Gene/Proteome Database (LMPD)

LMPD ID
LMP008163
Gene ID
175502
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein TIR-1
Gene Symbol
tir-1
Synonyms
CELE_F13B10.1
Alternate Names
Protein TIR-1
Chromosome
III

Proteins

Protein TIR-1, isoform a
Refseq ID NP_497784
Protein GI 17553056
UniProt ID Q86DA5
mRNA ID NM_065383
Length 930
RefSeq Status REVIEWED
MGEEILTERNQLSRQDASCFRSPRSPLGRTDDAFFELDDDDDLSSPSVPGSPVDPPSISVPLPPKSAPPCPTQPAPLTNGDLYPTILSNGTPIPNGRITPALSTVSVSLIHEARLQQSLSTPCNGSEEEMHNGQVRKESEYRRFKSEGSTAGASLPAAEKTHMDELSPVDQRSTSGTARFLIQQDSVVNPSTKMSNTEQVAMMHTLKTKLSKYQAMMDKAFEEIAKVEDANIIEGCTIVRKLMRKVWNTPKVSADLANALCDYLRDRDYFDKLIKMFISPNTAACDQVRMECGKVLEECTSSANLEYIVNKSYTKKIMIVAMKLNKTPDQQRLSLSLIGNLFKHSNAVSLSLIETDVIDHIILTFKRAPECPDILRHAALALANILLYTCFEGKKKIIQKKIPEWLFFLASQADDVTRYYACIAVCTIVSVKEFEPLVRKSDTMKLVEPFLQVHDPATFARDYHKYAQGNTKEWLERLLPMLQPSRRREARSVAAFHFTLEATIKKEQNKLDVFQEIGAIQALKEVASSPDEVAAKFASEALTVIGEEVPYKLAQQVPGWTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLKVAADYSSVDESNLDNFLMGLSPELSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKHPDDVEVAMLSKQIDVFISYRRSTGNQLASLIKVLLQLRGYRVFIDVDKLYAGKFDSSLLKNIQAAKHFILVLTPNSLDRLLNDDNCEDWVHKELKCAFEHQKNIIPIFDTAFEFPTKEDQIPNDIRMITKYNGVKWVHDYQDACMAKVVRFITGELNRTTPTTKEMPSISRKTTQQRWQTTNTVSRTGPSRSIGGPRMEPPTPTFFSVTPTGSQERATSTRRKIQPSASTTSDRN
Protein TIR-1, isoform b
Refseq ID NP_497785
Protein GI 17553054
UniProt ID Q86DA5
mRNA ID NM_065384
Length 586
RefSeq Status REVIEWED
MCALVSSPMVSLPFNENVAPECRRNLLPRFAAVSPRPKAAVTPFVSTPSSSSITSFPYSLKLSNSNSNCSSLSRPSSLTDLPILLRDVEDQMYDDDETPIIPCGSPSSSNSMLAQIQFHPPPTEMNSPLKTSLKKLPMKTALVIRPQMFVKENSVQLERFRKSKTRRFFHPYAKEIGAIQALKEVASSPDEVAAKFASEALTVIGEEVPYKLAQQVPGWTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLKVAADYSSVDESNLDNFLMGLSPELSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKHPDDVEVAMLSKQIDVFISYRRSTGNQLASLIKVLLQLRGYRVFIDVDKLYAGKFDSSLLKNIQAAKHFILVLTPNSLDRLLNDDNCEDWVHKELKCAFEHQKNIIPIFDTAFEFPTKEDQIPNDIRMITKYNGVKWVHDYQDACMAKVVRFITGELNRTTPTTKEMPSISRKTTQQRWQTTNTVSRTGPSRSIGGPRMEPPTPTFTPTGSQERATSTRRKIQPSASTTSDRN
Protein TIR-1, isoform c
Refseq ID NP_001021251
Protein GI 71984520
UniProt ID Q86DA5
mRNA ID NM_001026080
Length 1000
RefSeq Status REVIEWED
