerophosphodiester phosphodiesterase [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007651 proteins

Reference Database Accession Length Protein Name
GI:16130174 GenBank KHH49030.1 358 glycerophosphodiester phosphodiesterase [Escherichia coli]
GI:16130174 GenBank KHH89675.1 358 glycerophosphodiester phosphodiesterase [Escherichia coli]
GI:16130174 GenBank KHI15545.1 358 glycerophosphodiester phosphodiesterase [Escherichia coli]
GI:16130174 GenBank KHI19768.1 358 glycerophosphodiester phosphodiesterase [Escherichia coli]
GI:16130174 GenBank KHI59997.1 358 glycerophosphodiester phosphodiesterase [Escherichia coli]
GI:16130174 gnl IGS 358 periplasmic glycerophosphodiester phosphodiesterase [Escherichia coli ER2796]

Related Sequences to LMP007651 proteins

Reference Database Accession Length Protein Name
GI:16130174 GenBank EFK15211.1 371 glycerophosphoryl diester phosphodiesterase GlpQ [Escherichia coli MS 116-1]
GI:16130174 GenBank EFK89006.1 371 glycerophosphoryl diester phosphodiesterase GlpQ [Escherichia coli MS 146-1]
GI:16130174 GenBank EGI11887.1 371 glycerophosphoryl diester phosphodiesterase GlpQ [Escherichia coli H736]
GI:16130174 gnl zhongguo 371 Glycerophosphoryl diester phosphodiesterase [Escherichia coli P12b]
GI:16130174 RefSeq YP_006169346.1 371 glycerophosphoryl diester phosphodiesterase [Escherichia coli P12b]
GI:16130174 RefSeq WP_001310992.1 371 glycerophosphodiester phosphodiesterase [Escherichia coli]