Gene/Proteome Database (LMPD)

LMPD ID
LMP008162
Gene ID
175410
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein DAF-2
Gene Symbol
daf-2
Synonyms
CELE_Y55D5A.5
Chromosome
III

Proteins

Protein DAF-2, isoform a
Refseq ID NP_497650
Protein GI 392894369
UniProt ID Q968Y9
mRNA ID NM_065249
Length 1846
RefSeq Status REVIEWED
MTRMNIVRCRRRHKILENLEEENLGPSCSSTTSTTAATEALGTTTEDMRLKQQRSSSRATEHDIVDGNHHDDEHITMRRLRLVKNSRTRRRTTPDSSMDCYEENPPSQKTSINYSWISKKSSMTSLMLLLLFAFVQPCASIVEKRCGPIDIRNRPWDIKPQWSKLGDPNEKDLAGQRMVNCTVVEGSLTISFVLKHKTKAQEEMHRSLQPRYSQDEFITFPHLREITGTLLVFETEGLVDLRKIFPNLRVIGGRSLIQHYALIIYRNPDLEIGLDKLSVIRNGGVRIIDNRKLCYTKTIDWKHLITSSINDVVVDNAAEYAVTETGLMCPRGACEEDKGESKCHYLEEKNQEQGVERVQSCWSNTTCQKSCAYDRLLPTKEIGPGCDANGDRCHDQCVGGCERVNDATACHACKNVYHKGKCIEKCDAHLYLLLQRRCVTREQCLQLNPVLSNKTVPIKATAGLCSDKCPDGYQINPDDHRECRKCVGKCEIVCEINHVIDTFPKAQAIRLCNIIDGNLTIEIRGKQDSGMASELKDIFANIHTITGYLLVRQSSPFISLNMFRNLRRIEAKSLFRNLYAITVFENPNLKKLFDSTTDLTLDRGTVSIANNKMLCFKYIKQLMSKLNIPLDPIDQSEGTNGEKAICEDMAINVSITAVNADSVFFSWPSFNITDIDQRKFLGYELFFKEVPRIDENMTIEEDRSACVDSWQSVFKQYYETSNGEPTPDIFMDIGPRERIRPNTLYAYYVATQMVLHAGAKNGVSKIGFVRTSYYTPDPPTLALAQVDSDAIHITWEAPLQPNGDLTHYTIMWRENEVSPYEEAEKFCTDASTPANRQHTKDPKETIVADKPVDIPSSRTVAPTLLTMMGHEDQQKTCAATPGCCSCSAIEESSEQNKKKRPDPMSAIESSAFENKLLDEVLMPRDTMRVRRSIEDANRVSEELEKAENLGKAPKTLGGKKPLIHISKKKPSSSSTTSTPAPTIASMYALTRKPTTVPGTRIRLYEIYEPLPGSWAINVSALALDNSYVIRNLKHYTLYAISLSACQNMTVPGASCSISHRAGALKRTKHITDIDKVLNETIEWRFMNNSQQVNVTWDPPTEVNGGIFGYVVKLKSKVDGSIVMTRCVGAKRGYSTRNQGVLFQNLADGRYFVSVTATSVHGAGPEAESSDPIVVMTPGFFTVEIILGMLLVFLILMSIAGCIIYYYIQVRYGKKVKALSDFMQLNPEYCVDNKYNADDWELRQDDVVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYLMEANIMKNFKTNFIVKLYGVISTVQPAMVVMEMMDLGNLRDYLRSKREDEVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKPSGKRMMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHLLAAEASPEFRDLSFVLTDNQMILDDSEALDLDDIDDTDMNDQVVEVAPDVENVEVQSDSERRNTDSIPLKQFKTIPPINATTSHSTISIDETPMKAKQREGSLDEEYALMNHSGGPSDAEVRTYAGDGDYVERDVRENDVPTRRNTGASTSSYTGGGPYCLTNRGGSNERGAGFGEAVRLTDGVGSGHLNDDDYVEKEISSMDTRRSTGASSSSYGVPQTNWSGNRGATYYTSKAQQAATAAAAAAAALQQQQNGGRGDRLTQLPGTGHLQSTRGGQDGDYIETEPKNYRNNGSPSRNGNSRDIFNGRSAFGENEHLIEDNEHHPLV
Protein DAF-2, isoform b
Refseq ID NP_001122734
Protein GI 392894371
UniProt ID Q968Y9
mRNA ID NM_001129262
Length 1020
RefSeq Status REVIEWED
MTRMNIVRCRRRHKILENLEEENLGPSCSSTTSTTAATEALGTTTEDMRLKQQRSSSRATEHDIVDGNHHDDEHITMRRLRLVKNSRTRRRTTPDSSMDCYEENPPSQKTSINYSWISKKSSMTSLMLLLLFAFVQPCASIVEKRCGPIDIRNRPWDIKPQWSKLGDPNEKDLAGQRMVNCTVVEGSLTISFVLKHKTKAQEEMHRSLQPRYSQDEFITFPHLREITGTLLVFETEGLVDLRKIFPNLRVIGGRSLIQHYALIIYRNPDLEIGLDKLSVIRNGGVRIIDNRKLCYTKTIDWKHLITSSINDVVVDNAAEYAVTETGLMCPRGACEEDKGESKCHYLEEKNQEQGVERVQSCWSNTTCQKSCAYDRLLPTKEIGPGCDANGDRCHDQCVGGCERVNDATACHACKNVYHKGKCIEKCDAHLYLLLQRRCVTREQCLQLNPVLSNKTVPIKATAGLCSDKCPDGYQINPDDHRECRKCVGKCEIVCEINHVIDTFPKAQAIRLCNIIDGNLTIEIRGKQDSGMASELKDIFANIHTITGYLLVRQSSPFISLNMFRNLRRIEAKSLFRNLYAITVFENPNLKKLFDSTTDLTLDRGTVSIANNKMLCFKYIKQLMSKLNIPLDPIDQSEGTNGEKAICEDMAINVSITAVNADSVFFSWPSFNITDIDQRKFLGYELFFKEVPRIDENMTIEEDRSACVDSWQSVFKQYYETSNGEPTPDIFMDIGPRERIRPNTLYAYYVATQMVLHAGAKNGVSKIGFVRTSYYTPDPPTLALAQVDSDAIHITWEAPLQPNGDLTHYTIMWRENEVSPYEEAEKFCTDASTPANRQHTKDPKETIVADKPVDIPSSRTVAPTLLTMMGHEDQQKTCAATPGCCSCSAIEESSEQNKKKRPDPMSAIESSAFENKLLDEVLMPRCDIKNDPVGCAMLLLPPEIDDSDVGDDDEEPGGGSEQQQRILRNSEILKRQKRQILGRSLGGIHGIRSIGRKEYEQFADMILYGNLHDLMMSVMHD