MLPNRKPPRPSPSFQSLNNNNQRFPLRRSLKIAQAHSLPTVPSEDAKDDDLITPELSTDFDFREIQHRYLMALQNEQDGETTSTDDAFFELDDDDDLSSPSVPGSPVDPPSISVPLPPKSAPPCPTQPAPLTNGDLYPTILSNGTPIPNGRITPALSTVSVSLIHEARLQQSLSTPCNGSEEEMHNGQVRKESEYRRFKSEGSTAGASLPAAEKTHMDELSPVDQRSTSGTARFLIQQDSVVNPSTKMSNTEQVAMMHTLKTKLSKYQAMMDKAFEEIAKVEDANIIEGCTIVRKLMRKVWNTPKVSADLANALCDYLRDRDYFDKLIKMFISPNTAACDQVRMECGKVLEECTSSANLEYIVNKSYTKKIMIVAMKLNKTPDQQRLSLSLIGNLFKHSNAVSLSLIETDVIDHIILTFKRAPECPDILRHAALALANILLYTCFEGKKKIIQKKIPEWLFFLASQADDVTRYYACIAVCTIVSVKEFEPLVRKSDTMKLVEPFLQVHDPATFARDYHKYAQGNTKEWLERLLPMLQPSRRREARSVAAFHFTLEATIKKEQNKLDVFQEIGAIQALKEVASSPDEVAAKFASEALTVIGEEVPYKLAQQVPGWTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLKVAADYSSVDESNLDNFLMGLSPELSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKHPDDVEVAMLSKQIDVFISYRRSTGNQLASLIKVLLQLRGYRVFIDVDKLYAGKFDSSLLKNIQAAKHFILVLTPNSLDRLLNDDNCEDWVHKELKCAFEHQKNIIPIFDTAFEFPTKEDQIPNDIRMITKYNGVKWVHDYQDACMAKVVRFITGELNRTTPTTKEMPSISRKTTQQRWQTTNTVSRTGPSRSIGGPRMEPPTPTCKLLKHRHLVYYLIFLVFSVTPTGSQERATSTRRKIQPSASTTSDRN
Protein TIR-1, isoform d
Refseq ID NP_001021252
Protein GI 71984522
UniProt ID Q86DA5
mRNA ID NM_001026081
Length 343
RefSeq Status REVIEWED
MVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLKVAADYSSVDESNLDNFLMGLSPELSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKHPDDVEVAMLSKQIDVFISYRRSTGNQLASLIKVLLQLRGYRVFIDVDKLYAGKFDSSLLKNIQAAKHFILVLTPNSLDRLLNDDNCEDWVHKELKCAFEHQKNIIPIFDTAFEFPTKEDQIPNDIRMITKYNGVKWVHDYQDACMAKVVRFITGELNRTTPTTKEMPSISRKTTQQRWQTTNTVSRTGPSRSIGGPRMEPPTPTFTPTGSQERATSTRRKIQPSASTTSDRN
Protein TIR-1, isoform e
Refseq ID NP_001021253
Protein GI 71984529
UniProt ID Q86DA5
mRNA ID NM_001026082
Length 801
RefSeq Status REVIEWED
MHNGQVRKESEYRRFKSEGSTAGASLPAAEKTHMDELSPVDQRSTSGTARFLIQQDSVVNPSTKMSNTEQVAMMHTLKTKLSKYQAMMDKAFEEIAKVEDANIIEGCTIVRKLMRKVWNTPKVSADLANALCDYLRDRDYFDKLIKMFISPNTAACDQVRMECGKVLEECTSSANLEYIVNKSYTKKIMIVAMKLNKTPDQQRLSLSLIGNLFKHSNAVSLSLIETDVIDHIILTFKRAPECPDILRHAALALANILLYTCFEGKKKIIQKKIPEWLFFLASQADDVTRYYACIAVCTIVSVKEFEPLVRKSDTMKLVEPFLQVHDPATFARDYHKYAQGNTKEWLERLLPMLQPSRRREARSVAAFHFTLEATIKKEQNKLDVFQEIGAIQALKEVASSPDEVAAKFASEALTVIGEEVPYKLAQQVPGWTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLKVAADYSSVDESNLDNFLMGLSPELSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKHPDDVEVAMLSKQIDVFISYRRSTGNQLASLIKVLLQLRGYRVFIDVDKLYAGKFDSSLLKNIQAAKHFILVLTPNSLDRLLNDDNCEDWVHKELKCAFEHQKNIIPIFDTAFEFPTKEDQIPNDIRMITKYNGVKWVHDYQDACMAKVVRFITGELNRTTPTTKEMPSISRKTTQQRWQTTNTVSRTGPSRSIGGPRMEPPTPTFFSVTPTGSQERATSTRRKIQPSASTTSDRN

