Gene/Proteome Database (LMPD)

LMPD ID
LMP008158
Gene ID
175201
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein STIM-1
Gene Symbol
stim-1
Synonyms
CELE_Y55B1BM.1
Chromosome
III

Proteins

Protein STIM-1, isoform a
Refseq ID NP_741074
Protein GI 25144975
UniProt ID G5EF60
mRNA ID NM_171858
Length 530
RefSeq Status REVIEWED
MGRVSWIIALYLTINVVIVVNGDRVTRNVEVTAEEEKIRDKLGYEAIRDIHRDMDDDHSGSIDRNESTGFMKEDMQMRGSERTRRENKFHGDDDAITVDDLWEAWFESIERTWTNERLVEWLINDVNLPSIVEAVKAKKIDGKILPRFASPNSDFLNKELGIKSSVYRQKLRLNSLDVVLFGYKDNNNRTKDILLAFLALLLTSLIFLYVRQKQKAQQKVNELSNKLTELKCMETEFEDVQKMLNDERSKRSISDGVVNHTEMENLRVQLEEAERRLEANSNGSQAPLALQPLLRRTCENEMAFLEKQRQDCFKEMKEAIEMVDRLQKKQGSVLSSLKLATGAASTSDQVDSKIFALKSRMEKIHTLTRETQERWLQIESLCGFPLLYLNETEHINRSIASSHFYNKSHEGSSSSGSISNAHSNPNAVNSNFVKKVSPPIPPSQQTANLRFVPTEQSDSIHSEDTSPIVEDVAISRSLTQDLAEADMQSIVSGSTNGSGSVAALKKRKGIFPKLFRRNTSKSSSLGGTSN
Protein STIM-1, isoform b
Refseq ID NP_741073
Protein GI 25144978
UniProt ID G5EF60
mRNA ID NM_171065
Length 510
RefSeq Status REVIEWED
MGRVSWIIALYLTINVVIVVNGDRVTRNVEVTAEEEKIRDKLGYEAIRDIHRDMDDDHSGSIDRNESTGFMKEDMQMRGSERTRRENKFHGDDDAITVDDLWEAWFESIERTWTNERLVEWLINDVNLPSIVEAVKAKKIDGKILPRFASPNSDFLNKELGIKSSVYRQKLRLNSLDVVLFGYKDNNNRTKDILLAFLALLLTSLIFLYVRQKQKAQQKVNELSNKLTELKCMETEFEDVQKMLNDERSKRSISDGVVNHTEMENLRVQLEEAERRLEANSNGSQAPLALQPLLRRTCENEMAFLEKQRQDCFKEMKEAIEMVDRLQKKQGSVLSSLKLATGAASTSDQVDSKIFALKSRMEKIHTLTRETQERWLQIESLCGFPLLYLNGSSSSGSISNAHSNPNAVNSNFVKKVSPPIPPSQQTANLRFVPTEQSDSIHSEDTSPIVEDVAISRSLTQDLAEADMQSIVSGSTNGSGSVAALKKRKGIFPKLFRRNTSKSSSLGGTSN
Protein STIM-1, isoform c
Refseq ID NP_001022916
Protein GI 71995085
UniProt ID G5EF60
mRNA ID NM_001027745
Length 395
RefSeq Status REVIEWED
MGRVSWIIALYLTINVVIVVNGDRVTRNVEVTAEEEKIRDKLGYEAIRDIHRDMDDDHSGSIDRNESTGFMKEDMQMRGSERTRRENKFHGDDDAITVDDLWEAWFESIERTWTNERLVEWLINDVNLPSIVEAVKAKKIDGKILPRFASPNSDFLNKELGIKSSVYRQKLRLNSLDVVLFGYKDNNNRTKDILLAFLALLLTSLIFLYVRQKQKAQQKVNELSNKLTELKCMETEFEDVQKMLNDERSKRSISDGVVNHTEMENLRVQLEEAERRLEANSNGSQAPLALQPLLRRTCENEMAFLEKQRQDCFKEMKEAIEMVDRLQKKQGSVLSSLKLATGAASTSDQVDSKIFALKSRMEKIHTLTRETQERWLQIESLCGFPLLYLNGKFRQ

Gene Information

Entrez Gene ID
175201
Gene Name
Protein STIM-1
Gene Symbol
stim-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:WormBase C cytoplasm
GO:0030425 IDA:WormBase C dendrite
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0043229 IDA:WormBase C intracellular organelle
GO:0043025 IDA:WormBase C neuronal cell body
GO:0005886 IDA:WormBase C plasma membrane
GO:0005262 IEA:UniProtKB-KW F calcium channel activity
GO:0005246 IDA:WormBase F calcium channel regulator activity
GO:0005509 ISS:WormBase F calcium ion binding
GO:0030728 IMP:WormBase P ovulation
GO:1901076 IMP:WormBase P positive regulation of engulfment of apoptotic cell
GO:0045987 IMP:WormBase P positive regulation of smooth muscle contraction
GO:1901341 IMP:WormBase P positive regulation of store-operated calcium channel activity
GO:0000003 IMP:WormBase P reproduction
GO:0002115 IGI:WormBase P store-operated calcium entry