Gene Information

Entrez Gene ID
175410
Gene Name
Protein DAF-2
Gene Symbol
daf-2
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:WormBase C cytoplasm
GO:0031410 IDA:WormBase C cytoplasmic vesicle
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IDA:WormBase C plasma membrane
GO:0005524 ISS:WormBase F ATP binding
GO:0042169 ISS:WormBase F SH2 domain binding
GO:0005009 ISS:WormBase F insulin-activated receptor activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0017046 ISS:WormBase F peptide hormone binding
GO:0019901 IPI:WormBase F protein kinase binding
GO:0005975 IEA:UniProtKB-KW P carbohydrate metabolic process
GO:0043054 IMP:WormBase P dauer exit
GO:0040024 IMP:WormBase P dauer larval development
GO:0008340 IMP:WormBase P determination of adult lifespan
GO:0045087 IEA:UniProtKB-KW P innate immune response
GO:0008286 ISS:WormBase P insulin receptor signaling pathway
GO:0042992 IMP:WormBase P negative regulation of transcription factor import into nucleus
GO:0040018 IMP:WormBase P positive regulation of multicellular organism growth
GO:0046777 ISS:WormBase P protein autophosphorylation
GO:2000785 IMP:BHF-UCL P regulation of autophagic vacuole assembly
GO:0040034 IGI:WormBase P regulation of development, heterochronic
GO:1901031 IMP:WormBase P regulation of response to reactive oxygen species
GO:0000003 IMP:WormBase P reproduction