Gene Information

Entrez Gene ID
175502
Gene Name
Protein TIR-1
Gene Symbol
tir-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030424 IDA:WormBase C axon
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0017137 IPI:WormBase F Rab GTPase binding
GO:0042802 IPI:IntAct F identical protein binding
GO:0019901 IPI:WormBase F protein kinase binding
GO:0000187 IMP:WormBase P activation of MAPK activity
GO:0045168 IMP:WormBase P cell-cell signaling involved in cell fate commitment
GO:0042742 IMP:WormBase P defense response to bacterium
GO:0050832 IMP:WormBase P defense response to fungus
GO:0045087 IEA:UniProtKB-KW P innate immune response
GO:0007399 IEA:UniProtKB-KW P nervous system development
GO:0045944 IMP:WormBase P positive regulation of transcription from RNA polymerase II promoter
GO:1902097 IMP:WormBase P positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium
GO:0008104 IMP:WormBase P protein localization
GO:0007165 IEA:InterPro P signal transduction

Domain Information

InterPro Annotations

Accession Description
IPR011989 Armadillo-like helical
IPR016024 Armadillo-type fold
IPR001660 Sterile alpha motif domain
IPR021129 Sterile alpha motif, type 1
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR000157 Toll/interleukin-1 receptor homology (TIR) domain

UniProt Annotations

Entry Information

Gene Name
Protein TIR-1
Protein Entry
SARM1_CAEEL
UniProt ID
Q86DA5
Species
C. elegans

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=5; Name=c; IsoId=Q86DA5-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=a; IsoId=Q86DA5-2; Sequence=VSP_013608, VSP_013612; Note=No experimental confirmation available.; Name=b; IsoId=Q86DA5-3; Sequence=VSP_013609, VSP_013610, VSP_013614; Note=No experimental confirmation available.; Name=d; IsoId=Q86DA5-4; Sequence=VSP_013613, VSP_013614; Note=No experimental confirmation available.; Name=e; IsoId=Q86DA5-5; Sequence=VSP_013611, VSP_013612; Note=No experimental confirmation available.;
Domain The SAM domains mediate the localization to postsynaptic regions of neurons. {ECO:0000269|PubMed:15625192}.
Domain The TIR domain is required to activate signaling cascade, possibly for activation of nsy-1. {ECO:0000269|PubMed:15625192}.
Function Required for both innate immune response and specification of AWC(OFF) neuron. During late embryogenesis, it acts downstream of CAMKII (unc-43) to regulate specification of asymmetric odorant receptors in AWC(OFF) neuron via the nsy-1/ASK1 pmk-1/p38 MAP kinase signaling cascade. Required to localize nsy-1 to postsynaptic regions of AWC neuron, suggesting that it may act by assembling a signaling complex that regulate odorant receptor expression. Also plays a central role in resistance to infection to a broad range of bacterial and fungi pathogens, possibly by activating pmk-1, independently of the NF-kappa-B pathway. Required for expression of antimicrobial peptides nlp-29 and nlp- 31. Its role in immune response and neuron specification may be mediated by the same nsy-1/ASK1 pmk-1/p38 MAP kinase cascade signaling pathway. {ECO:0000269|PubMed:15048112, ECO:0000269|PubMed:15123841, ECO:0000269|PubMed:15625192}.
Interaction Self; NbExp=3; IntAct=EBI-319472, EBI-319472;
Similarity Contains 1 TIR domain. {ECO:0000255|PROSITE- ProRule:PRU00204}.
Similarity Contains 2 SAM (sterile alpha motif) domains. {ECO:0000255|PROSITE-ProRule:PRU00184}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15625192}.
Subunit Homodimer (Probable). Interacts with rab-1, pal-1 and unc-43. {ECO:0000269|PubMed:15048112, ECO:0000269|PubMed:15625192, ECO:0000305}.
Tissue Specificity Highly expressed in hypodermis. Localizes to postsynaptic regions of axons. {ECO:0000269|PubMed:15048112, ECO:0000269|PubMed:15625192}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008163 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17553056 RefSeq NP_497784 930 Protein TIR-1, isoform a
17553054 RefSeq NP_497785 586 Protein TIR-1, isoform b
71984520 RefSeq NP_001021251 1000 Protein TIR-1, isoform c
71984522 RefSeq NP_001021252 343 Protein TIR-1, isoform d
71984529 RefSeq NP_001021253 801 Protein TIR-1, isoform e

Identical Sequences to LMP008163 proteins

Reference Database Accession Length Protein Name
GI:17553054 EMBL CAA90181.1 586 Protein TIR-1, isoform b [Caenorhabditis elegans]
GI:17553056 EMBL CAA90182.1 930 Protein TIR-1, isoform a [Caenorhabditis elegans]
GI:71984520 EMBL CAD90174.1 1000 Protein TIR-1, isoform c [Caenorhabditis elegans]
GI:71984522 EMBL CAE47466.1 343 Protein TIR-1, isoform d [Caenorhabditis elegans]
GI:71984529 EMBL CAE47467.1 801 Protein TIR-1, isoform e [Caenorhabditis elegans]
GI:71984520 SwissProt Q86DA5.1 1000 RecName: Full=Sterile alpha and TIR motif-containing protein tir-1; AltName: Full=Neuronal symmetry protein 2; AltName: Full=SARM1 homolog [Caenorhabditis elegans]

