Gene/Proteome Database (LMPD)

LMPD ID
LMP008211
Gene ID
176882
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein EFN-4
Gene Symbol
efn-4
Synonyms
CELE_F56A11.3
Alternate Names
Protein EFN-4
Chromosome
IV

Proteins

Protein EFN-4
Refseq ID NP_499947
Protein GI 17539606
UniProt ID O44516
mRNA ID NM_067546
Length 348
RefSeq Status REVIEWED
MKQFFEFLITTFLLLGLAAADEHIVYWNSTNSLFRNRQPTIEVRMGDVVRFVCPDNEEGRNDGEYLIVYEVTEFAMDDCALESHSREVIRCAPEGTAEKVLRTQQLSGGRREDWKKQKVPPKNVAQLIRQLNPIPNGKEYQPGQTYYYMTTSTGKANGTNHRMYGLCESQNMRLSMKVSASQPHPTRRAPTRRQEDFVTTASAELMGGQEDEDSDNDNAHLLPRDLEGSTNPKFRRPSQLETAGVENQQFMKVVQMAQAGKTGTFENEKEAIAQKSSEKDGWHPVNVQYVADLMNNAYQNADERISYQRDFEIHEENDLAVKSLEYSSSSTSLSTNFAILLAVIYVLY

Gene Information

Entrez Gene ID
176882
Gene Name
Protein EFN-4
Gene Symbol
efn-4
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031225 IEA:UniProtKB-KW C anchored component of membrane
GO:0030424 IDA:WormBase C axon
GO:0043025 IDA:WormBase C neuronal cell body
GO:0005886 IBA:RefGenome C plasma membrane
GO:0046875 IBA:RefGenome F ephrin receptor binding
GO:0007411 IBA:RefGenome P axon guidance
GO:0042074 IMP:WormBase P cell migration involved in gastrulation
GO:0009792 IMP:WormBase P embryo development ending in birth or egg hatching
GO:0048013 IBA:RefGenome P ephrin receptor signaling pathway
GO:0016331 IMP:WormBase P morphogenesis of embryonic epithelium
GO:0045138 IMP:WormBase P nematode male tail tip morphogenesis
GO:0030155 IMP:WormBase P regulation of cell adhesion

Domain Information

InterPro Annotations

Accession Description
IPR008972 Cupredoxin
IPR001799 Ephrin

UniProt Annotations

Entry Information

Gene Name
Protein EFN-4
Protein Entry
EFN4_CAEEL
UniProt ID
O44516
Species
C. elegans

Comments

Comment Type Description
Developmental Stage Expressed in the developing nervous system. {ECO:0000269|PubMed:12403719}.
Disruption Phenotype Worms have widespread defects in embryonic morphogenesis of the posterior body and defects in postembryonic male tail morphogenesis. {ECO:0000269|PubMed:12403719}.
Function Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, involved in ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting together with mab-20 and allows the formation of distinct sensory rays. {ECO:0000269|PubMed:12403719, ECO:0000269|PubMed:12679110, ECO:0000269|PubMed:15030761}.
Miscellaneous In contrast to other ephrins, does not seem to signal through the vab-1 receptor.
Similarity Belongs to the ephrin family. {ECO:0000255|PROSITE- ProRule:PRU00884}.
Similarity Contains 1 ephrin RBD (ephrin receptor-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU00884}.
Subcellular Location Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008211 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17539606 RefSeq NP_499947 348 Protein EFN-4

Identical Sequences to LMP008211 proteins

Reference Database Accession Length Protein Name
GI:17539606 EMBL CCD65257.1 348 Protein EFN-4 [Caenorhabditis elegans]
GI:17539606 GenBank AAL05561.1 348 ephrin EFN-4 [Caenorhabditis elegans]
GI:17539606 SwissProt O44516.2 348 RecName: Full=Ephrin-4; AltName: Full=Protein male abnormal 26; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP008211 proteins

Reference Database Accession Length Protein Name
GI:17539606 EMBL CAP22999.1 354 Protein CBR-EFN-4 [Caenorhabditis briggsae]
GI:17539606 GenBank EFO92960.1 356 CRE-EFN-4 protein [Caenorhabditis remanei]
GI:17539606 GenBank EGT51471.1 322 hypothetical protein CAEBREN_08149 [Caenorhabditis brenneri]
GI:17539606 RefSeq XP_002634068.1 354 C. briggsae CBR-EFN-4 protein [Caenorhabditis briggsae]
GI:17539606 RefSeq XP_003108160.1 356 CRE-EFN-4 protein [Caenorhabditis remanei]
GI:17539606 SwissProt Q624D2.1 354 RecName: Full=Ephrin-4; Flags: Precursor [Caenorhabditis briggsae]