Gene/Proteome Database (LMPD)

LMPD ID
LMP007871
Gene ID
177660
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein HYL-1
Gene Symbol
hyl-1
Synonyms
CELE_C09G4.1
Alternate Names
Protein HYL-1
Chromosome
IV
EC Number
2.3.1.24

Proteins

Protein HYL-1
Refseq ID NP_501459
Protein GI 17541106
UniProt ID G5ED45
mRNA ID NM_069058
Length 368
RefSeq Status REVIEWED
MWRMSYFWHEPYWLPRNVTWPEVPAKFVDLLVPIYLAIPLVIIRILWESTIGVTYLYFRTNAYASRKNITLLGCMWEHMTGGFASVSRAKKILECFWRFSYYTFAFLYGLYVMKNSSWLYDVKQCWIGYPFHPVPDTIWWYYMIETGFYYSLLIGSTFDVRRSDFWQLMVHHVITIFLLSSSWTINFVRVGTLILLSHDVSDVFLEGGKLVRYDAHNKNMTNFMFVLFFSSWVATRLIYYPFIVIRSAVTEAAALIQPDYILWDYQLSPPYAPRLIVFALILLFFLHIFWTFIILRIAYRTSTGGQAKDVRSDSDSDYDEEEMARRERTRLLKKKKNKVSPSTDDDDDEGEEEKNDRKARHRRAPRKE

Gene Information

Entrez Gene ID
177660
Gene Name
Protein HYL-1
Gene Symbol
hyl-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030424 IDA:WormBase C axon
GO:0005789 ISS:WormBase C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0050291 IEA:UniProtKB-EC F sphingosine N-acyltransferase activity
GO:0007568 ISS:WormBase P aging
GO:0046513 ISS:WormBase P ceramide biosynthetic process
GO:0040012 IMP:WormBase P regulation of locomotion

KEGG Pathway Links

KEGG Pathway ID Description
cel01100 Metabolic pathways
cel00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5653216 Sphingolipid de novo biosynthesis
5653217 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR016439 Longevity assurance, LAG1/LAC1
IPR006634 TRAM/LAG1/CLN8 homology domain

UniProt Annotations

Entry Information

Gene Name
Protein HYL-1
Protein Entry
HYL1_CAEEL
UniProt ID
G5ED45
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + sphingosine = CoA + N- acylsphingosine. {ECO:0000269|PubMed:19372430}.
Function Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 24 and 26 carbons. {ECO:0000269|PubMed:19372430}.
Pathway Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:19372430}.
Similarity Belongs to the sphingosine N-acyltransferase family. {ECO:0000305}.
Similarity Contains 1 TLC (TRAM/LAG1/CLN8) domain. {ECO:0000255|PROSITE-ProRule:PRU00205}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007871 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17541106 RefSeq NP_501459 368 Protein HYL-1

Identical Sequences to LMP007871 proteins

Reference Database Accession Length Protein Name
GI:17541106 EMBL CCD63994.1 368 Protein HYL-1, isoform a [Caenorhabditis elegans]
GI:17541106 GenBank AAD16893.1 368 LAG1Ce-1 [Caenorhabditis elegans]
GI:17541106 SwissProt G5ED45.1 368 RecName: Full=Ceramide synthase hyl-1 [Caenorhabditis elegans]

Related Sequences to LMP007871 proteins

Reference Database Accession Length Protein Name
GI:17541106 EMBL CDO41071.1 372 Protein HYL-1, isoform b [Caenorhabditis elegans]
GI:17541106 GenBank EFO94018.1 366 CRE-HYL-1 protein [Caenorhabditis remanei]
GI:17541106 GenBank EGT49358.1 364 hypothetical protein CAEBREN_29125 [Caenorhabditis brenneri]
GI:17541106 PIR - 362 hypothetical protein C09G4.1 - Caenorhabditis elegans [Caenorhabditis elegans]
GI:17541106 RefSeq XP_003089272.1 382 hypothetical protein CRE_23809 [Caenorhabditis remanei]
GI:17541106 RefSeq XP_003093525.1 366 CRE-HYL-1 protein [Caenorhabditis remanei]