Domain Information

InterPro Annotations

Accession Description
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain

UniProt Annotations

Entry Information

Gene Name
Protein STIM-1
Protein Entry
G5EF60_CAEEL
UniProt ID
G5EF60
Species
C. elegans

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=a ; IsoId=G5EF60-1; Sequence=Displayed; Name=b ; IsoId=G5EF60-2; Sequence=VSP_046320; Note=No experimental confirmation available. ; Name=c ; IsoId=G5EF60-3; Sequence=VSP_046321, VSP_046322; Note=No experimental confirmation available. ;
Disruption Phenotype Sterility due to dysfunction of somatic cells. Affects the store-operated Ca(2+) (SOC) activity.
Function Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor which upon Ca(2+) depletion, activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, orai-1. Essential for Ca (2+) and IP3-dependent contractile activity of gonad sheath cells and spermatheca. Essential for fertility. Does not play a role in posterior body wall muscle contraction (pBoc) rhythmicity, intestinal cell oscillatory Ca(2+) signaling or intestinal ER Ca(2+) hemeostasis.
Similarity Contains 1 EF-hand domain.
Similarity Contains 1 SAM (sterile alpha motif) domain.
Subcellular Location Membrane {ECO:0000269|PubMed:16966474, ECO:0000269|PubMed:17218360}; Single-pass type I membrane protein . Note=Localizes to intracellular puncta in the anterior intestine and reticular structure in the posterior intestine.
Subunit Homodimer. Interacts with orai-1.
Tissue Specificity Coexpressed with orai-1 in spermatheca, gonad sheath cells and intestine. Also detected in neurons in the head and in the uterine epithelial cells. Heterogeneously expressed in the intestine with strong presence in the anterior and posterior intestine and weaker in the midsection.

Identical and Related Proteins

Unique RefSeq proteins for LMP008158 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25144975 RefSeq NP_741074 530 Protein STIM-1, isoform a
25144978 RefSeq NP_741073 510 Protein STIM-1, isoform b
71995085 RefSeq NP_001022916 395 Protein STIM-1, isoform c

Identical Sequences to LMP008158 proteins

Reference Database Accession Length Protein Name
GI:25144975 EMBL CCD73857.1 530 Protein STIM-1, isoform a [Caenorhabditis elegans]
GI:25144978 EMBL CCD73858.1 510 Protein STIM-1, isoform b [Caenorhabditis elegans]
GI:71995085 EMBL CCD73859.1 395 Protein STIM-1, isoform c [Caenorhabditis elegans]
GI:25144978 GenBank ADC23805.1 510 Sequence 74 from patent US 7645588
GI:25144975 GenBank ADS79780.1 530 Sequence 14 from patent US 7820397
GI:25144975 GenBank ADS79788.1 530 Sequence 64 from patent US 7820397
GI:25144978 GenBank ADS79789.1 510 Sequence 66 from patent US 7820397
GI:25144978 GenBank ADS79793.1 510 Sequence 74 from patent US 7820397
GI:25144975 GenBank AGA40606.1 530 Sequence 14 from patent US 8323648
GI:25144975 GenBank AGA40614.1 530 Sequence 64 from patent US 8323648
GI:25144978 GenBank AGA40615.1 510 Sequence 66 from patent US 8323648
GI:25144978 GenBank AGA40619.1 510 Sequence 74 from patent US 8323648
GI:25144975 SwissProt G5EF60.1 530 RecName: Full=Stromal interaction molecule 1; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP008158 proteins

Reference Database Accession Length Protein Name
GI:25144975 EMBL CCD73858.1 510 Protein STIM-1, isoform b [Caenorhabditis elegans]
GI:71995085 EMBL CCD73858.1 510 Protein STIM-1, isoform b [Caenorhabditis elegans]
GI:25144978 GenBank ADC23792.1 530 Sequence 14 from patent US 7645588
GI:25144978 GenBank ADC23800.1 530 Sequence 64 from patent US 7645588
GI:71995085 GenBank ADC23801.1 510 Sequence 66 from patent US 7645588
GI:25144975 GenBank ADC23801.1 510 Sequence 66 from patent US 7645588
GI:71995085 GenBank ADC23805.1 510 Sequence 74 from patent US 7645588
GI:25144975 GenBank ADC23805.1 510 Sequence 74 from patent US 7645588
GI:25144978 GenBank ADS79780.1 530 Sequence 14 from patent US 7820397
GI:25144978 GenBank ADS79788.1 530 Sequence 64 from patent US 7820397
GI:71995085 GenBank ADS79789.1 510 Sequence 66 from patent US 7820397
GI:25144975 GenBank ADS79789.1 510 Sequence 66 from patent US 7820397
GI:25144978 GenBank AGA40606.1 530 Sequence 14 from patent US 8323648
GI:25144978 GenBank AGA40614.1 530 Sequence 64 from patent US 8323648
GI:25144975 GenBank AGA40615.1 510 Sequence 66 from patent US 8323648
GI:71995085 GenBank AGA40615.1 510 Sequence 66 from patent US 8323648
GI:71995085 GenBank AGA40619.1 510 Sequence 74 from patent US 8323648
GI:25144975 GenBank AGA40619.1 510 Sequence 74 from patent US 8323648