Domain Information

InterPro Annotations

Accession Description
IPR000494 EGF_rcpt_L
IPR003961 Fibronectin type III
IPR006211 Furin-like_Cys-rich_dom
IPR013783 Immunoglobulin-like fold
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR000719 Protein kinase domain
IPR011009 Protein kinase-like domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR008266 Tyrosine-protein kinase, active site
IPR020635 Tyrosine-protein kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
Protein DAF-2
Protein Entry
Q968Y9_CAEEL
UniProt ID
Q968Y9
Species
C. elegans

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=a ; IsoId=Q968Y9-1; Sequence=Displayed; Name=b ; IsoId=Q968Y9-2; Sequence=VSP_053157, VSP_053158; Note=No experimental confirmation available. ;
Catalytic Activity ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000250|UniProtKB:P06213, ECO:0000255|PROSITE-ProRule:PRU10028}.
Cofactor Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ;
Disruption Phenotype Accumulation of fat, pigmented intestine, increased life span, increased dauer formation and increased resistance to pathogens. Severe loss of function mutants display recessive early embryonic lethality. {ECO:0000269|PubMed:11274053, ECO:0000269|PubMed:18245374, ECO:0000269|PubMed:18782349, ECO:0000269|PubMed:9252323, ECO:0000269|PubMed:9790527}.
Enzyme Regulation Autophosphorylation activates the kinase activity.
Function An insulin receptor-like protein which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for the response to environmental stimuli such as food, pheromone, and temperature. Role in immune function and pathogen resistance. {ECO:0000269|PubMed:11274053, ECO:0000269|PubMed:18782349, ECO:0000269|PubMed:9252323, ECO:0000269|PubMed:9790527}.
Similarity Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. {ECO:0000255|PROSITE- ProRule:PRU00159}.
Similarity Contains 1 protein kinase domain.
Similarity Contains 3 fibronectin type-III domains.
Subcellular Location Membrane ; Single-pass type I membrane protein .
Subunit Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chains carry the kinase domain (By similarity).

Identical and Related Proteins

Unique RefSeq proteins for LMP008162 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
392894369 RefSeq NP_497650 1846 Protein DAF-2, isoform a
392894371 RefSeq NP_001122734 1020 Protein DAF-2, isoform b

Identical Sequences to LMP008162 proteins

Reference Database Accession Length Protein Name
GI:392894371 EMBL CCD72203.2 1020 Protein DAF-2, isoform b [Caenorhabditis elegans]
GI:392894369 EMBL CCD72201.2 1846 Protein DAF-2, isoform a [Caenorhabditis elegans]
GI:392894369 SwissProt Q968Y9.2 1846 RecName: Full=Insulin-like receptor; Short=IR; AltName: Full=Abnormal dauer formation protein 2; Contains: RecName: Full=Insulin-like receptor subunit alpha; Contains: RecName: Full=Insulin-like receptor subunit beta; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP008162 proteins

Reference Database Accession Length Protein Name
GI:392894371 EMBL CCD72201.2 1846 Protein DAF-2, isoform a [Caenorhabditis elegans]
GI:392894369 GenBank AAC47715.1 1846 insulin receptor homolog [Caenorhabditis elegans]
GI:392894371 GenBank AAC47715.1 1846 insulin receptor homolog [Caenorhabditis elegans]
GI:392894369 GenBank AAE68917.1 1724 Sequence 12 from patent US 6225120
GI:392894369 GenBank AAY03483.1 1724 Sequence 12 from patent US 6861256
GI:392894371 GenBank AAY03483.1 1724 Sequence 12 from patent US 6861256
GI:392894369 GenBank ABH73078.1 1724 Sequence 12 from patent US 7041437
GI:392894371 GenBank ACJ92113.1 1724 Sequence 12 from patent US 7414169
GI:392894369 GenBank ACJ92113.1 1724 Sequence 12 from patent US 7414169
GI:392894369 RefSeq XP_003111771.1 1883 CRE-DAF-2 protein [Caenorhabditis remanei]
GI:392894371 RefSeq NP_497650.4 1846 Protein DAF-2, isoform a [Caenorhabditis elegans]
GI:392894371 SwissProt Q968Y9.2 1846 RecName: Full=Insulin-like receptor; Short=IR; AltName: Full=Abnormal dauer formation protein 2; Contains: RecName: Full=Insulin-like receptor subunit alpha; Contains: RecName: Full=Insulin-like receptor subunit beta; Flags: Precursor [Caenorhabditis elegans]