Gene/Proteome Database (LMPD)

LMPD ID
LMP007898
Gene ID
181706
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein ACE-1
Gene Symbol
ace-1
Synonyms
CELE_W09B12.1
Chromosome
X
EC Number
3.1.1.7

Proteins

Protein ACE-1
Refseq ID NP_510660
Protein GI 17548187
UniProt ID P38433
mRNA ID NM_078259
Length 620
MRNSLLFFIFLPSTILAVDLIHLHDGSPLFGEEVLSQTGKPLTRFQGIPFAEPPVGNLRFKKPKPKQPWRIPLNATTPPNSCIQSEDTYFGDFYGSTMWNANTKLSEDCLYLNVYVPGKVDPNKKLAVMVWVYGGGFWSGTATLDVYDGRILTVEENVILVAMNYRVSIFGFLYMNRPEAPGNMGMWDQLLAMKWVHKNIDLFGGDLSRITLFGESAGAASVSIHMLSPKSAPYFHRAIIQSGSATSPWAIEPRDVALARAVILYNAMKCGNMSLINPDYDRILDCFQRADADALRENEWAPVREFGDFPWVPVVDGDFLLENAQTSLKQGNFKKTQLLAGSNRDESIYFLTYQLPDIFPVADFFTKTDFIKDRQLWIKGVKDLLPRQILKCQLTLAAVLHEYEPQDLPVTPRDWINAMDKMLGDYHFTCSVNEMALAHTKHGGDTYYYYFTHRASQQTWPEWMGVLHGYEINFIFGEPLNQKRFNYTDEERELSNRFMRYWANFAKTGDPNKNEDGSFTQDVWPKYNSVSMEYMNMTVESSYPSMKRIGHGPRRKECAFWKAYLPNLMAAVADVGDPYLVWKQQMDKWQNEYITDWQYHFEQYKRYQTYRQSDSETCGG

Gene Information

Entrez Gene ID
181706
Gene Name
Protein ACE-1
Gene Symbol
ace-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005623 IDA:WormBase C cell
GO:0030054 IEA:UniProtKB-KW C cell junction
GO:0005576 IDA:WormBase C extracellular region
GO:0016020 IDA:WormBase C membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0045202 IEA:UniProtKB-KW C synapse
GO:0003990 IDA:WormBase F acetylcholinesterase activity
GO:0004104 IBA:RefGenome F cholinesterase activity
GO:0042802 IPI:WormBase F identical protein binding
GO:0006581 IDA:WormBase P acetylcholine catabolic process
GO:0001507 ISS:WormBase P acetylcholine catabolic process in synaptic cleft
GO:0019695 IBA:RefGenome P choline metabolic process
GO:0040012 IGI:WormBase P regulation of locomotion
GO:0007271 IBA:RefGenome P synaptic transmission, cholinergic

KEGG Pathway Links

KEGG Pathway ID Description
cel00564 Glycerophospholipid metabolism
ko00564 Glycerophospholipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR014788 Acetylcholinesterase, tetramerisation domain
IPR029058 Alpha/Beta hydrolase fold
IPR019826 Carboxylesterase type B, active site
IPR019819 Carboxylesterase type B, conserved site
IPR002018 Carboxylesterase, type B
IPR000997 Cholinesterase

UniProt Annotations

Entry Information

Gene Name
Protein ACE-1
Protein Entry
ACE1_CAEEL
UniProt ID
P38433
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity Acetylcholine + H(2)O = choline + acetate.
Developmental Stage Detected at all stages. Found to be more abundant in larval stages than in embryos or adults.
Function Rapidly hydrolyzes choline released into the synapse. It can hydrolyze butyrylthiocholine.
Similarity Belongs to the type-B carboxylesterase/lipase family
Similarity Belongs to the type-B carboxylesterase/lipase family. {ECO:0000305}.
Subcellular Location Cell junction, synapse . Secreted {ECO:0000250}. Cell membrane ; Peripheral membrane protein . Note=May be secreted or membrane associated via a non-catalytic subunit.
Subcellular Location Cell junction, synapse {ECO:0000250}. Secreted {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=May be secreted or membrane associated via a non-catalytic subunit.
Subunit Oligomer composed of disulfide-linked homodimers
Subunit Oligomer composed of disulfide-linked homodimers. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007898 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17548187 RefSeq NP_510660 620 Protein ACE-1

Identical Sequences to LMP007898 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007898 proteins

Reference Database Accession Length Protein Name