Related Sequences to LMP008163 proteins

Reference Database Accession Length Protein Name
GI:71984522 EMBL CAA90181.1 586 Protein TIR-1, isoform b [Caenorhabditis elegans]
GI:71984522 EMBL CAA90182.1 930 Protein TIR-1, isoform a [Caenorhabditis elegans]
GI:71984529 EMBL CAA90182.1 930 Protein TIR-1, isoform a [Caenorhabditis elegans]
GI:17553054 EMBL CAA90182.1 930 Protein TIR-1, isoform a [Caenorhabditis elegans]
GI:71984520 EMBL CAA90182.1 930 Protein TIR-1, isoform a [Caenorhabditis elegans]
GI:17553056 EMBL CAD90174.1 1000 Protein TIR-1, isoform c [Caenorhabditis elegans]
GI:71984522 EMBL CAE47467.1 801 Protein TIR-1, isoform e [Caenorhabditis elegans]
GI:71984520 EMBL CAE47467.1 801 Protein TIR-1, isoform e [Caenorhabditis elegans]
GI:17553054 EMBL CAP24472.1 585 Protein CBR-TIR-1 [Caenorhabditis briggsae]
GI:71984520 GenBank AAV91312.1 931 Toll and interleukin 1 receptor domain protein isoform a [Caenorhabditis elegans]
GI:71984529 GenBank AAV91312.1 931 Toll and interleukin 1 receptor domain protein isoform a [Caenorhabditis elegans]
GI:17553056 GenBank AAV91312.1 931 Toll and interleukin 1 receptor domain protein isoform a [Caenorhabditis elegans]
GI:71984529 GenBank AAV91313.1 984 Toll and interleukin 1 receptor domain protein isoform c [Caenorhabditis elegans]
GI:71984520 GenBank AAV91313.1 984 Toll and interleukin 1 receptor domain protein isoform c [Caenorhabditis elegans]
GI:17553056 GenBank AAV91313.1 984 Toll and interleukin 1 receptor domain protein isoform c [Caenorhabditis elegans]
GI:17553054 GenBank AAV91314.1 589 Toll and interleukin 1 receptor domain protein isoform f [Caenorhabditis elegans]
GI:71984522 RefSeq NP_497785.1 586 Protein TIR-1, isoform b [Caenorhabditis elegans]
GI:17553054 RefSeq NP_497784.1 930 Protein TIR-1, isoform a [Caenorhabditis elegans]
GI:71984520 RefSeq NP_497784.1 930 Protein TIR-1, isoform a [Caenorhabditis elegans]
GI:71984522 RefSeq NP_497784.1 930 Protein TIR-1, isoform a [Caenorhabditis elegans]
GI:71984529 RefSeq NP_497784.1 930 Protein TIR-1, isoform a [Caenorhabditis elegans]
GI:71984529 RefSeq NP_001021251.1 1000 Protein TIR-1, isoform c [Caenorhabditis elegans]
GI:17553056 RefSeq NP_001021251.1 1000 Protein TIR-1, isoform c [Caenorhabditis elegans]
GI:71984520 RefSeq NP_001021253.1 801 Protein TIR-1, isoform e [Caenorhabditis elegans]
GI:17553056 RefSeq NP_001021253.1 801 Protein TIR-1, isoform e [Caenorhabditis elegans]
GI:17553054 RefSeq NP_001021253.1 801 Protein TIR-1, isoform e [Caenorhabditis elegans]
GI:71984522 RefSeq NP_001021253.1 801 Protein TIR-1, isoform e [Caenorhabditis elegans]
GI:17553054 RefSeq XP_002647081.1 585 C. briggsae CBR-TIR-1 protein [Caenorhabditis briggsae]
GI:17553056 SwissProt Q86DA5.1 1000 RecName: Full=Sterile alpha and TIR motif-containing protein tir-1; AltName: Full=Neuronal symmetry protein 2; AltName: Full=SARM1 homolog [Caenorhabditis elegans]
GI:71984529 SwissProt Q86DA5.1 1000 RecName: Full=Sterile alpha and TIR motif-containing protein tir-1; AltName: Full=Neuronal symmetry protein 2; AltName: Full=SARM1 homolog [Caenorhabditis elegans]